Methotrexate in acute persistent humoral rejection: An option for graft rescue

Annals of Thoracic Surgery

Volumn 76, Issue 2, 2003, Pages 607-610

  Bacal, Fernando ^a,b   Sodré, Gustavo L ^a   Fernandes, Daniela A ^a   Aiello, Vera D ^a   Stolf, Noedir ^a   Bocchi, Edimar ^a   Bellotti, Giovanni ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b NONE   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMETABOLITE; AZATHIOPRINE; CORTICOSTEROID; CYCLOPHOSPHAMIDE; CYCLOSPORIN; DIHYDROFOLATE REDUCTASE INHIBITOR; IMMUNOGLOBULIN; METHOTREXATE; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; OKT 3; TACROLIMUS; THYMOCYTE ANTIBODY;

ADULT; ARTICLE; CASE REPORT; ECHOCARDIOGRAPHY; FEMALE; GRAFT REJECTION; HEART MUSCLE BIOPSY; HUMAN; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOREGULATION; MALE; PLASMAPHERESIS; PRIORITY JOURNAL; RECURRENT DISEASE;

ACUTE DISEASE; ADULT; ANTIBODY FORMATION; CARDIOMYOPATHY, DILATED; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; HUMANS; MALE; METHOTREXATE; PROGNOSIS; TRANSPLANTATION IMMUNOLOGY; TREATMENT OUTCOME;

EID: 0042158223     PISSN: 00034975     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-4975(03)00143-7     Document Type: Article

References (6)

1. Costanzo-Nordin MR, Heroux AL, Radvany R, et al. Role of humoral immunity in acute cardiac allograft dysfunction. J Heart Lung Transplant 1993;12:S143-6.
2. Grauhan O, Müller J, v Baeyer H, et al. Treatment of humoral rejection after heart transplantation. J Heart Lung Transplant 1998;17:1184-94.
3. Hosenpud JD, Hershberger RA, Ratkovec RR, et al. Methotrexate for the treatment of patients with multiple episodes of acute cardiac allograft rejection. J Heart Lung Transplant 1992;11:739-45.
4. Costanzo-Nordin MR, Grusk BB, Silver MA, et al. Reversal of recalcitrant cardiac allograft rejection with methotrexate. Circulation 1998;78(Suppl III):III-47-57.
5. Rosenthal GJ, Weigand GW, Germolec DR. Suppression of B cell function by methotrexate and trimetrexate: evidence of inhibition of purine biosynthesis as a major mechanism of action. J Immunol 1988;141:410-6.
6. Bacal F, Veiga VC, Fiorelli AE, et al. Treatment of persistent rejection with methotrexate in stable patients undergoing heart transplantation. Arq Bras Cardiol 2000;74:141-4.