Diastereoselective heterogeneous catalytic hydrogenation of 2-methyl nicotinic acid using pyroglutamate chiral auxiliary

Tetrahedron Letters

Volumn 44, Issue 37, 2003, Pages 6991-6993

  Douja, Najiba ^a   Malacea, Raluca ^a,b   Banciu, Mircea ^b   Besson, Michèle ^a   Pinel, Catherine ^a  

^a INST DE RECHERCHES SUR LA CATALYSE   (France)

^b UNIVERSITY POLITEHNICA OF BUCHAREST   (Romania)

Author keywords

Diastereoselective; Heterogeneous asymmetric catalysis; Optically active piperidine; Pyridine

Indexed keywords

NICOTINIC ACID; PROLINE DERIVATIVE; PYRIDINIUM DERIVATIVE; PYROGLUTAMIC ACID;

ARTICLE; CATALYSIS; CATALYST; CHEMICAL ANALYSIS; CHIRALITY; COVALENT BOND; HYDROGENATION; STEREOCHEMISTRY;

EID: 0042158221     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(03)01794-5     Document Type: Article

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13. Typical hydrogenation reaction: Hydrogenation of the substrates was carried out in a stainless steel autoclave equipped with a magnetically driven turbine stirrer under 50 bar and at room temperature. Standard experiments used 2.25 mmol of substrate dissolved in 130 ml ethanol in the presence of 10-12 mol% of metal as the catalyst. Sampling of the mixture, to follow reaction progress, was possible and the conversion and selectivity were determined from Gas Chromatography analyses (GC) which were performed using a Shimadzu GC14A apparatus with a J&W DB1701 column.
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