A new suppressive agent against interleukin-1β and tumor necrosis factor-α enhances liver regeneration after partial hepatectomy in rats

Hepatology Research

Volumn 26, Issue 1, 2003, Pages 40-46

  Hou, Zhengsheng ^a   Yanaga, Katsuhiko ^a   Kamohara, Yukio ^a   Eguchi, Susumu ^a   Tsutsumi, Ryuji ^a   Furui, Junichiro ^a   Kanematsu, Takashi ^a  

^a NAGASAKI UNIVERSITY   (Japan)

Author keywords

FR167653; Ischemia reperfusion injury; Liver injury

Indexed keywords

1 [7 (4 FLUOROPHENYL) 1,2,3,4 TETRAHYDRO 8 (4 PYRIDYL)PYRAZOLO[5,1 C][1,2,4]TRIAZIN 2 YL] 2 PHENYLETHANEDIONE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CELL NUCLEUS ANTIGEN; CYTOKINE; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; DNA SYNTHESIS; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; GENE EXPRESSION REGULATION; LABELING INDEX; LIVER INJURY; LIVER REGENERATION; LIVER WEIGHT; MALE; MITOSIS INDEX; NONHUMAN; PARTIAL HEPATECTOMY; PRIORITY JOURNAL; RAT; STATISTICAL ANALYSIS;

EID: 0042092012     PISSN: 13866346     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1386-6346(02)00334-0     Document Type: Article

References (30)

1. Fausto N, Webber EM. Liver regeneration. In: Arias I, Boyer J, Fausto N, Jakoby W, Schacheter D, Shafritz D, editors. The liver biology and pathobiology. New York: Raven Press, 1994:1059-84.
2. Akerman P, Cote P, Yang SQ, et al. Antibodies to tumor necrosis factor-alpha inhibit liver regeneration after partial hepatectomy. Am J Physiol 1992;263:G579-85.
3. Yamada Y, Kirillova I, Peschon JJ, Fausto N. Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor. Proc Natl Acad Sci USA 1997;94:1441-6.
4. Cressman DE, Greenbaum LE, DeAngelis RA, et al. Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice. Science 1996;274:1379-83.
5. Lindroos PM, Zarnegar R, Michalopoulos GK. Hepatocyte growth factor (hepatopoietin A) rapidly increases in plasma before DNA synthesis and liver regeneration stimulated by partial hepatectomy and carbon tetrachloride administration. Hepatology 1991;13:743-50.
6. Russell WE, Dempsey PJ, Sitaric S, Peck AJ, Coffey RJ. Transforming growth factor-alpha (TGF alpha) concentrations increase in regenerating rat liver: evidence for a delayed accumulation of mature TGF alpha. Endocrinology 1993;133:1731-8.
7. Boermeester MA, Straatsburg IH, Houdijk AP, et al. Endotoxin and interleukin-1 related hepatic inflammatory response promotes liver failure after partial hepatectomy. Hepatology 1995;22:1499-506.
8. Braun L, Mead JE, Panzica M, Mikumo R, Bell GI, Fausto N. Transforming growth factor beta mRNA increases during liver regeneration: a possible paracrine mechanism of growth regulation. Proc Natl Acad Sci USA 1988;85:1539-43.
9. Yasuda H, Mine T, Shibata H, et al. Activin A: an autocrine inhibitor of initiation of DNA synthesis in rat hepatocytes. J Clin Invest 1993;92:1491-6.
10. Yamamoto N, Sakai F, Yamazaki H, Nakahara K, Okuhara M. Effect of FR167653, a cytokine suppressive agent, on endotoxin-induced disseminated intravascular coagulation. Eur J Pharmacol 1996;314:137-42.
11. Yamamoto N, Sakai F, Yamazaki H, Sato N, Nakahara K, Okuhara M. FR167653, a dual inhibitor of interleukin-1 and tumor necrosis factor-alpha, ameliorates endotoxin-induced shock. Eur J Pharmacol 1997;327:169-74.
12. Kobayashi M, Takeyoshi I, Yoshinari D, Matsumoto K, Morishita Y. P38 mitogen-activated protein kinase inhibition attenuates ischemia-reperfusion injury of the rat liver. Surgery 2002;131:344-9.
13. Higgins GM, Anderson RM. Experimental pathology of the liver. Restoration of the liver of the white rat following partial surgical removal. Arch Pathol 1931;12:186-202.
14. Higashitsuji H, Arii S, Furutani M, et al. Expression of cytokine genes during liver regeneration after partial hepatectomy in rats. J Surg Res 1995;58:267-74.
15. Eguchi S, Kamlot A, Ljubimova J, et al. Fulminant hepatic failure in rats: survival and effect on blood chemistry and liver regeneration. Hepatology 1996;24:1452-9.
16. Meijer C, Wiezer MJ, Diehl AM, et al. Kupffer cell depletion by CI2MDP-liposomes alters hepatic cytokine expression and delays liver regeneration after partial hepatectomy. Liver 2000;20:66-77.
17. Straatsburg IH, Boermeester MA, Houdijk AP, et al. Endotoxin-and cytokine-mediated effects on liver cell proliferation and lipid metabolism after partial hepatectomy: a study with recombinant N-terminal bactericidal/permeability-increasing protein and interleukin-1 receptor antagonist. J Pathol 1996;179:100-5.
18. Rai RM, Loffreda S, Karp CL, Yang SQ, Lin HZ, Diehl AM. Kupffer cell depletion abolishes induction of interleukin-10 and permits sustained overexpression of tumor necrosis factor alpha messenger RNA in the regenerating rat liver. Hepatology 1997;25:889-95.
19. Feingold KR, Soued M, Grunfeld C. Tumor necrosis factor stimulates DNA synthesis in the liver of intact rats. Biochem Biophys Res Commun 1988;153:576-82.
20. Beyer HS, Stanley M. Tumor necrosis factor-alpha increases hepatic DNA and RNA and hepatocyte mitosis. Biochem Int 1990;22:405-10.
21. Nakamura T, Arakaki R, Ichihara A. Interleukin-1 beta is a potent growth inhibitor of adult rat hepatocytes in primary culture. Exp Cell Res 1988;179:488-97.
22. Boulton R, Woodman A, Calnan D, Selden C, Tam F, Hodgson H. Nonparenchymal cells from regenerating rat liver generate interleukin-1 alpha and -1 beta: a mechanism of negative regulation of hepatocyte proliferation. Hepatology 1997;26:49-58.
23. Geller DA, De Vera ME, Russell DA, et al. A central role for IL-1 beta in the in vitro and in vivo regulation of hepatic inducible nitric oxide synthase. IL-1 beta induces hepatic nitric oxide synthesis. J Immunol 1995;155:4890-8.
24. Kitade H, Sakitani K, Inoue K, et al. Interleukin 1 beta markedly stimulates nitric oxide formation in the absence of other cytokines or lipopolysaccharide in primary cultured rat hepatocytes but not in Kupffer cells. Hepatology 1996;23:797-802.
25. Wang Z, Wang M, Carr BI. The inhibitory effect of interleukin 1 beta on rat hepatocyte DNA synthesis is mediated by nitric oxide. Hepatology 1998;28:430-5.
26. Tu W, Kitade H, Kaibori M, et al. An enhancement of nitric oxide production regulates energy metabolism in rat hepatocytes after a partial hepatectomy. J Hepatol 1999;30:944-50.
27. Otani Y, Takeyoshi I, Koibuchi Y, et al. FR167653 ameliorates pulmonary ischemia-reperfusion injury. Transplant Proc 1999;31:1010-1.
28. Phan SH, Gharaee-Kermani M, McGarry B, Kunkel SL, Wolber FW. Regulation of rat pulmonary artery endothelial cell transforming growth factor-beta production by IL-1 beta and tumor necrosis factor-alpha. J Immunol 1992;149:103-6.
29. Offner FA, Feichtinger H, Stadlmann S, et al. Transforming growth factor-beta synthesis by human peritoneal mesothelial cells. Induction by interleukin-1. Am J Pathol 1996;148:1679-88.
30. Tominaga K, Arakawa T, Watanabe T, et al. Increased mRNA levels of transforming growth factor-beta1 and monocyte chemoattractant protein-1 in ulcer relapse caused by interleukin-1 beta in rats. Dig Dis Sci 1998;43:134S-8S.