Factors affecting aerosol performance during nebulization with jet and ultrasonic nebulizers

European Journal of Pharmaceutical Sciences

Volumn 19, Issue 5, 2003, Pages 443-455

  Steckel, Hartwig ^a   Eskandar, Fadi ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

Droplet size; Jet nebulizer; Nebulization time; Saturated vapour pressure; Ultrasonic nebulizer

Indexed keywords

AEROSOLS; DROP FORMATION; JETS; SOLUTIONS; SURFACE TENSION; TEMPERATURE; ULTRASONICS; VAPOR PRESSURE; VISCOSITY OF LIQUIDS;

NEBULIZATION;

DRUG THERAPY;

AVISCUMINE; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; DRUG FORMULATION; FREEZE DRYING; NEBULIZATION; NEBULIZER; PARTICLE SIZE; PRIORITY JOURNAL; SURFACE TENSION; TEMPERATURE SENSITIVITY; VAPOR PRESSURE; VISCOSITY;

EID: 0042090595     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(03)00148-9     Document Type: Article

References (22)

1. Atkins, P.J., Barker, N.P., Mathisen, D., 1992. The design and development of inhalation drug delivery systems. In: Hickey, A.J. (Eds.), Pharmaceutical inhalation aerosol technology, Vol. 54, Marcel Dekker, New York, 155-185.
2. Callaghan C.O., Barry P.W. The Science of nebulized drug delivery. Thorax. 52:1997;31-44.
3. Dalby R., Tiano S., Hickey A. Medical devices for the delivery of therapeutic aerosols to the lungs. Hickey A. Inhalation Aerosols. Vol. 94:1997;Dekker, New York.
4. Dennis J.H., Stenton S.C., Beach J.R., Avery A.J., Zalters E.H., Hendrick D.J. Jet and ultrasonic nebulizer output: use of a new method for direct measurement of aerosol output. Thorax. 54:1990;728-732.
5. Ding J.Y., Brooker M.J., Andre M.J., Andre J.C., Zimlich W.C., Imondi A.R., Placke M.E. Performance evaluation of the Pari LC nebulizer using different nebulization pressures. Respiratory Drug Delivery. VII:2000;349-351.
6. Eskandar, F., 2002. Stabilisierung von rViscumin für die pulmonale Applikation. Diploma Thesis, Christian-Albrecht-University, Kiel, Germany.
7. European Pharmacopoeia. 1997;19-20 Allgemeine Methoden.
8. Ferron G.A., Kerrebun K.F., Weber J. Properties of aerosols produced with three nebulizers. Am. Rev. Respir. Dis. 114:1976;899-908.
9. Finlay W.H. Particle size changes due to evaporation or condensation. Finlay W.H. The Mechanics of Inhaled Pharmaceutical Aerosols. 2001;47-91 Academic Press, London.
10. Finlay W.H. Jet nebulizers. Finlay W.H. The Mechanics of Inhaled Pharmaceutical Aerosols. 2001;175-220b Academic Press, London.
11. Gloger, O., 2002. Stabilisierung von rekombinantem Mistellektin durch Gefriertrocknung. PhD Thesis, Christian-Albrecht-University, Kiel, Germany.
12. Greenspan B.J. Ultrasonic and electro hydrodynamic methods for aerosol generation. Hickey A.J. Inhalation Aerosol. Vol. 94:1996;313-335 Marcel Dekker, New York.
13. Grignon N., Touraine B., Durand M. 6(5) Carboxyfluoresceine as a tracer of phloem sap translocation. Amer. J. Bot. 76:1989;871-877.
14. Ip A.Y., Niven R.W. Prediction and experimental determination of solute output from a collision nebulizer. J. Pharm. Sci. 83:1994;1047-1051.
15. Le Brun H., de Boer A.H., Herijerman H.G., Frijlink H.W. A review of the technical aspects of drug nebulization. Pharm. World & Science. 22:2000;75-81.
16. McCallion O.N., Taylor K.M., Thomas M., Taylor A. Nebulization of fluids of different physicochemical properties with air-jet and ultrasonic nebulizers. Pharm. Res. 12:1995;1682-1688.
17. Mercer T.T., Tilley M.I., Clow H.Y. Operating characteristics of some compressed air nebulizers. Am. Ind. Hyg. Assoc. J. 29:1968;66-78.
18. Newman S.P., Goodman G., Clarke S.W. Deposition of carbenicillin aerosols in cystic fibrosis effect of nebulizer system and breathing pattern. Thorax. 43:1988;318-322.
19. Newman S.P., Pellow P.G., Clarke S.W. Droplet sizes from medical atomizers for drug solutions with different viscosity and surface tension. Atomization Spray Tech. 3:1987;1-11.
20. Niven R.W. Atomization and nebulizers. Hickey A.J. Inhalation Aerosols. Vol. 94:1996;273-312 Marcel Dekker, New York.
21. Niven R.W., Ip A.Y., Mittelman S., Prestreliski S.J., Arakawa T. Some factors associated with the ultrasonic nebulization of proteins. Pharm. Res. 12:1995;53-59.
22. Phipps P.R., Gonda I. Droplets produced by medical nebulizers: some factors affecting their size and solute concentration. Chest. 97:1990;1327-1332.