Absence of somatic mutations within the runt domain of AML2/RUNX3 in acute myeloid leukaemia [6]

Leukemia

Volumn 17, Issue 8, 2003, Pages 1677-1678

  Otto, F ^a   Stock, M ^a,b   Fliegauf, M ^a,b   Fenaux, P ^c   Preudhomme, C ^d   Lubbert M ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c UNIVERSITÉ PARIS 13   (France)

^d Institut de Recherche sur le Cancer de Lille   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AML; TRANSCRIPTION FACTOR RUNX3; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; CHROMOSOME 21; CHROMOSOME TRANSLOCATION; GENE AMPLIFICATION; GENE EXPRESSION; GENE IDENTIFICATION; GENE SEQUENCE; GENETIC CODE; GENETIC PREDISPOSITION; HEMATOPOIETIC CELL; HUMAN; LETTER; LEUKEMOGENESIS; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SOMATIC MUTATION;

EID: 0042026820     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2403007     Document Type: Letter

References (8)

1. Imai Y, Kurokawa M, Izutsu K, Hangaishi A, Takeuchi K, Maki K et al. Mutations of the AML1 gene in myelodysplastic syndrome and their functional implications in leukemogenesis. Blood 2000; 96: 3154-3160.
2. Osato M, Asou N, Abdalla E, Hoshino K, Yamasaki H, Okubo T et al. Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2alphaB gene associated with myeloblastic leukemias. Blood 1999; 93: 1817-1824.
3. Preudhomme C, Warot-Loze D, Roumier C, Grardel-Duflos N, Garand R, Lai JL et al. High incidence of biallelic point mutations in the Runt domain of the AML1/PEBP2 alpha B gene in Mo acute myeloid leukemia and in myeloid malignancies with acquired trisomy 21. Blood 2000; 96: 2862-2869.
4. Song WJ, Sullivan MG, Legare RD, Hutchings S, Tan X, Kufrin D et al. Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia. Nat Genet 1999; 23: 166-175.
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6. Mueller BU, Pabst T, Osato M, Asou N, Johansen LM, Minden MD et al. Heterozygous PU.1 mutations are associated with acute myeloid leukemia. Blood 2002; 100: 998-1007.
7. Leroy H, Roumier C, Grardel-Duflos N, Macintyre E, Lepelley P, Fenaux P et al. Unlike AML1, CBFbeta gene is not deregulated by point mutations in acute myeloid leukemia and in myelodysplastic syndromes. Blood 2002; 99: 3848-3850.
8. Le XF, Groner Y, Kornblau SM, Gu Y, Hittelman WN, Levanon D et al. Regulation of AML2/CBFA3 in hematopoietic cells through the retinoic acid receptor alpha-dependent signaling pathway. J Biol Chem 1999; 274: 21651-21658.