Hoxa10 and Hoxd10 coordinately regulate lumbar motor neuron patterning

Journal of Neurobiology

Volumn 56, Issue 4, 2003, Pages 328-337

  Lin, Amy W ^a   Carpenter, Ellen M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Hox; Lumbar motor column; Motor neuron; Patterning; Spinal cord

Indexed keywords

GENE PRODUCT; PROTEIN HOXD10; TRANSCRIPTION FACTOR HOXA10; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DISRUPTION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; GENE CONTROL; GENE EXPRESSION; GENE INACTIVATION; GENE MUTATION; KIDNEY; LUMBAR SPINAL CORD; MESODERM; MOTONEURON; MOUSE; NERVE GROWTH; NONHUMAN; PERIPHERAL NERVE; PRIORITY JOURNAL; PROTEIN DOMAIN; SPINAL CORD; SPINAL NERVE; VASCULARIZATION;

ANIMALS; BODY PATTERNING; CELL COUNT; GENE DELETION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HOMEODOMAIN PROTEINS; KIDNEY; LUMBAR VERTEBRAE; MICE; MICE, MUTANT STRAINS; MOTOR NEURONS; TRANSCRIPTION FACTORS; ZEBRAFISH PROTEINS;

EID: 0042009471     PISSN: 00223034     EISSN: None     Source Type: Journal    
DOI: 10.1002/neu.10239     Document Type: Article

References (29)

1. Awgulewitsch A, Jacobs D. 1990. Differential expression of Hox 3.1 protein in subregions of the embryonic and adult spinal cord. Development 108:411-420.
2. Boudreau N, Andrews C, Srebrow A, Ravanpay A, Cheresh DA. 1997. Induction of the angiogenic phenotype by Hox D3. J Cell Biol 139:257-264.
3. Briscoe J, Ericson J. 2001. Specification of neuronal fates in the ventral neural tube. Curr Opin Neurobiol 11:43-49.
4. Burke AC, Tabin CJ. 1996. Vitally mediated misexpression of Hoxc-6 in the cervical mesoderm results in spinal nerve truncations. Dev Biol 178:92-197.
5. Carpenter EM. 2002. Hox genes and spinal cord development. Dev Neurosci 24:24-34.
6. Carpenter EM, Goddard JM, Chisaka O, Manley NR, Capecchi MR. 1993. Loss of Hox-A1 (Hox-1.6) function results in the reorganization of the murine hindbrain. Development 118:1063-1075.
7. Carpenter EM, Goddard JM, Davis AP, Nguyen TP, Capecchi MR. 1997. Targeted disruption of Hoxd-10 affects mouse hindlimb development. Development 124:4505-4514.
8. de la Cruz CC, Der-Avakian A, Spyropoulos D, Tieu DD, Carpenter EM. 1999. Targeted disruption of Hoxd9 and Hoxd10 alters locomotor behavior, vertebral identity, and peripheral nervous system development. Dev Biol 216:595-610.
9. Deschamps J, Wijgerde M. 1993. Two phases inn the establishment of HOX expression domains. Dev Biol 156:473-480.
10. Ensini M, Tsuchida TM, Belting H-G, Jessell TM. 1998. The control of rostrocaudal pattern in the developing spinal cord: specification of motor neuron subtype identity is initiated by signals from paraxial mesoderm. Development 125:969-982.
11. Favier B, Rijli FM, Fromental-Ramain C, Fraulob V, Chambon P, Dollé P. 1996. Functional cooperation between the non-paralogous genes Hoxa-10 and Hoxd-11 in the developing forelimb and axial skeleton. Development 122:449-460.
12. Fromental-Ramain C, Warot X, Lakkaraju S, Favier B, Haack H, Birling C, Dierich A, Dollé P, Chambon P. 1996. Specific and redundant functions of the paralogous Hoxa-9 and Hoxd-9 genes in forelimb and axial skeleton patterning. Development 122:461-472.
13. Gavalas A, Studer M, Lumsden A, Rijli F, Krumlauf R, Chambon P. 1998. Hoxa1 and Hoxb1 synergize in patterning the hindbrain, cranial nerves and second pharyngeal arch. Development 125:1123-1136.
14. Goddard JM, Rossel M, Manley NR, Capecchi MR. 1996. Mice with targeted disruption of Hoxb-1 fail to form the motor nucleus of the VIIth nerve. Development 122:3217-3228.
15. Hollyday M. 1980. Organization of motor pools in the chick lumbar lateral motor column. J Comp Neurol 194:143-170.
16. Hostikka SL, Capecchi MR. 1998. The mouse Hoxc11 gene: genomic structure and expression pattern. Mech Dev 70:133-145.
17. Lance-Jones C. 1982. Motoneuron cell death in the developing lumbar spinal cord of mouse. Dev Brain Res 4:473-479.
18. Lance-Jones C, Omelchenko N, Bailis A, Lynch S, Sharma K. 2001. Hoxd10 induction and regionalization in the developing lumbosacral spinal cord. Development 128:2255-2268.
19. Le Mouellic H, Lallemand Y, Brulet P. 1992. Homeosis in the mouse induced by a null mutation in the Hox-3.1 gene. Cell 69:251-264.
20. Liem KF, Tremml G, Roelink H, Jessell TM. 1995. Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm. Cell 82:969-979.
21. Liu J-P, Laufer E, Jessell TM. 2001. Assigning the positional identity of spinal motor neurons: rostrocaudal patterning of Hox-c expression by FGFs, Gdf11, and retinoids. Neuron 32:997-1012.
22. McHanwell S, Biscoe TJ. 1981. The localization of motoneurons supplying the hindlimb muscles of the mouse. Phil Trans R Soc Lond B 293:477-508.
23. Myers C, Charboneau A, Boudreau N. 2000. Homeobox B3 promotes capillary morphogenesis and angiogenesis. J Cell Biol 148:343-351.
24. Peterson RL, Papenbrock T, Davda MM, Awgulewitsch A. 1994. The murine Hoxc cluster contains five neighboring AbdB-related Hox genes that show unique spatially coordinated expression in posterior embryonic subregions. Mech Dev 47:253-260.
25. Rancourt DE, Tsuzuki T, Capecchi MR. 1995. Genetic interaction between hoxb-5 and hoxb-6 is revealed by nonallelic noncomplementation. Genes Dev 9:108-122.
26. Rijli FM, Matyas R, Pellegrini M, Dierich A, Gruss P, Dollé P, Chambon P. 1995. Cryptorchidism and homeotic transformations of spinal nerves and vertebrae in Hoxa-10 mutant mice. Proc Natl Acad Sci USA 92:8185-8189.
27. Romanes GJ. 1951. The motor cell columns of the lumbosacral spinal cord of the cat. J Comp Neurol 94:313-363.
28. Tiret L, Le Mouellic H, Brulet P. 1998. Increased apoptosis of motoneurons and altered somatotopic maps in the brachial spinal cord of Hoxc-8-deficient mice. Development 125:279-291.
29. Wahba GM, Hostikka SL, Carpenter EM. 2001. The paralogous Hox genes Hoxa10 and Hoxd10 interact to pattern the mouse hindlimb peripheral nervous system and skeleton. Dev Biol 231:87-102.