Linkage analysis suggests a locus of ichthyosis vulgaris on 1q22

Journal of Human Genetics

Volumn 48, Issue 7, 2003, Pages 390-392

  Zhong, Wei ^a,b   Cui, Bin ^a,c   Zhang, Yizhi ^d   Jiang, Haisong ^a   Wei, Shengcai ^a   Bu, Lei ^a   Zhao, Guoping ^b   Hu, Landian ^a   Kong, Xiangyin ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b INSTITUTE OF PLANT PHYSIOLOGY AND ECOLOGY   (China)

^c SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^d SICHUAN UNIVERSITY   (China)

Author keywords

Chromosome 1; Epidermal differentiation complex (EDC); Ichthyosis vulgaris (IV); Linkage; Lod score; Skin disorder

Indexed keywords

ARTICLE; CHINESE; CHROMOSOMAL LOCALIZATION; CHROMOSOME 1Q; FAMILY STUDY; GENE IDENTIFICATION; GENE LOCUS; GENETIC LINKAGE; HUMAN; ICHTHYOSIS VULGARIS; LINKAGE ANALYSIS;

CHINA; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 1; FAMILY HEALTH; FEMALE; GENETIC MARKERS; HAPLOTYPES; HUMANS; ICHTHYOSIS VULGARIS; LINKAGE (GENETICS); LOD SCORE; MALE; MICROSATELLITE REPEATS; PEDIGREE;

EID: 0041971159     PISSN: 14345161     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10038-003-0043-1     Document Type: Article

References (12)

1. Compton JG, DiGiovanna JJ, Johnston KA, Fleckman P, Bale SJ (2002) Mapping of the associated phenotype of an absent granular layer in ichthyosis vulgaris to the epidermal differentiation complex on chromosome 1. Exp Dermatol 11:518-526
2. Cottingham RW Jr, Idury RM, Schaffer AA (1993) Faster sequential genetic linkage computations. Am J Hum Genet 53:252-263
3. Hernandez-Martin A, Gonzalez-Sarmiento R, De Unamuno P (1999) X-linked ichthyosis: an update. Br J Dermatol 141:617-627
4. Lathrop GM, Lalouel JM, Julier C, Ott J (1984) Strategies for multilocus linkage analysis in humans. Proc Natl Acad Sci USA 81:3443-3446
5. Lei G, Zhang Y, Hu Y (1992) Investigation on the prevalence of Ichthyosis in Sichuan Province. Chin J Dermatol (in Chinese) 25:105-106
6. Marenholz I, Volz A, Ziegler A, Davies A, Ragoussis I, Korge BP, Mischke D (1996) Genetic analysis of the epidermal differentiation complex (EDC) on human chromosome 1q21: chromosomal orientation, new markers, and a 6-Mb YAC contig. Genomics 37:295-302
7. Nirunsuksiri W, Presland RB, Brumbaugh SG, Dale BA, Fleckman P (1995) Decreased profilaggrin expression in ichthyosis vulgaris is a result of selectively impaired posttranscriptional control. J Biol Chem 270:871-876
8. Okano M, Kitano Y, Yoshikawa K, Nakamura T, Matsuzawa Y, Yuasa T (1988) X-linked ichthyosis and ichthyosis vulgaris: comparison of their clinical features based on biochemical analysis. Br J Dermatol 119:777-783
9. Presland RB, Boggess D, Lewis SP, Hull C, Fleckman P, Sundberg JP (2000) Loss of normal profilaggrin and filaggrin in flaky tail (ft/ft) mice: an animal model for the filaggrin-deficient skin disease ichthyosis vulgaris. J Invest Dermatol 115:1072-1081
10. Schaffer AA, Gupta SK, Shriram K, Cottingham RW Jr (1994) Avoiding recomputation in linkage analysis. Hum Hered 44:225-237
11. Sobel E, Lange K (1996) Descent graphs in pedigree analysis: applications to haplotyping, location scores, and marker-sharing statistics. Am J Hum Genet 58:1323-1337
12. Wells RS, Kerr CB (1966) Clinical features of autosomal dominant and sex-linked ichthyosis in an English population. Br Med J 1:947-950