Characterization of the BclI polymorphism in the glucocorticoid receptor gene

Clinical Chemistry

Volumn 49, Issue 9, 2003, Pages 1528-1531

  Fleury, Isabelle ^a   Beaulieu, Patrick ^a   Primeau, Melanie ^a   Labuda, Damian ^a,b   Sinnett, Daniel ^a,b   Krajinovic, Maja ^a,b  

^a UNIVERSITY OF MONTREAL   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BCL 1 PROTEIN; CORTICOSTEROID; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; DNA POLYMORPHISM; DNA PROBE; GENETIC VARIABILITY; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SIDE EFFECT; SOUTHERN BLOTTING;

DEOXYRIBONUCLEASES, TYPE II SITE-SPECIFIC; HUMANS; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; RECEPTORS, GLUCOCORTICOID;

EID: 0041942559     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: 10.1373/49.9.1528     Document Type: Article

References (19)

1. Schimmer BP, Parker KL. Adrenocorticotropic hormone; adrenocortical steroids and their synthetic analogs. In: Hardmam JG, Limbird LE, Gilman AG, eds. The pharmacological basis of therapeutics, 10th ed. New York: McGraw-Hill, 1996:1649-78.
2. Greenstein S, Ghias K, Krett NL, Rosen ST. Mechanisms of glucocorticoid-mediated apoptosis in hematological malignancies. Clin Cancer Res 2002;8:1681-94.
3. Arai K, Chrousos GP. Hormone-nuclear receptor interactions in health and disease. Glucocorticoid resistance. Baillieres Clin Endocrinol Metab 1994;8:317-31.
4. Panarelli M, Fraser R. The glucocorticoid receptor and hypertension. Endocr Res 1994;20:101-16.
5. DeRijk RH, Schaaf M, de Kloet ER. Glucocorticoid receptor variants: clinical implications. J Steroid Biochem Mol Biol 2002;81:103-22.
6. Rosmond R, Chagnon YC, Holm G, Chagnon M, Perusse L, Lindell K, et al. A glucocorticoid receptor gene marker is associated with abdominal obesity, leptin, and dysregulation of the hypothalamic-pituitary-adrenal axis. Obes Res 2000;8:211-8.
7. Huizenga NA, Koper JW, De Lange P, Pols HA, Stolk RP, Burger H, et al. A polymorphism in the glucocorticoid receptor gene may be associated with and increased sensitivity to glucocorticoids in vivo. J Clin Endocrinol Metab 1998;83:144-51.
8. Schaaf MJ, Cidlowski JA. AUUUA motifs in the 3′UTR of human glucocorticoid receptor α and β mRNA destabilize mRNA and decrease receptor protein expression. Steroids 2002;67:627-36.
9. Murray JC, Smith RF, Ardinger HA, Weinberger C. RFLP for the glucocorticoid receptor (GRL) located at 5q11-5q13. Nucleic Acids Res 1987;15:6765.
10. Panarelli M, Holloway CD, Fraser R, Connell JM, Ingram MC, Anderson NH, et al. Glucocorticoid receptor polymorphism, skin vasoconstriction, and other metabolic intermediate phenotypes in normal human subjects. J Clin Endocrinol Metab 1998;83:1846-52.
11. Ukkola O, Perusse L, Chagnon YC, Despres JP, Bouchard C. Interactions among the glucocorticoid receptor, lipoprotein lipase and adrenergic receptor genes and abdominal fat in the Quebec Family Study. Int J Obes Relat Metab Disord 2001;25:1332-9.
12. Buemann B, Vohl MC, Chagnon M, Chagnon YC, Gagnon J, Perusse L, et al. Abdominal visceral fat is associated with a BclI restriction fragment length polymorphism at the glucocorticoid receptor gene locus. Obes Res 1997;5:186-92.
13. Weaver JU, Hitman GA, Kopelman PG. An association between a Bc1I restriction fragment length polymorphism of the glucocorticoid receptor locus and hyperinsulinaemia in obese women. J Mol Endocrinol 1992;9:295-300.
14. Ukkola O, Rosmond R, Tremblay A, Bouchard C. Glucocorticoid receptor Bcl I variant is associated with an increased atherogenic profile in response to long-term overfeeding. Atherosclerosis 2001;157:221-4.
15. Watt GC, Harrap SB, Foy CJ, Holton DW, Edwards HV, Davidson HR, et al. Abnormalities of glucocorticoid metabolism and the renin-angiotensin system: a four-corners approach to the identification of genetic determinants of blood pressure. J Hypertens 1992;10:473-82.
16. Grenett HE, Khan N, Jiang W, Booyse FM. Identification of the Hind III polymorphic site in the PAI-1 gene: analysis of the PAI-1 Hind III polymorphism by PCR. Genet Test 2000;4:65-8.
17. Metes D, Gambotto AA, Nellis J, Ruscin A, Stewart-Akers AM, Morel PA, et al. Identification of the CD32/FcgammaRIlc-Q13/STP13 polymorphism using an allele-specific restriction enzyme digestion assay. J Immunol Methods 2001;258:85-95.
18. Gold B. Origin and utility of the reverse dot-blot. Expert Rev Mol Diagn 2003;3:143-52.
19. Labuda D, Krajinovic M, Richer C, Skoll A, Sinnett H, Yotova V, et al. Rapid detection of CYP1A1, CYP2D6, and NAT variants by multiplex polymerase chain reaction and allele-specific oligonucleotide assay. Anal Biochem 1999;275:84-92.