메뉴 건너뛰기




Volumn 9, Issue 8, 2003, Pages 331-338

Molecular and cellular basis for designing gene vaccines against inflammatory autoimmune disease

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 4; VACCINE;

EID: 0041926322     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4914(03)00134-5     Document Type: Article
Times cited : (8)

References (76)
  • 1
    • 85031077187 scopus 로고    scopus 로고
    • A molecule solves psoriasis? Systemic therapies for psoriasis inducing interleukin 4 and Th2 responses
    • in press
    • Ghoreschi, K. et al. A molecule solves psoriasis? Systemic therapies for psoriasis inducing interleukin 4 and Th2 responses. J. Mol. Med. (in press)
    • J. Mol. Med.
    • Ghoreschi, K.1
  • 2
    • 0035954658 scopus 로고    scopus 로고
    • New treatments for psoriasis
    • Granstein, R.D. (2001) New treatments for psoriasis. N. Engl. J. Med. 345, 284-287
    • (2001) N. Engl. J. Med. , vol.345 , pp. 284-287
    • Granstein, R.D.1
  • 3
    • 0029847368 scopus 로고    scopus 로고
    • Functional diversity of helper T lymphocytes
    • Abbas, A.K. et al. (1996) Functional diversity of helper T lymphocytes. Nature 383, 787-793
    • (1996) Nature , vol.383 , pp. 787-793
    • Abbas, A.K.1
  • 4
    • 0026584817 scopus 로고
    • + T cells toward a Th1 or Th2 functional phenotype
    • + T cells toward a Th1 or Th2 functional phenotype. J. Immunol. 148, 47-54
    • (1992) J. Immunol. , vol.148 , pp. 47-54
    • Rocken, M.1
  • 5
    • 0036885067 scopus 로고    scopus 로고
    • The lineage decisions of helper T cells
    • Murphy, K.M. and Reiner, S.L. (2002) The lineage decisions of helper T cells. Nat. Rev. Immunol. 2, 933-944
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 933-944
    • Murphy, K.M.1    Reiner, S.L.2
  • 6
    • 8044250881 scopus 로고    scopus 로고
    • Regulation of the interleukin (IL)-12R β2 subunit expression in developing T helper 1 (Th1) and Th2 cells
    • Szabo, S.J. et al. (1997) Regulation of the interleukin (IL)-12R β2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J. Exp. Med. 185, 817-824
    • (1997) J. Exp. Med. , vol.185 , pp. 817-824
    • Szabo, S.J.1
  • 7
    • 0030810155 scopus 로고    scopus 로고
    • The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells
    • Zheng, W. and Flavell, R.A. (1997) The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 89, 587-596
    • (1997) Cell , vol.89 , pp. 587-596
    • Zheng, W.1    Flavell, R.A.2
  • 8
    • 0033427612 scopus 로고    scopus 로고
    • Ectopic expression of activated Stat6 induces the expression of Th2-specific cytokines and transcription factors in developing Th1 cells
    • Kurata, H. et al. (1999) Ectopic expression of activated Stat6 induces the expression of Th2-specific cytokines and transcription factors in developing Th1 cells. Immunity 11, 677-688
    • (1999) Immunity , vol.11 , pp. 677-688
    • Kurata, H.1
  • 9
    • 0033973582 scopus 로고    scopus 로고
    • Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment
    • Ouyang, W. et al. (2000) Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment. Immunity 12, 27-37
    • (2000) Immunity , vol.12 , pp. 27-37
    • Ouyang, W.1
  • 10
    • 0032433127 scopus 로고    scopus 로고
    • + T cells in the antitumor immune response
    • + T cells in the antitumor immune response. J. Exp. Med. 188, 2357-2368
    • (1998) J. Exp. Med. , vol.188 , pp. 2357-2368
    • Hung, K.1
  • 12
    • 0034653709 scopus 로고    scopus 로고
    • Eradication of disseminated lymphomas with CpG-DNA-activated T helper type 1 cells from nontransgenic mice
    • Egeter, O. et al. (2000) Eradication of disseminated lymphomas with CpG-DNA-activated T helper type 1 cells from nontransgenic mice. Cancer Res. 60, 1515-1520
    • (2000) Cancer Res. , vol.60 , pp. 1515-1520
    • Egeter, O.1
  • 13
    • 0028890866 scopus 로고
    • + T cells in the pathogenesis of organ-specific autoimmune diseases
    • + T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol. Today 16, 34-38
    • (1995) Immunol. Today , vol.16 , pp. 34-38
    • Liblau, R.S.1
  • 14
    • 0343773445 scopus 로고    scopus 로고
    • IL-4-induced immune deviation as antigen-specific therapy for inflammatory autoimmune disease
    • Rocken, M. et al. (1996) IL-4-induced immune deviation as antigen-specific therapy for inflammatory autoimmune disease. Immunol. Today 17, 225-231
    • (1996) Immunol. Today , vol.17 , pp. 225-231
    • Rocken, M.1
  • 15
    • 0026611671 scopus 로고
    • The importance of Th2 cytokines in protective immunity to nematodes
    • Urban, J.F.J. et al. (1992) The importance of Th2 cytokines in protective immunity to nematodes. Immunol. Rev. 127, 205-220
    • (1992) Immunol. Rev. , vol.127 , pp. 205-220
    • Urban, J.F.J.1
  • 16
    • 0028006251 scopus 로고
    • Cytokine-mediated regulation of chronic intestinal helminth infection
    • Else, K.J. et al. (1994) Cytokine-mediated regulation of chronic intestinal helminth infection. J. Exp. Med. 179, 347-351
    • (1994) J. Exp. Med. , vol.179 , pp. 347-351
    • Else, K.J.1
  • 17
    • 0028116618 scopus 로고
    • Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease
    • Racke, M.K. et al. (1994) Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease. J. Exp. Med. 180, 1961-1966
    • (1994) J. Exp. Med. , vol.180 , pp. 1961-1966
    • Racke, M.K.1
  • 18
    • 0035007878 scopus 로고    scopus 로고
    • Reversal of established delayed type hypersensitivity reactions following therapy with IL-4 or antigen-specific Th2 cells
    • Biedermann, T. et al. (2001) Reversal of established delayed type hypersensitivity reactions following therapy with IL-4 or antigen-specific Th2 cells. Eur. J. Immunol. 31, 1582-1591
    • (2001) Eur. J. Immunol. , vol.31 , pp. 1582-1591
    • Biedermann, T.1
  • 19
    • 0027537583 scopus 로고
    • A population-based study of multiple sclerosis in twins: Update
    • Sadovnick, A.D. et al. (1993) A population-based study of multiple sclerosis in twins: update. Ann. Neurol. 33, 281-285
    • (1993) Ann. Neurol. , vol.33 , pp. 281-285
    • Sadovnick, A.D.1
  • 20
    • 0023757321 scopus 로고
    • The significance of the concordance rate for type 1 (insulin-dependent) diabetes in identical twins
    • Olmos, P. et al. (1988) The significance of the concordance rate for type 1 (insulin-dependent) diabetes in identical twins. Diabetologia 31, 747-750
    • (1988) Diabetologia , vol.31 , pp. 747-750
    • Olmos, P.1
  • 21
    • 0346599403 scopus 로고    scopus 로고
    • An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. The Finnish-German APECED consortium. Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy
    • Anonymous, (1997) An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. The Finnish-German APECED consortium. Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Nat. Genet. 17, 399-403
    • (1997) Nat. Genet. , vol.17 , pp. 399-403
  • 23
    • 0032695108 scopus 로고    scopus 로고
    • Natural adjuvants: Endogenous activators of dendritic cells
    • Gallucci, S. et al. (1999) Natural adjuvants: endogenous activators of dendritic cells. Nat. Med. 5, 1249-1255
    • (1999) Nat. Med. , vol.5 , pp. 1249-1255
    • Gallucci, S.1
  • 24
    • 0026775464 scopus 로고
    • Infection breaks T-cell tolerance
    • Rocken, M. et al. (1992) Infection breaks T-cell tolerance. Nature 359, 79-82
    • (1992) Nature , vol.359 , pp. 79-82
    • Rocken, M.1
  • 25
    • 0037073930 scopus 로고    scopus 로고
    • Maintenance of serological memory by polyclonal activation of human memory B cells
    • Bernasconi, N.L. et al. (2002) Maintenance of serological memory by polyclonal activation of human memory B cells. Science 298, 2199-2202
    • (2002) Science , vol.298 , pp. 2199-2202
    • Bernasconi, N.L.1
  • 26
    • 0037083298 scopus 로고    scopus 로고
    • Microbial compounds selectively induce Th1 cell-promoting or Th2 cell-promoting dendritic cells in vitro with diverse Th cell-polarizing signals
    • de Jong, E.C. et al. (2002) Microbial compounds selectively induce Th1 cell-promoting or Th2 cell-promoting dendritic cells in vitro with diverse Th cell-polarizing signals. J. Immunol. 168, 1704-1709
    • (2002) J. Immunol. , vol.168 , pp. 1704-1709
    • De Jong, E.C.1
  • 27
    • 0030963666 scopus 로고    scopus 로고
    • Human dendritic cells require exogenous interleukin-12-inducing factors to direct the development of naive T-helper cells toward the Th1 phenotype
    • Hilkens, C.M. et al. (1997) Human dendritic cells require exogenous interleukin-12-inducing factors to direct the development of naive T-helper cells toward the Th1 phenotype. Blood 90, 1920-1926
    • (1997) Blood , vol.90 , pp. 1920-1926
    • Hilkens, C.M.1
  • 28
    • 0031867535 scopus 로고    scopus 로고
    • Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells
    • Sparwasser, T. et al. (1998) Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells. Eur. J. Immunol. 28, 2045-2054
    • (1998) Eur. J. Immunol. , vol.28 , pp. 2045-2054
    • Sparwasser, T.1
  • 29
    • 0034619794 scopus 로고    scopus 로고
    • A Toll-like receptor recognizes bacterial DNA
    • Hemmi, H. et al. (2000) A Toll-like receptor recognizes bacterial DNA. Nature 408, 740-745
    • (2000) Nature , vol.408 , pp. 740-745
    • Hemmi, H.1
  • 30
    • 0030966184 scopus 로고    scopus 로고
    • Circulating T cells of patients with active psoriasis respond to streptococcal M-peptides sharing sequences with human epidermal keratins
    • Sigmundsdottir, H. et al. (1997) Circulating T cells of patients with active psoriasis respond to streptococcal M-peptides sharing sequences with human epidermal keratins. Scand. J. Immunol. 45, 688-697
    • (1997) Scand. J. Immunol. , vol.45 , pp. 688-697
    • Sigmundsdottir, H.1
  • 31
    • 0035723611 scopus 로고    scopus 로고
    • Psoriasis vulgaris - A sterile antibacterial skin reaction mediated by cross-reactive T cells? An immunological view of the pathophysiology of psoriasis
    • Prinz, J.C. (2001) Psoriasis vulgaris - a sterile antibacterial skin reaction mediated by cross-reactive T cells? An immunological view of the pathophysiology of psoriasis. Clin. Exp. Dermatol. 26, 326-332
    • (2001) Clin. Exp. Dermatol. , vol.26 , pp. 326-332
    • Prinz, J.C.1
  • 32
    • 0028926223 scopus 로고
    • Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein
    • Wucherpfennig, K.W. and Strominger, J.L. (1995) Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell 80, 695-705
    • (1995) Cell , vol.80 , pp. 695-705
    • Wucherpfennig, K.W.1    Strominger, J.L.2
  • 33
    • 0032915806 scopus 로고    scopus 로고
    • Molecular mimicry and multiple sclerosis: Degenerate T-cell recognition and the induction of autoimmunity
    • Gran, B. et al. (1999) Molecular mimicry and multiple sclerosis: degenerate T-cell recognition and the induction of autoimmunity. Ann. Neurol. 45, 559-567
    • (1999) Ann. Neurol. , vol.45 , pp. 559-567
    • Gran, B.1
  • 34
    • 0028007192 scopus 로고
    • Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes
    • Atkinson, M.A. et al. (1994) Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes. J. Clin. Invest. 94, 2125-2129
    • (1994) J. Clin. Invest. , vol.94 , pp. 2125-2129
    • Atkinson, M.A.1
  • 35
    • 0007102288 scopus 로고    scopus 로고
    • Identification of naturally processed T cell epitopes from glutamic acid decarboxylase presented in the context of HLA-DR alleles by T lymphocytes of recent onset IDDM patients
    • Endl, J. et al. (1997) Identification of naturally processed T cell epitopes from glutamic acid decarboxylase presented in the context of HLA-DR alleles by T lymphocytes of recent onset IDDM patients. J. Clin. Invest. 99, 2405-2415
    • (1997) J. Clin. Invest. , vol.99 , pp. 2405-2415
    • Endl, J.1
  • 36
    • 0032840183 scopus 로고    scopus 로고
    • Analysis of antibody responses against coxsackie virus B4 protein 2C and the diabetes autoantigen GAD(65)
    • Vreugdenhil, G.R. et al. (1999) Analysis of antibody responses against coxsackie virus B4 protein 2C and the diabetes autoantigen GAD(65). J. Med. Virol. 59, 256-261
    • (1999) J. Med. Virol. , vol.59 , pp. 256-261
    • Vreugdenhil, G.R.1
  • 37
    • 0027176158 scopus 로고
    • Inverse relation between humoral and cellular immunity to glutamic acid decarboxylase in subjects at risk of insulin-dependent diabetes
    • Harrison, L.C. et al. (1993) Inverse relation between humoral and cellular immunity to glutamic acid decarboxylase in subjects at risk of insulin-dependent diabetes. Lancet 341, 1365-1369
    • (1993) Lancet , vol.341 , pp. 1365-1369
    • Harrison, L.C.1
  • 38
    • 0031874342 scopus 로고    scopus 로고
    • Diabetes induced by Coxsackie virus: Initiation by bystander damage and not molecular mimicry
    • Horwitz, M.S. et al. (1998) Diabetes induced by Coxsackie virus: initiation by bystander damage and not molecular mimicry. Nat. Med. 4, 781-785
    • (1998) Nat. Med. , vol.4 , pp. 781-785
    • Horwitz, M.S.1
  • 39
    • 0031011146 scopus 로고    scopus 로고
    • Experimental autoimmune encephalomyelitis in IL-4-deficient mice
    • Liblau, R. et al. (1997) Experimental autoimmune encephalomyelitis in IL-4-deficient mice. Int. Immunol. 9, 799-803
    • (1997) Int. Immunol. , vol.9 , pp. 799-803
    • Liblau, R.1
  • 40
    • 0038496773 scopus 로고    scopus 로고
    • + T cells within dendritic cell clusters
    • + T cells within dendritic cell clusters. Eur. J. Immunol. 33, 1686-1696
    • (2003) Eur. J. Immunol. , vol.33 , pp. 1686-1696
    • Creusot, R.J.1
  • 41
    • 0037820460 scopus 로고    scopus 로고
    • Th2 cells shape the differentiation of developing T cell responses during interactions with dendritic cells in vivo
    • Schipf, A. et al. (2003) Th2 cells shape the differentiation of developing T cell responses during interactions with dendritic cells in vivo. Eur. J. Immunol. 33, 1697-1706
    • (2003) Eur. J. Immunol. , vol.33 , pp. 1697-1706
    • Schipf, A.1
  • 42
    • 0028339765 scopus 로고
    • Antigen-specific activation, tolerization, and reactivation of the interleukin 4 pathway in vivo
    • Rocken, M. et al. (1994) Antigen-specific activation, tolerization, and reactivation of the interleukin 4 pathway in vivo. J. Exp. Med. 179, 1885-1893
    • (1994) J. Exp. Med. , vol.179 , pp. 1885-1893
    • Rocken, M.1
  • 43
    • 0030918701 scopus 로고    scopus 로고
    • Local delivery of interleukin 4 by retrovirus-transduced T lymphocytes ameliorates experimental autoimmune encephalomyelitis
    • Shaw, M.K. et al. (1997) Local delivery of interleukin 4 by retrovirus-transduced T lymphocytes ameliorates experimental autoimmune encephalomyelitis. J. Exp. Med. 185, 1711-1714
    • (1997) J. Exp. Med. , vol.185 , pp. 1711-1714
    • Shaw, M.K.1
  • 44
    • 0034985881 scopus 로고    scopus 로고
    • Expression of interleukin-4 but not of interleukin-10 from a replicative herpes simplex virus type 1 viral vector precludes experimental allergic encephalomyelitis
    • Broberg, E. et al. (2001) Expression of interleukin-4 but not of interleukin-10 from a replicative herpes simplex virus type 1 viral vector precludes experimental allergic encephalomyelitis. Gene Ther. 8, 769-777
    • (2001) Gene Ther. , vol.8 , pp. 769-777
    • Broberg, E.1
  • 45
    • 0037254145 scopus 로고    scopus 로고
    • Immunomodulation of experimental autoimmune encephalomyelitis by helminth ova immunization
    • Sewell, D. et al. (2003) Immunomodulation of experimental autoimmune encephalomyelitis by helminth ova immunization. Int. Immunol. 15, 59-69
    • (2003) Int. Immunol. , vol.15 , pp. 59-69
    • Sewell, D.1
  • 46
    • 0024502120 scopus 로고
    • Murine interleukin-4 displays potent antitumor activity in vivo
    • Tepper, R.I. et al. (1989) Murine interleukin-4 displays potent antitumor activity in vivo. Cell 57, 503-512
    • (1989) Cell , vol.57 , pp. 503-512
    • Tepper, R.I.1
  • 47
    • 0026331269 scopus 로고
    • Treatment of established renal cancer by tumor cells engineered to secrete interleukin-4
    • Golumbek, P.T. et al. (1991) Treatment of established renal cancer by tumor cells engineered to secrete interleukin-4. Science 254, 713-716
    • (1991) Science , vol.254 , pp. 713-716
    • Golumbek, P.T.1
  • 48
    • 0025222698 scopus 로고
    • IL-4 directs the development of Th2-like helper effectors
    • Swain, S.L. et al. (1990) IL-4 directs the development of Th2-like helper effectors. J. Immunol. 145, 3796-3806
    • (1990) J. Immunol. , vol.145 , pp. 3796-3806
    • Swain, S.L.1
  • 49
    • 0025082313 scopus 로고
    • Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells
    • Le Gros, G. et al. (1990) Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells. J. Exp. Med. 172, 921-929
    • (1990) J. Exp. Med. , vol.172 , pp. 921-929
    • Le Gros, G.1
  • 50
    • 0028179006 scopus 로고
    • Lymphocyte responses and cytokines
    • Paul, W.E. and Seder, R.A. (1994) Lymphocyte responses and cytokines. Cell 76, 241-251
    • (1994) Cell , vol.76 , pp. 241-251
    • Paul, W.E.1    Seder, R.A.2
  • 51
    • 0033802387 scopus 로고    scopus 로고
    • Interleukin (IL)-4 is a major regulatory cytokine governing bioactive IL-12 production by mouse and human dendritic cells
    • Hochrein, H. et al. (2000) Interleukin (IL)-4 is a major regulatory cytokine governing bioactive IL-12 production by mouse and human dendritic cells. J. Exp. Med. 192, 823-833
    • (2000) J. Exp. Med. , vol.192 , pp. 823-833
    • Hochrein, H.1
  • 52
    • 0035172957 scopus 로고    scopus 로고
    • IL-4 instructs Th1 responses and resistance to Leishmania major in susceptible BALB/c mice
    • Biedermann, T. et al. (2001) IL-4 instructs Th1 responses and resistance to Leishmania major in susceptible BALB/c mice. Nat. Immunol. 2, 1054-1060
    • (2001) Nat. Immunol. , vol.2 , pp. 1054-1060
    • Biedermann, T.1
  • 53
    • 0035122430 scopus 로고    scopus 로고
    • IL-4 triggers autoimmune diabetes by increasing self-antigen presentation within the pancreatic islets
    • Falcone, M. et al. (2001) IL-4 triggers autoimmune diabetes by increasing self-antigen presentation within the pancreatic islets. Clin. Immunol. 98, 190-199
    • (2001) Clin. Immunol. , vol.98 , pp. 190-199
    • Falcone, M.1
  • 54
    • 0029839059 scopus 로고    scopus 로고
    • + T cells, analyzed at the single-cell level
    • + T cells, analyzed at the single-cell level. J. Exp. Med. 184, 473-483
    • (1996) J. Exp. Med. , vol.184 , pp. 473-483
    • Sornasse, T.1
  • 55
    • 0029809476 scopus 로고    scopus 로고
    • A strict requirement of interleukin-4 for interleukin-4 induction in antigen-stimulated human memory T cells
    • Breit, S. et al. (1996) A strict requirement of interleukin-4 for interleukin-4 induction in antigen-stimulated human memory T cells. Eur. J. Immunol. 26, 1860-1865
    • (1996) Eur. J. Immunol. , vol.26 , pp. 1860-1865
    • Breit, S.1
  • 56
    • 0032729645 scopus 로고    scopus 로고
    • The majority of epidermal T cells in psoriasis vulgaris lesions can produce type 1 cytokines, interferon-γ, interleukin-2, and tumor necrosis factor-α, defining TC1 (cytotoxic T lymphocyte) and Th1 effector populations: A type 1 differentiation bias is also measured in circulating blood T cells in psoriatic patients
    • Austin, L.M. et al. (1999) The majority of epidermal T cells in psoriasis vulgaris lesions can produce type 1 cytokines, interferon-γ, interleukin-2, and tumor necrosis factor-α, defining TC1 (cytotoxic T lymphocyte) and Th1 effector populations: a type 1 differentiation bias is also measured in circulating blood T cells in psoriatic patients. J. Invest. Dermatol. 113, 752-759
    • (1999) J. Invest. Dermatol. , vol.113 , pp. 752-759
    • Austin, L.M.1
  • 57
    • 0037234390 scopus 로고    scopus 로고
    • Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease
    • Ghoreschi, K. et al. (2003) Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease. Nat. Med. 9, 40-46
    • (2003) Nat. Med. , vol.9 , pp. 40-46
    • Ghoreschi, K.1
  • 58
    • 0029143764 scopus 로고
    • Evidence for an antigen-specific cellular immune response in skin lesions of patients with psoriasis vulgaris
    • Menssen, A. et al. (1995) Evidence for an antigen-specific cellular immune response in skin lesions of patients with psoriasis vulgaris. J. Immunol. 155, 4078-4083
    • (1995) J. Immunol. , vol.155 , pp. 4078-4083
    • Menssen, A.1
  • 59
    • 0025866672 scopus 로고
    • CD4 antibody treatment of severe psoriasis
    • Nicolas, J.F. et al. (1991) CD4 antibody treatment of severe psoriasis. Lancet 338, 321
    • (1991) Lancet , vol.338 , pp. 321
    • Nicolas, J.F.1
  • 60
    • 0025862110 scopus 로고
    • Chimaeric CD4 monoclonal antibody in treatment of generalised pustular psoriasis
    • Prinz, J. et al. (1991) Chimaeric CD4 monoclonal antibody in treatment of generalised pustular psoriasis. Lancet 338, 320-321
    • (1991) Lancet , vol.338 , pp. 320-321
    • Prinz, J.1
  • 61
    • 0035832515 scopus 로고    scopus 로고
    • Efficacy and safety of infliximab monotherapy for plaque-type psoriasis: A randomised trial
    • Chaudhari, U. et al. (2001) Efficacy and safety of infliximab monotherapy for plaque-type psoriasis: a randomised trial. Lancet 357, 1842-1847
    • (2001) Lancet , vol.357 , pp. 1842-1847
    • Chaudhari, U.1
  • 62
    • 0032519956 scopus 로고    scopus 로고
    • IL-10 is a key cytokine in psoriasis. Proof of principle by IL-10 therapy: A new therapeutic approach
    • Asadullah, K. et al. (1998) IL-10 is a key cytokine in psoriasis. Proof of principle by IL-10 therapy: a new therapeutic approach. J. Clin. Invest. 101, 783-794
    • (1998) J. Clin. Invest. , vol.101 , pp. 783-794
    • Asadullah, K.1
  • 63
    • 0032458296 scopus 로고    scopus 로고
    • Treatment of psoriasis with interleukin-10
    • Reich, K. et al. (1998) Treatment of psoriasis with interleukin-10. J. Invest. Dermatol. 111, 1235-1236
    • (1998) J. Invest. Dermatol. , vol.111 , pp. 1235-1236
    • Reich, K.1
  • 64
    • 0027538181 scopus 로고
    • Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity
    • Dranoff, G. (1993) Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity. Proc. Natl. Acad. Sci. U. S. A. 90, 3539-3543
    • (1993) Proc. Natl. Acad. Sci. U. S. A. , vol.90 , pp. 3539-3543
    • Dranoff, G.1
  • 65
    • 0034663999 scopus 로고    scopus 로고
    • IL-4 is a mediator of IL-12p70 induction by human Th2 cells: Reversal of polarized Th2 phenotype by dendritic cells
    • Kalinski, P. et al. (2000) IL-4 is a mediator of IL-12p70 induction by human Th2 cells: reversal of polarized Th2 phenotype by dendritic cells. J. Immunol. 165, 1877-1881
    • (2000) J. Immunol. , vol.165 , pp. 1877-1881
    • Kalinski, P.1
  • 66
    • 0343570506 scopus 로고    scopus 로고
    • Induction of resistance to active experimental allergic encephalomyelitis by myelin basic protein-specific Th2 cell lines generated in the presence of glucocorticoids and IL-4
    • Ramirez, F. and Mason, D. (2000) Induction of resistance to active experimental allergic encephalomyelitis by myelin basic protein-specific Th2 cell lines generated in the presence of glucocorticoids and IL-4. Eur. J. Immunol. 30, 747-758
    • (2000) Eur. J. Immunol. , vol.30 , pp. 747-758
    • Ramirez, F.1    Mason, D.2
  • 67
    • 0035337721 scopus 로고    scopus 로고
    • A glutamic acid decarboxylase 65-specific Th2 cell clone immunoregulates autoimmune diabetes in nonobese diabetic mice
    • Tisch, R. et al. (2001) A glutamic acid decarboxylase 65-specific Th2 cell clone immunoregulates autoimmune diabetes in nonobese diabetic mice. J. Immunol. 166, 6925-6936
    • (2001) J. Immunol. , vol.166 , pp. 6925-6936
    • Tisch, R.1
  • 68
    • 0026515770 scopus 로고
    • + T cells producing IL-2 or IL-4
    • + T cells producing IL-2 or IL-4. J. Immunol. 148, 1031-1036
    • (1992) J. Immunol. , vol.148 , pp. 1031-1036
    • Rocken, M.1
  • 69
    • 0032476640 scopus 로고    scopus 로고
    • Cytokine secretion of myelin basic protein reactive T cells in patients with multiple sclerosis
    • Windhagen, A. et al. (1998) Cytokine secretion of myelin basic protein reactive T cells in patients with multiple sclerosis. J. Neuroimmunol. 91, 1-9
    • (1998) J. Neuroimmunol. , vol.91 , pp. 1-9
    • Windhagen, A.1
  • 70
    • 0033721160 scopus 로고    scopus 로고
    • Immunotherapy of spontaneous type 1 diabetes in nonobese diabetic mice by systemic interleukin-4 treatment employing adenovirus vector-mediated gene transfer
    • Cameron, M.J. et al. (2000) Immunotherapy of spontaneous type 1 diabetes in nonobese diabetic mice by systemic interleukin-4 treatment employing adenovirus vector-mediated gene transfer. Gene Ther. 7, 1840-1846
    • (2000) Gene Ther. , vol.7 , pp. 1840-1846
    • Cameron, M.J.1
  • 71
    • 0030879734 scopus 로고    scopus 로고
    • Mechanism underlying counterregulation of autoimmune diabetes by IL-4
    • Mueller, R. et al. (1997) Mechanism underlying counterregulation of autoimmune diabetes by IL-4. Immunity 7, 411-418
    • (1997) Immunity , vol.7 , pp. 411-418
    • Mueller, R.1
  • 72
    • 0035871844 scopus 로고    scopus 로고
    • + T cells
    • + T cells. J. Immunol. 166, 5250-5257
    • (2001) J. Immunol. , vol.166 , pp. 5250-5257
    • Bonini, C.1
  • 73
    • 0032738601 scopus 로고    scopus 로고
    • DNA immunization to prevent autoimmune diabetes
    • Coon, B. et al. (1999) DNA immunization to prevent autoimmune diabetes. J. Clin. Invest. 104, 189-194
    • (1999) J. Clin. Invest. , vol.104 , pp. 189-194
    • Coon, B.1
  • 74
    • 0036146319 scopus 로고    scopus 로고
    • Endogenous expression levels of autoantigens influence success or failure of DNA immunizations to prevent type 1 diabetes: Addition of IL-4 increases safety
    • Wolfe, T. et al. (2002) Endogenous expression levels of autoantigens influence success or failure of DNA immunizations to prevent type 1 diabetes: addition of IL-4 increases safety. Eur. J. Immunol. 32, 113-121
    • (2002) Eur. J. Immunol. , vol.32 , pp. 113-121
    • Wolfe, T.1
  • 75
    • 0034897403 scopus 로고    scopus 로고
    • Combination of gene delivery and DNA vaccination to protect from and reverse Th1 autoimmune disease via deviation to the Th2 pathway
    • Garren, H. et al. (2001) Combination of gene delivery and DNA vaccination to protect from and reverse Th1 autoimmune disease via deviation to the Th2 pathway. Immunity 15, 15-22
    • (2001) Immunity , vol.15 , pp. 15-22
    • Garren, H.1
  • 76
    • 0035253510 scopus 로고    scopus 로고
    • Antigen-specific mediated suppression of beta cell autoimmunity by plasmid DNA vaccination
    • Tisch, R. et al. (2001) Antigen-specific mediated suppression of beta cell autoimmunity by plasmid DNA vaccination. J. Immunol. 166, 2122-2132
    • (2001) J. Immunol. , vol.166 , pp. 2122-2132
    • Tisch, R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.