Gene transfer in skeletal muscle by systemic injection of DODAC lipopolyplexes

Neurological Sciences

Volumn 21, Issue 3 SUPPL., 2000, Pages

  Pampinella, F ^a   Pozzobon, M ^a   Zanetti, E ^a   Gamba, P G ^a   McLachlan, I ^b   Cantini, M ^a   Vitiello, L ^a   Gamba, P O ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b Inex Pharmaceuticals   (Canada)

Author keywords

Gene therapy; Lipopolyplexes; Muscle; Systemic administration

Indexed keywords

DIMETHYLDIOCTADECYLAMMONIUM; DNA; LIPOSOME; QUATERNARY AMMONIUM DERIVATIVE; SURFACTANT;

ANIMAL; ARTICLE; CHEMICALLY INDUCED DISORDER; DRUG ADMINISTRATION ROUTE; DRUG EFFECT; GENE THERAPY; GENE VECTOR; GENETICS; MALE; METABOLISM; METHODOLOGY; MUSCLE DISEASE; PATHOPHYSIOLOGY; PHYSIOLOGY; PLASMID; RAT; REGENERATION; REPORTER GENE; SKELETAL MUSCLE; SYNTHESIS; TREATMENT OUTCOME; WISTAR RAT;

ANIMALS; DNA; DRUG ADMINISTRATION ROUTES; GENE THERAPY; GENES, REPORTER; GENETIC VECTORS; LIPOSOMES; MALE; MUSCLE, SKELETAL; MUSCULAR DISEASES; PLASMIDS; QUATERNARY AMMONIUM COMPOUNDS; RATS; RATS, WISTAR; REGENERATION; SURFACE-ACTIVE AGENTS; TREATMENT OUTCOME;

EID: 0041914127     PISSN: 15901874     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Smith J, Zhang Y, Niven R (1997) Towards development of a non-viral gene therapeutic. Adv Drug Del Rev 26:135-150
2. Gill DR, Southern KW, Mofford KA, Seddon T, Huang L et al (1997) A placebo-controlled study of liposome-mediated gene transfer to the nasal epithelium of patients with cystic fibrosis. Gene Ther 4:199-209
3. Nabel GJ, Gordon D, Bishop DK, Nickoloff BJ, Yang ZY et al (1996) Immune response in human melanoma after transfer of an allogeneic class I major histocompatibility complex gene with DNA-liposome complexes. Proc Natl Acad Sci USA93:15388-15393
4. Alton EW, Stern M, Parley R, Jaffe A, Chadwick SL et al (1999) Cationic lipid-mediated CFTR gene transfer to the lungs and nose of patients with cystic fibrosis: a double-blind placebo-controlled trial. Lancet 353:947-954
5. Feigner PL (1999) Progress in gene delivery research and development. In: Huang L, Hung MC, Wagner E (eds) Nonviral vectors for gene therapy. Academic, San Diego, pp 26-36
6. Hofland HE, Nagy D, Liu JJ, Spratt K, Lee YLet al (1997) In vivo gene transfer by intravenous administration of stable cationic lipid/DNA complex. Pharm Res 14:742-749
7. Vitiello L, Bockhold K, Joshi PB, Worten RG (1998) Transfection of cultured myoblasts in high serum concentration with DODACDOPE liposomes. Gene Ther 5(10):1306-1313
8. Mussini I, Favaro G, Carraro U (1987) Maturation, dystrophic changes and the continuous production of fibers in skeletal muscle regenerating in the absence of nerve. J Neuropathol ExpNeurol 46:315-331
9. Grounds M, Yablonka-Reuveni Z (1993) Molecular and cellular biology of skeletal muscle regeneration. Mol Cell Biol Hum Dis Ser 3:210-256
10. Budker V, Zhang G, Danko I, Williams P, Wolff J (1998) The efficient expression of intravascularly delivered DNA in rat muscle. Gene Ther 5:272-276