Expanding the family of phospholane-based ligands: 1,2-bis(2,5-diphenylphospholano)ethane

Organic Letters

Volumn 5, Issue 8, 2003, Pages 1273-1275

  Pilkington, Christopher J ^a   Zanotti Gerosa, Antonio ^a  

^a DOW CHEMICAL COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 BIS(2,5 DIPHENYLPHOSPHOLANO)ETHANE; ALKANE DERIVATIVE; PHOSPHORUS DERIVATIVE; RHODIUM; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; HYDROGENATION; STEREOCHEMISTRY; SYNTHESIS;

EID: 0041911357     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol0341952     Document Type: Article

References (23)

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16. 2).
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18. Chialpak AD-H (250 x 4.6 mm), heptane/EtOH 80/20, 1 mL/min, 25°C, detection by UV at 210 nm: 9.5 min (S,S), 15.2 min (R,R), 22.9 min (meso); >98% ee.
19. Under the same conditions Me-DuPHOS produced an ee of 98%, while Et-DuPHOS gave an ee > 99%.
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21. 4 92% ee; see ref 14 for further details.
22. Reactions were performed in a thermostated 300 mL reaction vessel with 50 g of substrate in MeOH at 25°C under 10 bar hydrogen pressure. The substrate was used as bought from Acros, 97% purity. S/C denotes molar substrate-to-catalyst ratio. Conversion and enantiomeric excess were determined by chiral GC.
23. Reactions were performed in a 50 mL reaction vessel with 0.8-1 M solutions of substrate in MeOH at 25°C under 10 bar hydrogen pressure. S/C denotes molar substrate-to-catalyst ratio. Conversion and enantiomeric excess were determined by chiral GC or chiral HPLC.