Design and synthesis of a novel family of triazine-based inhibitors of sorbitol dehydrogenase with oral activity: 1-{4-[3R,5S-dimethyl-4-(4-methyl-[1,3,5]triazin-2-yl)-piperazin-1-yl]-[1,3,5] triazin-2-yl}-(R) ethanol

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 19, 2003, Pages 4179-4188

  Mylari, Banavara L ^a,b   Withbroe, Gregory J ^a   Beebe, David A ^a   Brackett, Nathaniel S ^a   Conn, Edward L ^a   Coutcher, James B ^a   Oates, Peter J ^a   Zembrowski, William J ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [4 [3,5 DIMETHYL 4 (4 PHENYL[1,3,5]TRIAZIN 2 YL)PIPERAZIN 1 YL][1,3,5]TRIAZIN 2 YL]ETHANOL; 1 [4 [4 (4 CYCLOPROPYL[1,3,5]TRIAZIN 2 YL)DIMETHYLPIPERAZIN 1 YL][1,3,5]TRIAZIN 2 YL]ETHANOL; 1 [4 [DIMETHYL 4 (4 METHYL[1,3,5]TRIAZIN 2 YL)PIPERAZIN 1 YL][1,3,5]TRIAZIN 2 YL]ETHANOL; 2 HYDROXYETHYLPYRIDINE; 2 HYDROXYETHYLTRIAZINE; 4 (4 HYDROXYMETHYL[1,3,5]TRIAZIN 2 YL)PIPERAZINE 1 SULFONIC ACID DIMETHYLAMIDE; 4 [(2 HYDROXYETHYL)PYRIDIN 4 YL]PIPERAZINE 1 SULFONIC ACID DIMETHYLAMIDE; DIMETHYLAMINOACETIC ACID 1 [4 [DIMETHYL 4 (4 METHYL[1,3,5]TRIAZIN 2 YL)PIPERAZIN 1 YL][1,3,5]TRIAZIN 2 YL]ETHYL ESTER; FRUCTOSE; IDITOL DEHYDROGENASE; LIGAND; PIPERAZINE DERIVATIVE; PYRIDINE DERIVATIVE; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG; ZINC;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CATALYSIS; CHRONIC DISEASE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG ACTIVITY; DRUG BINDING; DRUG DESIGN; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; INHIBITION KINETICS; MALE; NONHUMAN; PROTEIN BINDING; RAT; SCIATIC NERVE; SUBSTITUTION REACTION;

EID: 0041888262     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(03)00490-5     Document Type: Article

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