C-reactive protein and gestational diabetes: The central role of maternal obesity

Journal of Clinical Endocrinology and Metabolism

Volumn 88, Issue 8, 2003, Pages 3507-3512

  Retnakaran, Ravi ^a   Hanley, Anthony J G ^a,b   Raif, Nuryt ^b   Connelly, Philip W ^c   Sermer, Mathew ^b   Zinman, Bernard ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b MOUNT SINAI HOSPITAL   (Canada)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; GLUCOSE; INSULIN; INTERLEUKIN 6;

ACUTE PHASE RESPONSE; ADULT; ARTICLE; BODY MASS; BODY WEIGHT DISORDER; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; DIET RESTRICTION; DISEASE MARKER; FEMALE; GLUCOSE METABOLISM; HIGH RISK PATIENT; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INCIDENCE; INFLAMMATION; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MATERNAL WELFARE; METABOLIC DISORDER; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PATHOPHYSIOLOGY; PREDICTION; PREGNANCY DIABETES MELLITUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; STATISTICAL ANALYSIS; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

ADULT; BLOOD GLUCOSE; C-REACTIVE PROTEIN; DIABETES, GESTATIONAL; ETHNIC GROUPS; FEMALE; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN; INSULIN RESISTANCE; MULTIVARIATE ANALYSIS; OBESITY; PREGNANCY; RISK FACTORS; SMOKING;

EID: 0041883484     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2003-030186     Document Type: Article

References (30)

1. Pickup JC, Crook MA 1998 Is type 2 DM a disease of the innate immune system? Diabetologia 41:1241-1248
2. Pickup JC, Mattock MB, Chusney GD, Burt D 1997 NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X. Diabetologia 40:1286-1292
3. Festa A, D'Agostino Jr R, Howard G, Mykkanen L, Tracy RP, Haffner SM 2000 Chronic subclinical inflammation as part of the insulin resistance syndrome. Circulation 102:42-47
4. Yudkin JS, Stehouwer CDA, Emeis JJ, Coppack SW 1999 C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction. Arterioscler Thromb Vasc Biol 19:972-978
5. Ross R 1999 Atherosclerosis: an inflammatory disease. N Engl J Med 340:115-126
6. Lagrand WK, Visser CA, Hermens WT, Niessen HWM, Verheught FWA, Wolbink G-J, Hack CE 1999 C-reactive protein as a cardiovascular risk factor: more than an epiphenomenon? Circulation 100:96-102
7. Stem MP 1995 Diabetes and cardiovascular disease: the "common soil" hypothesis. Diabetes 44:369-374
8. Ridker PM, Cushman M, Stampfer MJ, Tracy RP, Hennekens CH 1997 Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med 336:973-979
9. Koenig W, Sund M, Frolich M, Fischer HG, Lowel H, Doring A, Hutchinson WL, Pepys MB 1999 C-Reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men: results from the MONICA (Monitoring Trends and Determinants in Cardiovascular Disease) Augsburg Cohort Study. Circulation 99:237-242
10. Ridker PM, Hennekens CH, Buring JE, Rifai N 2000 C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med 342:836-843
11. Huber K, Christ G, Wojta J, Gulba D 2001 Plasminogen activator inhibitor type-1 in cardiovascular disease status report 2001. Thromb Res 103:S7-S19
12. Pradhan AD, Manson JE, Rifai N, Buring J, Ridker PM 2001 C-reactive protein, interleukin 6 and risk of developing type 2 diabetes mellitus. JAMA 286:327-334
13. Freeman DJ, Norrie J, Caslake MJ, Gaw A, Ford I, Lowe G, O'Reilly D, Packard C, Sattar N 2002 C-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study. Diabetes 51:1596-1600
14. Barzilay JI, Abraham L, Heckbert SR, Cushman M, Kuller LH, Resnick HE, Tracy RP 2001 The relation of markers of inflammation to the development of glucose disorders in the elderly: the Cardiovascular Health Study. Diabetes 50:2384-2389
15. Festa A, D'Agostino Jr R, Tracy RP, Haffner SM 2002 Elevated levels of acute-phase proteins and plasminogen activator inhibitor-1 predict the development of type 2 diabetes. The Insulin Resistance Atherosclerosis Study. Diabetes 51:1131-1137
16. Buchanan TA 2001 Pancreatic B-cell defects in gestational diabetes: implications for the pathogenesis and prevention of type 2 diabetes. J Clin Endocrinol Metab 86:989-993
17. Kjos SL, Buchanan TA 1999 Gestational diabetes. N Engl J Med 341:1749-1756
18. Clark Jr CM, Qiu C, Amerman B, Porter B, Fineberg N, Aldasouqi S, Golichowski A 1997 Gestational diabetes: should it be added to the syndrome of insulin resistance ? Diabetes Care 20:867-871
19. Sriharan M, Reichelt AJ, Opperman ML, Duncan BB, Mengue SS, Crook MA, Schmidt MI 2002 Total sialic acid and associated elements of the metabolic syndrome in women with and without previous gestational diabetes. Diabetes Care 25:1331-1335
20. Rifai N, Tracy RP, Ridker PM 1999 Clinical efficacy of an automated high-sensitivity C-reactive protein assay. Clin Chem 45:2136-2141
21. National Diabetes Data Group 1979 Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes 28:1039-1057
22. Ramsay JE, Ferrell WR, Crawford L, Wallace MA, Greer IA, Sattar N 2002 Maternal obesity is associated with dysregulation of metabolic, vascular, and inflammatory pathways. J Clin Endocrinol Metab 87:4231-4237
23. Ford ES 1999 Body mass index, diabetes and C-reactive protein among U.S. adults. Diabetes Care 22:1971-1977
24. Visser M, Bouter LM, McQuillan GM, Wener MH, Harris TB 1999 Elevated C-reactive protein levels in overweight and obese adults. JAMA 282:2131-2135
25. Festa A, D'Agostino Jr B, Williams K, Karter AJ, Mayer-Davis EJ, Tracy RP, Haffner SM 2001 The relation of body fat mass and distribution to markers of chronic inflammation. Int J Obes 25:1407-1415
26. Redman CW, Sacks GP, Sargent IL 1999 Pre-eclampsia: an excessive maternal inflammatory response to pregnancy. Am J Obstet Gynecol 180:490-506
27. Wolf M, Kettyle E, Sandler L, Ecker JL, Roberts J, Thadhani R 2001 Obesity and pre-eclampsia: the potential role of inflammation. Obstet Gynecol 98:757-762
28. Kirwan JP, Hauguel-De Mouzon S, Lepercq J, Challier J, Huston-Presley L, Friedman JC, Kalhan SC, Catalano PM 2002 TNF-α is a predictor of insulin resistance in human pregnancy. Diabetes 51:2207-2213
29. Hotamisligil GS, Shargill NS, Spiegelman BM 1993 Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259:87-91
30. Stephens JM, Butts MD, Pekala PH 1992 Regulation of transcription factor mRNA accumulation during 3T3-L1 preadipocyte differentiation by tumor necrosis factor-alpha. J Mol Endocrinol 9:61-72