Two-locus linkage analysis applied to putative quantitative trait loci for lipoprotein(a) levels

Twin Research

Volumn 6, Issue 4, 2003, Pages 322-324

  Beekman, Marian ^a   Heijmans, Bastiaan T ^a   Martin, Nicholas G ^b   Whitfield, John B ^c   Pedersen, Nancy L ^d   DeFaire, Ulf ^d   Snieder, Harold ^e,f   Lakenberg, Nico ^a   De Knijff, Peter ^a   Frants, Rune R ^a   Van Ommen, Gert Jan B ^a   Kluft, Cornelis ^g   Vogler, George P ^h   Slagboom, P Eline ^a   Boomsma, Dorret I ⁱ  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^c ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^d KAROLINSKA INSTITUTE   (Sweden)

^e ST THOMAS HOSPITAL   (United Kingdom)

^f MEDICAL COLLEGE OF GEORGIA   (United States)

^g TNO   (Netherlands)

^h PENNSYLVANIA STATE UNIVERSITY   (United States)

ⁱ VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

LIPOPROTEIN A;

ADOLESCENT; ADULT; ARTICLE; CARDIOVASCULAR DISEASE; CHROMOSOME 1; CHROMOSOME 6; DIZYGOTIC TWINS; GENETIC LINKAGE; HEALTH STATUS; HERITABILITY; HUMAN; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MONOZYGOTIC TWINS; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; TWINS;

ADOLESCENT; CHROMOSOMES, HUMAN, PAIR 1; CHROMOSOMES, HUMAN, PAIR 6; HUMANS; LINKAGE (GENETICS); LIPOPROTEINS; QUANTITATIVE TRAIT LOCI; TWINS; TWINS, DIZYGOTIC; TWINS, MONOZYGOTIC;

EID: 0041877724     PISSN: 13690523     EISSN: None     Source Type: Journal    
DOI: 10.1375/136905203322296692     Document Type: Article

References (13)

1. Beekman, M., Heijmans, B. T., Martin, N. G., Pedersen, N. L., Whitfield, J. B., DeFaire, U., et al. (2002). Heritabilities of apolipoprotein and lipid levels in three countries. Twin Research, 5(2), 87-97.
2. Beekman, M., Lakenberg, N., Cherny, S. S., de Knijff, P., Kluft, C. C., van Ommen, G. J., et al. (2001). A powerful and rapid approach to human genome scanning using small quantities of genomic DNA. Genetical Research, 77(2), 129-134.
3. Boerwinkle, E., Leffert, C. C., Lin, J., Lackner, C., Chiesa, G., & Hobbs, H. H. (1992). Apolipoprotein(a) gene accounts for greater than 90% of the variation in plasma lipoprotein(a) concentrations. Journal of Clinical Investigation, 90(1), 52-60.
4. Boomsma, D. I., Kaptein, A., Kempen, H. J., Gevers, L. J., & Princen, H. M. (1993). Lipoprotein(a): Relation to other risk factors and genetic heritability. Results from a Dutch parent-twin study. Atherosclerosis, 99(1), 23-33.
5. Broeckel, U., Hengstenberg, C., Mayer, B., Holmer, S., Martin, L. J., Comuzzie, A. G., et al. (2002). A comprehensive linkage analysis for myocardial infarction and its related risk factors. Nature Genetics, 30(2), 210-214.
6. Danesh, J., Collins, R., & Peto, R. (2000). Lipoprotein(a) and coronary heart disease. Meta-analysis of prospective studies. Circulation, 102(10), 1082-1085.
7. DeMeester, C. A., Bu, X., Gray, R. J., Lusis, A. J., & Rotter, J. I. (1995). Genetic variation in lipoprotein (a) levels in families enriched for coronary artery disease is determined almost entirely by the apolipoprotein (a) gene locus. American Journal of Human Genetics, 56(1), 287-293.
8. Göring, H. H., Terwilliger, J. D., & Blangero, J. (2001). Large upward bias in estimation of locus-specific effects from genomewide scans. American Journal of Human Genetics, 69(6), 1357-1369.
9. Kruglyak, L., Daly, M. J., Reeve-Daly, M. P., & Lander, E. S. (1996). Parametric and nonparametric linkage analysis: A unified multipoint approach. American Journal of Human Genetics, 58(6), 1347-1363.
10. Neale, M. C., Boker, S. M., Xie, G., & Maes, H. H. (1999). Mx: Statistical modeling (5th ed.). Richmond, VA: VCU, Department of Psychiatry.
11. Rainwater, D. L. (1996). Lp(a) concentrations are related to plasma lipid concentrations. Atherosclerosis, 127(1), 13-18.
12. Sham, P. C., Cherny, S. S., Purcell, S., & Hewitt, J. K. (2000). Power of linkage versus association analysis of quantitative traits, by use of variance-components models, for sibship data. American Journal of Human Genetics, 66(5), 1616-1630.
13. Snieder, H., van Doornen, L. J., & Boomsma, D. I. (1997). The age dependency of gene expression for plasma lipids, lipoproteins, and apolipoproteins. American Journal of Human Genetics, 60(3), 638-650.