Early cognitive decline is associated with prion protein codon 129 polymorphism [1]

Annals of Neurology

Volumn 54, Issue 2, 2003, Pages 275-276

  Croes, Esther A ^a   Dermaut, Bart ^b   Houwing Duistermaat, Jeanine J ^a   Van den Broeck, Marleen ^b   Cruts, Marc ^b   Breteler, Monique M B ^a   Hofman, Albert ^a   Van Broeckhoven, Christine ^b   Van Duijn, Cornelia M ^a,b  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

METHIONINE; PRION PROTEIN; VALINE;

ADULT; AGED; BELGIUM; CLINICAL FEATURE; CODON; CODON 129; COGNITIVE DEFECT; FOLLOW UP; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HETEROZYGOTE; HUMAN; LETTER; MAJOR CLINICAL STUDY; MINI MENTAL STATE EXAMINATION; POPULATION RESEARCH; PRIORITY JOURNAL;

AGE OF ONSET; AGED; AGED, 80 AND OVER; ALLELES; CODON; COGNITION DISORDERS; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; POLYMORPHISM, GENETIC; PRIONS;

EID: 0041843758     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/ana.10658     Document Type: Letter

References (5)

1. Alperovitch A, Zerr I, Pocchiari M, et al. Codon 129 prion protein genotype and sporadic Creutzfeldt-Jakob disease. Lancet 1999;353:1673-1674.
2. Casadei VM, Ferri C, Calabrese E, et al. Prion protein gene polymorphism and Alzheimer's disease: one modulatory trait of cognitive decline? J Neurol Neurosurg Psychiatry 2001;71:279-280.
3. Hofman A, Grobbee DE, de Jong PT, van den Ouweland FA. Determinants of disease and disability in the elderly: the Rotterdam Elderly Study. Eur J Epidemiol 1991;7:403-422.
4. Berr C, Richard F, Dufouil C, et al. Polymorphism of the prion protein is associated with cognitive impairment in the elderly: the EVA study. Neurology 1998;51:734-737.
5. Dermaut B, Croes EA, Rademakers R, et al. PRNP Val129 homozygosity increases risk for early-onset Alzheimer's disease. Ann Neurol 2003;53:409-412.