Efficacy of pentasaccharide on a prethrombosis model based on a calibrated stasis by the increase in up-stream venous pressure

Blood Coagulation and Fibrinolysis

Volumn 14, Issue 6, 2003, Pages 587-591

  Pottier, Pierre ^a   Planchon, B ^a   Truchaud, F ^a   Leftheriotis, G ^b   Herbert, J M ^c   Bressollette, L ^d   Passuti, N ^a  

^a HÔTEL DIEU   (France)

^b ANGERS UNIVERSITY HOSPITAL   (France)

^c SANOFI   (France)

^d SERVICE DE RHUMATOLOGIE   (France)

Author keywords

Animal; Central venous pressure; Disease models; Pentasaccharide; Thromboembolism; Thromboplastin

Indexed keywords

FONDAPARINUX; PENTASACCHARIDE; THROMBOPLASTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALIBRATION; CONTROLLED STUDY; DRUG EFFICACY; HEMOSTASIS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STATISTICAL ANALYSIS; THROMBOGENESIS; THROMBOSIS; UPREGULATION; VENOUS PRESSURE;

ANIMALS; ANTITHROMBIN III; BLOOD PRESSURE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HEMOSTASIS; MALE; PEPTIDE HYDROLASES; POLYSACCHARIDES; RATS; RATS, SPRAGUE-DAWLEY; THROMBOPHILIA; THROMBOPLASTIN; THROMBOSIS; TREATMENT OUTCOME;

EID: 0041831051     PISSN: 09575235     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001721-200309000-00011     Document Type: Article

References (16)

1. Levi M, Dörffler-Melly J, Johnson G, Drouet L, Badimon L. Usefulness and limitations of animal models of venous thrombosis. Thromb Haemost 2001; 86:1331-1333.
2. Pottier P, Planchon B, Truchaud F, Leftheriotis G, Herbert JM, Bressollette L, et al. Development of an experimental model of prethrombosis in rats based on Wessler's principle using a calibrated venous stasis. Blood Coagul Fibrinolysis 2003; 14:3-9.
3. Vogel GMT, Meuleman DG, Bourgondiën FGM, Hobbelen PMJ. Comparison of two experimental thrombosis models in rats. Effects of four glycosaminoglycans. Thromb Res 1989; 54:399-410.
4. Thomas DP, Merton RE, Gray E, Barrowcliffe TW. The relative antithrombotic effectiveness of heparin, a low molecular weight heparin, and a pentasaccharide fragment in an animal model. Thromb Haemost 1989; 61:204-207.
5. Herbert JM, Bernat A, Maffrand JP. Importance of platelets in experimental venous thrombosis in the rat. Blood 1992; 9:2281-2286.
6. Fredrich M, Zierz R, Morser J, Wydro R, Witt W. A new animal model of venous thrombosis in rats with low flow conditions in the venous blood stream. Blood Coagul Fibrinolysis 1994; 5:243-248.
7. Eriksson BI, Bauer KA, Lassen MR, Turpie AG. Fondaparinux compared with enoxaparin for the prevention of venous thromboembolism after hipfracture surgery. N Engl J Med 2001; 345:1298-1304.
8. Turpie AG, Bauer KA, Eriksson BI, Lassen MR. Postoperative fondaparinux versus postoperative enoxaparin for prevention of venous thromboembolism after elective hip-replacement surgery: a randomised double-blind trial. Lancet 2002; 359:1721-1726.
9. Ravanat C, Freund M, Dol F, Cadroy Y, Roussi J, Incardona F, et al. Cross-reactivity of human molecular markers for detection of prethrombotic states in various animal species. Blood Coagul Fibrinolysis 1995; 6:446-455.
10. Herault JP, Donat F, Barzu T, Crepon B, Bernat A, Lormeau JC, Herbert JM. Pharmacokinetic study of three synthetic AT-binding pentasaccharides in various animal species - extrapolation to humans. Blood Coagul Fibrinolysis 1997; 8:161-167.
11. Herbert JM, Herault JP, Bernat A, Van Amsterdam RGM, Lormeau JC, Petitou M, Meuleman DG. Biochemical and pharmacological properties of SANORG 32701. Comparison with the 'synthetic pentasaccharide' (SR90107/ORG 31540) and standard heparin. Circ Res 1996; 79:590-600.
12. Herbert JM, Petitou M, Lormeau JC, Cariou R, Necciari J, Magnani HN, et al. SR 90107A/Org 31540, a novel anti-factor Xa antithrombotic agent. Cardiovasc Drugs Rev 1997; 15:1-26.
13. Walenga JM, Fareed J, Petitou M, Samama M, Lormeau JC, Choay J. Intravenous antithrombotic activity of a synthetic heparin pentasaccharide in a human serum induced stasis thrombosis model. Thromb Res 1986; 43:243-248.
14. Walenga JM, Petitou M, Lormeau JC, Samama M, Fareed J, Choay J. Antithrombotic activity of a synthetic heparin pentasaccharide in a rabbit stasis thrombosis model using different thrombogenic challenges. Thromb Res 1987; 46:187-198.
15. Mysliwiec M, Villa S, Kronblatt L, De Gaetano G, Donati MB. Decreased plaminogen activator but normal prostacyclin activity in rat veins during development of experimental thrombosis. Thromb Res 1980; 18:159-165.
16. Stenberg B, Bylock A, Risberg B. Effect of venous stasis on vessel wall fibrinolysis. Thromb Haemost 1984; 51:240-242.