Stimulation of degenerative changes in the intervertebral disc through load in an animal model;Stimulierung degenerativer veränderungen der bandscheibe durch axiale belastung - Radiologische, histologische und biomechanische untersuchungen an einem tiermodell

Zeitschrift fur Orthopadie und Ihre Grenzgebiete

Volumn 141, Issue 4, 2003, Pages 412-417

  Unglaub, F ^a   Lorenz, H ^a   Nerlich, A ^c   Richter, W ^a   Kroeber, Markus W ^a,b  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NONE

Author keywords

Animal model; Apoptosis; Degeneration of the intervertebral disc; Histology; Radiology

Indexed keywords

ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BIOMECHANICS; CELL DEATH; COMPRESSION; CONTROLLED STUDY; DISEASE MODEL; FEASIBILITY STUDY; HISTOLOGY; INSTRUMENTATION; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK DEGENERATION; INTERVERTEBRAL DISK HERNIA; LUMBAR VERTEBRA; MECHANICAL STRESS; METHODOLOGY; NONHUMAN; PATHOLOGY; PATHOPHYSIOLOGY; RABBIT; RADIOGRAPHY; SIMULATION; SPINE RADIOGRAPHY; STIMULATION; TISSUE ENGINEERING; WEIGHT BEARING;

ANIMALS; CELL DEATH; DISEASE MODELS, ANIMAL; FEASIBILITY STUDIES; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK DISPLACEMENT; LUMBAR VERTEBRAE; PHYSICAL STIMULATION; RABBITS; STRESS, MECHANICAL; WEIGHT-BEARING;

EID: 0041829336     PISSN: 00443220     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2003-41567     Document Type: Article

References (26)

1. Guiot B, Fessler R. Molecular biology of degenerative disc disease. Neurosurgery 2000; 47 (5): 1034-1039
2. Hansis M. Stand der Erkenntnisse zur Begutachtung der BK 2108-2110. Unfallchirurg 1998; 101: 799-801
3. Lotz J, Colliou O, Chin J, Duncan N, Liebenberg E. Compression-induced degeneration of the intervertebral disc: an in vivo mouse model and finite-element study. Spine 1998; 23 (23): 2493-2506
4. Hutton WC, Ganey TM, Elmer WA, Kozlowska E, Ugbo JL, Doh ES, Whitesides TE. Does long-term compressive loading on the intervertebral disc cause degeneration? Spine 2000; 25 (23): 2993-3004
5. Iatridis JC, Mente PL, Stokes IA, Aronsson DD, Alini M. Compression-induced changes in intervertebral disc properties in a rat tail model. Spine 1999; 24 (10): 996-1002
6. Taylor W, Taylor T. Sulphated acid mucopolysaccharide metabolism in the rabbit intervertebral disc. Journal of Bone and Joint Surgery 1970; 52B: 371-383
7. Peacock A. Observations on postnatal structure of the intervertebral disc in man. J Anat 1952; 86: 162-176
8. Cornah M, Meachim G, Parry E. Banded structures in the matrix of human and rabbit nucleus pulposus. J Anat 1970; 107 (2): 351-362
9. Inoue H. Three dimensional observations of collagen framework of intervertebral discs in rats, dogs and humans. Archivum histologicum japonicum 1973; 36: 39-56
10. Nerlich AG, Schleichert E, Boos N. Immunohistologic markers for age-related changes of human lumbar intervertebral discs. Spine 1997; 22 (24): 2781-2795
11. Chen CT, Burton-Wurster N, Borden C, Hueffer K, Bloom SE, Lust G. Chondrocyte necrosis and apoptosis in impact damaged articular cartilage. J Orthop Res 2001; 19 (4): 703-711
12. Thompson J, Pearce R, Schechter M, Adams M, Tsang I, Bishop P. Preliminary evaluation of a scheme for grading the gross morphology of the human intervertebral disc. Spine 1990; 15 (5): 411-415
13. Takaishi H, Nemoto O, Shiota M, Kikuchi T, Yamada H, Yamagishi M, Yabe Y. Type 11 collagen gene expression is transiently upregulated in experimentally induced degeneration of rabbit intervertebral disc. J Orthop Res 1997; 15 (4): 528-538
14. Lipson SJ, Muir H. Proteoglycans in experimental intervertebral disc degeneration. Spine 1981; 6: 194-210
15. Higuchi M, Abe K, Kaneda K. Changes in the nucleus pulposus of the intervertebral disc in bipedal mice. Clin Orthop 1983; 175: 251-257
16. Parkkinen JJ, Lammi MJ, Helminen HJ, Tammi M. Local stimulation of proteoglycan synthesis in articular cartilage explants by dynamic compression in vitro. J Orthop Res 1992; 10: 610-620
17. Larsson T, Aspden RM, Heinegard D. Effects of biomechanical load on cartilage matrix biosynthesis in vitro. Matrix 1991; 11: 388-394
18. Lee DA, Bader DL. Compressive strains at physiological frequencies influence the metabolism of chondrocytes seeded in agarose. J Orthop Res 1997; 15: 181-188
19. Hodler J. Degenerative Veränderungen der Halswirbelsäule. Orthopäde 1996; 25: 512-518
20. Hartwig E, Hoellen I, Liener U, Kramer M, Wickstroem M, Kinzl L. Berufserkrankung 2108. Kernspintomographische Degenerationsmuster der LWS von Patienten mit unterschiedlicher wirbelsäulenbelastender Tätigkeit. Unfallchirurg 1997; 100: 888-894
21. Argoubi M, Shirazi-Adl A. Poroelastic creep response of a lumbar motion segment in compression. J Biomech 1996; 29: 1131-1139
22. Götz W, Barnert S, Bertagnoli R, Miosge N, Kresse H, Herken R. Immunhistochemical localization of the small proteoglycans in human intervertebral discs. Cell Tissue Res 1997; 289 (1): 185-190
23. Tornusciolo DR, Schmidt RE, Roth Ka. Simultaneous detection of TDT-mediated dUTP-biotin nick end-labeling (TUNEL)-positive cells and multiple immunohistochemical markers in single tissue sections. Biotechniques 1995; 19 (5): 800-805
24. Lotz J, Chin J. Intervertebral disc cell death is dependent on the magnitude and duration of spinal loading. Spine 2000; 25 (12): 1477-1481
25. Mimura M, Panjabi MM, Oxland TR, Crisco JJ, Yamamoto I, Vasavada A. Disc degeneration affects the multidirectional flexibility of the lumbar spine. Spine 1994; 19 (12): 1371-1380
26. Adams MA, Dolan P, Hutton WC, Porter RW. Diurnal changes in spinal mechanics and their clinical significance. J Bone Joint Surg [Br] 1990; 72: 266-270