Codonopsis pilosula (Franch) Nannf total alkaloids potentiate neurite outgrowth induced by nerve growth factor in PC12 cells

Acta Pharmacologica Sinica

Volumn 24, Issue 9, 2003, Pages 913-917+950

  Liu, Jian Hui ^a   Bao, Yong Ming ^a   Song, Ji Jun ^a   An, Li Jia ^a  

^a DALIAN UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

Alkaloids; Codonopsis; Mitogen activated protein kinases; Nerve growth factors; Neurites

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ALKALOID; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; NERVE GROWTH FACTOR; PROTEIN KINASE;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STRAIN; CODONOPSIS; CODONOPSIS PILOSULA; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ASSAY; NERVE CELL DIFFERENTIATION; NERVE FIBER GROWTH; NONHUMAN; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

ALKALOIDS; ANIMALS; CELL DIFFERENTIATION; CELL DIVISION; CODONOPSIS; DRUG SYNERGISM; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NERVE GROWTH FACTOR; NEURITES; NEURONS; PC12 CELLS; PHOSPHORYLATION; PLANTS, MEDICINAL; RATS;

EID: 0041817679     PISSN: 16714083     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Deshmukh M, Johnson EM. Programmed cell death in neurons: focus on the pathway of nerve growth factor deprivation-induced death of sympathetic neurons. Mol Pharmacol 1997; 51: 897-906.
2. Baker PA, Shooter EM. Disruption of NGF binding to the low affinity neurotrophin receptor p75 LNTR reduces NGF binding to trkA on PC12 cells. Neuron 1994; 13: 203-15.
3. Swain C, Harper S, Pollack S, Smith R, Hefti F. Neurotrophic factor mimetics. In: Hefti F, editor. Handbook of experimental pharmacology; v 134. Berlin: Springer; 1998. p281-300.
4. Jin ZL, Wen J, Li SF. Antiaging effect of shenqi mixture tonic. Chin Trad Herb Drugs 1996; 27: 90-2.
5. Pan SY. Circadian effects of scopolamine on memory, exploratory behavior, and muscarinic receptors in mouse brain. Acta Pharmacol Sin 1992; 13: 323-6.
6. Weikert T, Rathjen FG, Layer PG. Use of the ELISA to G4 antigen to quantitate neurite outgrowth in the chick both in vivo and in vitro. J Neurochem 1994; 62: 1570-7.
7. Sano M, Kohno M, Iwanaga M. The activation and translation of extracellular signal-regulated kinases (ERK-1 and ERK-2) appear not to be required for elongation of neurites in PC12D cells. Brain Res 1995; 688: 213-8.
8. Wood KW, Qi H, Arcangelo GD, Armstrong RC, Roberts TM, Halegoua S. The cytoplasmic rat oncogene induces a neuronal phenotype in PC12 cells: a potential role for cellular rat kinase in neuronal growth factor signal conduction. Proc Nat Acad Sci USA 1993; 90: 5016-20.
9. Montaleini RL. The nerve growth factor: thirty-five years later. EMBO J 1987; 6: 1145-54.
10. Futerman AH, Banker GA. The economics of neurite outgrowth - the addition of new membrane to growing axons. Trends Neurosci 1996; 19: 144-9.
11. Greene LA, Aletta JM, Rukenstein A, Greene SH. PC12 pheochromocytoma cells: culture, nerve growth factor treatment, and experimental exploitation. Methods Enzymol 1986; 147: 207-16.
12. Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 1995; 270: 1326-31.
13. Gomez N, Cohen P. Dissection of the protein kinase cascade which nerve growth factor activates MAP kinases. Nature 1991; 353: 170-3.
14. Payne DM, Rossomando AJ, Martino P, Erickson AK, Her JH, Shabanowitz J, et al. Identification of the regulatory phosphorylation site in pp42/44 mitogen-activated protein kinase (MAP kinase). EMBO J 1991; 10: 885-92.
15. Seger R, Krebs EG. The MAPK signaling cascade. FASEB J 1995; 9: 726-35.