HPCE determination of trimebutine maleate in rat plasma and its pharmacokinetics

Yaoxue Xuebao

Volumn 36, Issue 2, 2001, Pages 131-133

  Yu, Li Ning ^a   Li, Fa Mei ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

High performance capillary electrophoresis; Pharmacokinetics; Trimebutine maleate

Indexed keywords

GASTROINTESTINAL AGENT; TRIMEBUTINE;

ANIMAL; AREA UNDER THE CURVE; ARTICLE; BLOOD; CAPILLARY ELECTROPHORESIS; FEMALE; MALE; METHODOLOGY; RAT; WISTAR RAT;

ANIMALS; AREA UNDER CURVE; ELECTROPHORESIS, CAPILLARY; FEMALE; GASTROINTESTINAL AGENTS; MALE; RATS; RATS, WISTAR; TRIMEBUTINE;

EID: 0041808722     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (6)

1. Xue L, Fukuta H, Yamamoto Y, et al. Dual effects of trimebutine on electrical responses of gastric smooth muscles in the rat [J]. Eur J Pharmacol, 1995,294(1):75-81.
2. Yoshikawa M, Endo H, Ohnogi Y, et al. Biological fate of trimebutine maleate (1). Absorption, Distribution and Excretion in rats, mice and dogs [J]. Pharmacometrics, 1982,24(2):289-300.
3. Miura Y, Takeyama S, Yoshikawa M, et al. Metabolism of trimebutine maleate, a gastrointestinal tract motility regulator in rats and mice. Characterization and quantification of metabolites in urine, bile and plasma [J]. J Pharm Soc Jpn, 1988,108(10):989-1000.
4. Yu LN, Li FM. Capillary Electrophoresis for the Determination of Trimebutine Maleate in Capsules [J]. Chin J Pharm Anal (in Chinese), 2001,in press.
5. Braggios, Barnabg RJ, Grossi P, et al. A strategy for validation of bioanalytical methods [J]. J Pharm Biomed Anal, 1996,14(4):375-388.
6. The Pharmacopoeia Commission of PRC. Pharmacopoeia of the People's Republic of China [M]. Part II. Beijing: Chemical Industry Publishing House, 2000. Appendix XIX B.