An experimental study on the pharmacokinetics of 5-fluorouracil regional chemotherapy for pancreatic cancer

Annals of Surgical Oncology

Volumn 10, Issue 5, 2003, Pages 546-550

  Mitsutsuji, Masaaki ^a   Suzuki, Yasuyuki ^a   Iwanaga, Yasuhiro ^a   Fujino, Yasuhiro ^a   Tanioka, Yasuki ^a   Kamigaki, Takashi ^a   Ku, Yonson ^a   Kuroda, Yoshikazu ^a  

^a KOBE UNIVERSITY   (Japan)

Author keywords

5 FU; Intra arterial chemotherapy; Pancreas cancer; Pharmacokinetics

Indexed keywords

FLUOROURACIL; ANTINEOPLASTIC ANTIMETABOLITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY CATHETER; ARTICLE; BLOOD SAMPLING; CANCER CHEMOTHERAPY; CONTROLLED STUDY; DRUG INFUSION; DRUG SAFETY; DRUG TISSUE LEVEL; DUODENUM; FEMALE; GASTRODUODENAL ARTERY; HISTOLOGY; LIVER; MALE; NONHUMAN; PANCREAS; PANCREAS CANCER; SPLEEN ARTERY; ANIMAL; ANIMAL DISEASE; DOG; DRUG EFFECT; EXPERIMENTAL NEOPLASM; INTRAARTERIAL DRUG ADMINISTRATION; PANCREAS TUMOR;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; DOGS; DUODENUM; FEMALE; FLUOROURACIL; INFUSIONS, INTRA-ARTERIAL; LIVER; MALE; NEOPLASMS, EXPERIMENTAL; PANCREATIC NEOPLASMS;

EID: 0041784819     PISSN: 10689265     EISSN: None     Source Type: Journal    
DOI: 10.1245/ASO.2003.07.018     Document Type: Article

References (14)

1. Certer SK, Comis RL. The integration of chemotherapy into a combined modality approach for cancer treatment. Cancer Treat Rev 1975;2:193-214.
2. Zimmerman SE, Smith FP, Schein PS. Chemotherapy of pancreatic carcinoma. Cancer 1981;47:1724-8.
3. Douglass HO. Current approaches to multimodality management of advanced pancreatic cancer. Hepatogastroenterology 1993;40: 433-42.
4. Nicolson M, Webb A, Cunningham D, et al. Cisplatin and protracted venous infusion 5-fluorouracil (CF) - good symptom relief with low toxicity in advanced pancreatic carcinoma. Ann Oncol 1995;6:801-4.
5. Evans TRJ, Lofts FJ, Mansi JL, Gless JP, Dalgleish AG, Knight MJ. A phase II study of continuous-infusion 5-fluorouracil with cisplatin and epirubicin in inoperable pancreatic cancer. Br J Cancer 1996;73:1260-4.
6. Link KH, Gansauge F, Gorich J, Leder GH, Rilinger N, Beger HG. Palliative and adjuvant regional chemotherapy in pancreatic cancer. Eur J Surg Oncol 1997;23:409-14.
7. Aigner KR, Gailhofer S, Kopp S. Regional versus systemic chemotherapy for advanced pancreatic cancer: a randomized study. Hepatogastroenterology 1998;45:1125-9.
8. Lorenz M, Heinrich S, Staib-Sebler E, et al. Regional chemotherapy in the treatment of advanced pancreatic cancer - is it relevant? Eur J Cancer 2000;36:957-65.
9. Ohigashi H, Ishikawa O, Imaoka S, et al. A new method of intra-arterial regional chemotherapy with more selective drug delivery for locally advanced pancreatic cancer. Hepatogastroenterology 1996;43:338-45.
10. Maurer AC, Borner MM, Lauffer J, et al. Celiac axis infusion chemotherapy in advanced nonresectable pancreatic cancer, Int J Pancreatol 1998;23:181-6.
11. Muchmore JH, Preslan JE, George WJ. Regional chemotherapy for inoperable pancreatic carcinoma. Cancer 1996;78:664-73.
12. Theoders A, Bukowski R, Hewlett J, et al. Intermittent regional infusion of chemotherapy for pancreatic carcinoma. Am J Clin Oncol 1982;27:377-81.
13. Hafstrom L, Ihse I, Josson P, et al. Intraarterial 5-FU infusion with or without oral testolactone treatment in irresectable pancreatic cancer. Acta Chir Scand 1980;146:445-8.
14. Smith L, Gazet J. Intra-arterial chemotherapy for patients with inoperable carcinoma of head of the pancreas. Ann R Coll Surg Engl 1980;62:208-12.