Phase 2 clinical trial of a vaginal mucosal vaccine for urinary tract infections

Journal of Urology

Volumn 170, Issue 3, 2003, Pages 867-869

  Uehling, David T ^a   Hopkins, Walter J ^b   Elkahwaji, Johny E ^b   Schmidt, Dianne M ^b   Leverson, Glen E ^b  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b NONE

Author keywords

Bladder; Mucosal immunity; Urinary tract infections; Vaccines; Vagina

Indexed keywords

ANTIBIOTIC AGENT; BACTERIAL VACCINE; PLACEBO; UNCLASSIFIED DRUG; UROVAC; VAGINA MUCOSAL VACCINE;

ADULT; AGED; ANTIBIOTIC PROPHYLAXIS; ARTICLE; BACTERIAL STRAIN; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG FORMULATION; DRUG INDUCED DISEASE; DRUG SAFETY; ENTEROCOCCUS FAECALIS; FEMALE; HUMAN; IMMUNIZATION; INFECTION SENSITIVITY; KLEBSIELLA PNEUMONIAE; LONG TERM CARE; MAJOR CLINICAL STUDY; MORGANELLA MORGANII; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; PROTEUS MIRABILIS; RANDOMIZED CONTROLLED TRIAL; RECURRENT INFECTION; SEXUAL DYSFUNCTION; SUPPOSITORY; URINARY TRACT INFECTION; VACCINATION; VAGINA DISCHARGE; VAGINA MUCOSA;

EID: 0041736550     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ju.0000075094.54767.6e     Document Type: Article

References (21)

1. Warren, J. W.: Clinical presentation and epidemiology of urinary tract infections. In: Urinary Tract Infection. Edited by H. L. Mobley and J. L. Warren. Washington, D. C.: ASM Press, pp. 3-27, 1996
2. Kunin, C. M.: Urinary Tract Infections: Detection, Prevention, and Management, 5th ed. Baltimore: Williams & Wilkins Co., 1997
3. Kunin, C. M.: Urinary tract infections in females. Clin Infect Dis, 18: 1, 1994
4. Foxman, B.: Recurring urinary tract infections: incidence and risk factors. Am J Public Health, 80: 331, 1990
5. Hooton, T. M., Scholes, D., Hughes, J. P., Winter, C., Roberts, P. L., Stapleton, A. E. et al: A prospective study of risk factors for symptomatic urinary tract infection in young women. N Engl J Med, 335: 468, 1996
6. Ronald, A. R., Nicolle, L. E., Stamm, E., Krieger, J., Warren, J., Schaeffer, A. et al: Urinary tract infection in adults: research priorities and strategies. Int J Antimicrob Agents, 17: 343, 2001
7. Manges, A. R., Johnson, J. R., Foxman, B., O'Bryan, T. T., Fullerton, K. E. and Riley, L. W.: Widespread distribution of urinary tract infections caused by a multidrug-resistant Escherichia coli clonal group. N Engl J Med, 345: 1007, 2001
8. Sahm, D. F., Thornsberry, C., Mayfield, D. C., Jones, M. E. and Karlowsky, J. A.: Multidrug-resistant urinary tract isolates of Escherichia coli: prevalence and patient demographics in the United States in 2000. Antimicrob Agents Chemother, 45: 1402, 2001
9. Uehling, D. T., Jensen, J. and Balish, E.: Vaginal immunization against urinary tract infection. J Urol, 128: 1382, 1982
10. Uehling, D. T., Hopkins, W. J., James, L. J. and Balish, E.: Vaginal immunization of monkeys against urinary tract infection with a multi-strain vaccine. J Urol, 151: 214, 1994
11. Uehling, D. T., James, L. J., Hopkins, W. J. and Balish, E.: Immunization against urinary tract infection with a multivalent vaginal vaccine. J Urol, 146: 223, 1991
12. Uehling, D. T., Hopkins, W. J., Dahmer, L. A. and Balish, E.: Phase I clinical trial of vaginal mucosal immunization for recurrent urinary tract infection. J Urol, 152: 2308, 1994
13. Uehling, D. T., Hopkins, W. J., Beierle, L. M., Kryger, J. V. and Heisey, D. M.: Vaginal mucosal immunization for recurrent urinary tract infection: extended phase II clinical trial. J Infect Dis, suppl., 183: S81, 2001
14. Kruze, D., Biro, K., Holzbecher, K., Andrial, M. and Bossart, W.: Protection by a polyvalent vaccine against challenge infection and pyelonephritis. Urol Res, 20: 177, 1992
15. Kruze, D., Holzbecher, K., Andrial, M. and Bossart, W.: Urinary antibody response after immunisation with a vaccine against urinary tract infection. Urol Res, 17: 361, 1989
16. Gupta, K., Stapleton, A. E., Hooton, T. M., Roberts, P. L., Fennell, C. L. and Stamm, W. E.: Inverse association of H2O2-producing lactobacilli and vaginal Escherichia coli colonization in women with recurrent urinary tract infections. J Infect Dis, 178: 446, 1998
17. Hopkins, W. J., Uehling, D. T. and Balish, E.: Local and systemic antibody responses accompany spontaneous resolution of experimental cystitis in cynomolgus monkeys. Infect Immun, 55: 1951, 1987
18. Gupta, K., Sahm, D. F., Mayfield, D. and Stamm, W. E.: Antimicrobial resistance among uropathogens that cause community-acquired urinary tract infections in women: a nationwide analysis. Clin Infect Dis, 33: 89, 2001
19. Hopkins, W. J. and Uehling, D. T.: Vaccine development for the prevention of urinary tract infections. Curr Infect Dis Rep, 4: 509, 2002
20. Eden, C. S., Hanson, L. A., Jodal, U., Lindberg, U. and Akerlund, A. S.: Variable adherence to normal human urinary-tract epithelial cells of Escherichia coli strains associated with various forms of urinary-tract infection. Lancet, 1: 490, 1976
21. Kozlowski, P. A., Williams, S. B., Lynch, R. M., Flanigan, T. P., Patterson, R. R., Cu-Uvin, S. et al: Differential induction of mucosal and systemic antibody responses in women after nasal, rectal, or vaginal immunization: influence of the menstrual cycle. J Immunol, 169: 566, 2002