The action of oxybutynin on haemodynamics and metabolism in the perfused rat liver

Pharmacology and Toxicology

Volumn 93, Issue 3, 2003, Pages 147-152

  Fernando Comar, Jurandir ^a   Suzuki Kemmelmeier, Fumie ^a   Bracht, Adelar ^a  

^a STATE UNIVERSITY OF MARINGÁ   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE NUCLEOTIDE; ADENOSINE DIPHOSPHATE; ADENOSINE PHOSPHATE; BICARBONATE; BUFFER; CALCIUM; CALCIUM ION; GLUCOSE; GLUCOSE 6 PHOSPHATE; LACTIC ACID; MANDELIC ACID DERIVATIVE; MUSCARINIC RECEPTOR BLOCKING AGENT; OXYBUTYNIN; OXYGEN; PYRUVIC ACID;

ANIMAL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG INFUSION; DRUG MECHANISM; GLUCOSE METABOLISM; HEMODYNAMICS; HEPATIC ARTERY; IN VITRO STUDY; ISOLATED LIVER; LIVER; LIVER METABOLISM; LIVER PARENCHYMA; LIVER PERFUSION; MALE; METABOLISM; NONHUMAN; OXYGEN CONSUMPTION; PERFUSION PRESSURE; PH; PHYSIOLOGY; PRIORITY JOURNAL; RAT; RAT STRAIN; TIME; VASCULARIZATION;

ADENINE NUCLEOTIDES; ANIMALS; CALCIUM; GLUCOSE; GLUCOSE-6-PHOSPHATE; HEMODYNAMIC PROCESSES; LACTIC ACID; LIVER; MALE; MANDELIC ACIDS; MUSCARINIC ANTAGONISTS; PYRUVIC ACID; RATS; RATS, WISTAR;

ANIMALIA;

EID: 0041735137     PISSN: 09019928     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0773.2003.930307.x     Document Type: Article

References (33)

1. Bergmeyer, H. U. & E. Bernt: Determination of glucose with glucose oxidase and peroxidase. In: Methods of enzymatic analysis. Ed.: H. U. Bergmeyer. Verlag Chemie-Academic Press, Weinhelm-London, 1974, pp. 1205-1215.
2. Bergmeyer, H. U., E. Bernt, F. Schmidt & H. Stork: D-Glucose. Determination with hexokinase and glucose-6-phosphate dehydrogenase. In: Methods of enzymatic analysis. Ed.: H. U. Bergmeyer. Verlag Chemie-Academic Press, Weinheim-London, 1974, pp. 1196-201.
3. 2+ and hemodynamics in the action of diltiazem on hepatic energy metabolism. Cell Biol. Toxicol. 1999a, 15, 217-227.
4. 2+ dependent. Liver 1999b, 19, 145-150.
5. Bracht, A., E. L. Ishii-Iwamoto & A. M. Kelmer-Bracht: O estudo do metabolismo no figado em perfusão. In: Métodos de laboratório em bioquímica. Eds.: A. Bracht & E.L. Ishii-Iwamoto. Editora Manole, São Paulo, Brazil, 2003, pp. 275-289.
6. Brauer, R. W.: Liver circulation and function. Physiol. Rev. 1963, 43, 115-215.
7. Buxton, D. B., R. A. Fisher, S. M. Robertson & M. S. Olson: Stimulation of glycogenolysis and vasoconstriction by adenosine and adenosine analogues in the perfused rat liver. Biochem. J. 1987, 248, 35-41.
8. Constantin, J., E. L. Ishii-Iwamoto, F. Suzuki-Kemmelmeier, N. Yamamoto & A. Bracht: Bivascular liver perfusion in the anterograde and retrograde modes. Zonation of the response to inhibitors of oxidative phosphorylation. Cell Biochem. Funct. 1995, 13, 201-209.
9. Czok, R. & W. Lamprecht: Pyruvate, phosphoenolpyruvate and D-glycerate-2-phosphate. In: Methods of enzymatic analysis. Ed.: H. U. Bergmeyer. Verlag Chemie-Academic Press, Weinheim-London, 1974, pp. 1446-1451.
10. Diokno, A. C. & J. Lapides: Oxybutynin: A new drug with analgesic and anticholinergic properties. J. Urol. 1972, 108, 307-309.
11. Douchamps, J., F. Derenne, S. Stockis, D. Gangji, M. Juvent, & A. Herchuelz: The pharmacokinetics of oxybutynin in man. Eur. J. Clin. Pharmacol. 1988, 35, 515-520.
12. Gutman, J. & A. W. Wahlefeld: L-(+)-Lactate determination with lactate dehydrogenase and NAD. In: Methods of enzymatic analysis. Ed.: H. U. Bergmeyer. Verlag Chemie-Academic Press, Weinhelm-London, 1974, pp. 1464-1468.
13. Hughes, K. M., J. C. T Lang, R. Lazare, D. Gordon, S. L. Stanton, J. Malone-Lee & M. Geraint: Measurement of oxybutynin and its N-desethyl metabolite in plasma, and its application to pharmacokinetic studies in young, elderly and frail elderly volunters. Xenobiotica 1992, 22, 859-869.
14. Häussinger, D., T. Stehle, W. Gerok, T. Tran-Thi & K. Decker: Hepatocyte heterogeneity in response to extracellular ATP. Eur. J. Biochem. 1987, 169, 645-650.
15. Itinose, A. M., M. L. Doi-Sakuno & A. Bracht: Metabolic effects of acetaminophen. Studies in the isolated perfused rat liver. Cell Biochem. Funct. 1989, 7, 263-273.
16. Jaworek, D., W Gruber & H. U. Bergmeyer: Adenosine 5′-diphosphate and adenosine 5′-mono-phoshate. In: Methods of enzymatic analysis. Ed.: H. U. Bergmeyer. Verlag Chemie-Academic Press, Weinheim-London, 1974, pp. 2127-2131.
17. Kachur, J. F., J. S. Peterson, J. P. Carter, W. Janusz Rzeszotarski, R. C. Hanson, L. R. Noronha-Blob: R and S enantiomers of oxybutynin: Pharmacological effects in guinea pig bladder and intestine. J. Pharmacol. Exp. Therap. 1988, 247, 867-872.
18. Kelmer-Bracht, A. M., E. L. Ishii, P. V. M. de Andrade & A. Bracht: Construction of a liver perfusion apparatus for studies on metabolic regulation and mechanisms of drug action. Arq. Biol. Tecnol. 1984, 27, 419-438.
19. Lamprecht, W. & I. Trautschold: Adenosine-5′-triphosphate. Determination with hexokinase and glucose-6-phosphate dehydrogenase. In: Methods of enzymatic analysis. Ed.: H. U. Bergmeyer. Verlag Chemie-Academic Press, Weinheim-London, 1974, 2101-2110.
20. Lenzen, R., W. Stremmel & G. Strohmeyer: Antiarrhytmic drugs impair uptake and secretory function by different mechanisms in the isolated pefused rat lver. Biochim. Biophys. Acta 1991, 1074, 406-412.
21. Lindeke, B. & O. Ericsson: Metabolism of oxybutynin: Establishment of desethyloxybutynin and oxybutynin N-oxide formation in rat liver preparations using deuterium substitution and gas chromatographic mass spectrometric analysis. Biomed. Mass Spectrometry 1981, 8, 506-513.
22. Lish, P. M., J. A. Labudde, E. L. Peters & S. I. Robbins: Oxybutynin - a musculotropic antispasmodic drug with moderate anticholinergic action. Arch. Int. Pharmacodyn. 1965, 156, 467-488.
23. Lukkari, E., P. Taavitsainen, A. Juhakoski & O. Pelkonen: Cytochrome P450 specificity of metabolism and interactions of oxybutynin in human liver microsomes. Pharmacology & Toxicology 1998, 82, 161-166.
24. Moisey, C. U., T. P. Stephenson & C. B. Brendler: The urodynamic and subjective results of treatment of detrusor instability with oxybutynin chloride. Brit. J. Urol. 1980, 52, 472-475.
25. Noronha-Blob, L. & J. F. Kachur: Enantiomers of oxybutynin: In vitro pharmacological characterization at M1, M2 and M3 muscarinic receptors and in vivo effects on urinary bladder contraction, mydriasis and salivary secretion in guinea pigs. J. Pharmacol. Exp. Therap. 1991, 256, 562-567.
26. Oki, T., S. Yamada, A. Tohma & R. Kimura: Muscarinic receptor binding characteristcs in rat tissues after oral administration of oxybutynin and propiverine. Biol. Pharm. Bull. 2001, 24, 491-495.
27. Scholz, R. & T. Bücher: Hemoglobin-free perfusion of rat liver. In: Control of energy metabolism. Eds.: B. Chance, R. W. Estabrook & J. R. Williamson. New York, Academic Press, 1965, pp. 393-414.
28. Suzuki-Kemmelmeier, F., E. L. Ishii-Iwamoto & A. Bracht: The metabolism of fructose in the bivasculary perfused rat liver. Biochim. Biophys. Acta 1992, 1116, 275-282.
29. Thompson, I. M. & R. Lauvetz: Oxybutynin in bladder spasm, neurogenic bladder, and enuresis. Urology 1976, 8, 452-454.
30. Tonini, M., C. A. Rizzi, F. Perucca, F. De Ponti, L. D'Angelo, A. Del Vecchio & A. Crema: Depressant action of oxybutynin on the contractility of intestinal and urinary tract smooth muscle. J. Pharm. Pharmacol. 1987, 39, 103-107.
31. Waldeck, K., B. Larsson & K. Andersson: Comparison of oxybutynin and its active metabolite, N-desethyloxybutynin, in the human detrusor and parotid gland. J. Urol. 1997, 157, 1093-1097.
32. Wayne, L. W.: Mechanism and role of intrinsic regulation of hepatic arterial blood flow: hepatic arterial buffer response. Amer. J. Physiol. 1985, 249, G549-G556.
33. Yamamoto, N. S., E. L. Ishii-Iwamoto & A. Bracht. Activation of glycogenolysis by methotrexate: effects of calcium and inhibitors of hormone action. Biochem. Pharmacol. 1992, 44, 761-767.