Study on the chiral separation of securinine by high-performance capillary electrophoresis and its stereoselective metabolism in rat

Yaoxue Xuebao

Volumn 37, Issue 1, 2002, Pages 50-53

  Li, Xiao Hai ^a   Zhang, Jin Lan ^a   Zhou, Tong Hui ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Chiral drug; Chiral separation; HPCE; Securinine; Stereoselective metabolism

Indexed keywords

ALKALOID; AZEPINE DERIVATIVE; FUSED HETEROCYCLIC RINGS; LACTONE; PIPERIDINE DERIVATIVE; SECURININE;

ANIMAL; ARTICLE; BILE; CAPILLARY ELECTROPHORESIS; CHEMICAL STRUCTURE; CHEMISTRY; EUPHORBIA; ISOLATION AND PURIFICATION; MALE; MEDICINAL PLANT; METABOLISM; METHODOLOGY; RAT; STEREOISOMERISM; URINE; WISTAR RAT;

ALKALOIDS; ANIMALS; AZEPINES; BILE; ELECTROPHORESIS, CAPILLARY; EUPHORBIACEAE; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; LACTONES; MALE; MOLECULAR STRUCTURE; PIPERIDINES; PLANTS, MEDICINAL; RATS; RATS, WISTAR; STEREOISOMERISM;

EID: 0041732100     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Yang CL, Li LQ, Shu LS. The treatment of aplastic anemia. Tianjin Med J [J], 1981,9(11):662-665.
2. Dong NZ, Gu ZL. Study on the antitumor effect of securinine and its mechanism. Chin Tradit Pat Med [J], 1999,21(4):193-195.
3. Jiang XY. The effect of securinine and aminophylline on hemopoietic stem cells and granulopoietic progenitors in mice. Tianjin Med J [J], 1982,10(2):99-100.
4. Liu WJ, Gu ZL, Zhou WX. Securinine induced apoptosis in K562 cells. Chin Pharmacol Bull [J], 1999,15(2):135-138.
5. Xing JD, Xu YJ, Zheng XD. Study on the antivirus activity to HSV-1 of securinine in vitro and the preparation of securinine gutta. Chin Pharm J [J], 1996,31(11):684-685.
6. Cheng YH, Song WZ. Optical activity and assay of securinine in Secarinega suffruticosa Rehd of different districts. Bull Trad Chin Med [J], 1978, (2):12-13.
7. Zhang JT, Qu ZW. Comparison of d-securinine and l-securinine metabolism in mice and rats. Proc Chin Acad Med Sci and Peking Union Med Coll [J], 1986,1(2):105-108.
8. Sandra Z, Wolfgang T. Enantioselective determination of drugs in body fluids by capillary electrophoresis. J Chromatogr A [J], 2000,875(1):27-41.
9. Nishi H, Terabe S. Optical resolution of drugs by capillary electrophoretic techniques. J Chromatogr [J], 1995, 694 (1):245-276.
10. Zhu XF, Lin BC. Chiral resolution by capillary electrophoresis. Chin J Chromatogr (EU) [J], 1999, 17 (2):153-157.
11. Li G. Clinical stereoselective pharmacokinetics of chiral drugs. Chin J Hosp Pharm [J], 1999,19(7):429-431.