Synthesis and Cytotoxicity of Platinum(II) Complexes of 3-Aminocyclopentanespiro-5-hydantoin and 3-Aminocycloheptanespiro-5-hydantoin

Zeitschrift fur Naturforschung - Section C Journal of Biosciences

Volumn 58, Issue 1-2, 2003, Pages 103-108

  Kushev, Daniel ^a   Maneva, Liliana ^a   Grancharov, Konstantin ^a   Spassovska, Nadejda ^a   Naydenova, Emilya ^b   Popova, Julita ^b  

^a INSTITUTE OF MOLECULAR BIOLOGY   (Bulgaria)

^b Chem Technol/Metall University   (Bulgaria)

Author keywords

Antibacterial Effect; Cytotoxic Effects; Platinum(II) Complexes

Indexed keywords

ANIMALS; ANTI-BACTERIAL AGENTS; ANTINEOPLASTIC AGENTS; BACTERIA; CELL LINE; CELL SURVIVAL; DNA REPLICATION; HYDANTOINS; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; ORGANOPLATINUM COMPOUNDS; SPECTROPHOTOMETRY, INFRARED; SPIRO COMPOUNDS;

BACTERIA (MICROORGANISMS); MURINAE;

EID: 0041696134     PISSN: 09395075     EISSN: None     Source Type: Journal    
DOI: 10.1515/znc-2003-1-218     Document Type: Article

References (20)

1. Avendano C., and Gonzales C. (1985), The chemistry of hydantoins. Adv. Heterocyclic Chem. 38, 177-228.
2. Bitha P., Carvajal S. G., Citarella R. V., Delos Santos E. F., Durr F. E., Hlavka J. J., Lang S. A., Lindsay H. L., Thomas J. P., Wallace R. E., and Lin Y. (1989), A new family of water-soluble, third generation antitumor platinum complexes. J. Med. Chem. 32, 2063-2067.
3. Bucherer H., and Lieb V. (1934), Über die Bildung substituierter Hydantoine aus Aldehyden und Ketonen. J. Prakt. Chem. 141, 5-43.
4. Bunker J. C., and James A. M. (1989), Microcalorimetric studies of the effects of platinum group metal complexes on bacterial growth. Microbios 58, 83-93.
5. De Conti R., Toftiness B., Lange R., and Creasy W. (1973), Clinical and pharmacological studies with cis-diamminedichloroplatinum (II). Cancer Res. 33, 1310-1315.
6. Dube S. K., Pragnell I. B., Kluge N., Gaedicke G., Stein-heider G., and Ostertag W. (1975), Induction of endogenous and of spleen focus-forming viruses during dimethylsulfoxide-induced differentiation of mouse erythroleukemia cell transformed by spleen focus-forming. Proc. Natl. Acad. Sci. USA 72, 1863-1867.
7. Dulbecco R., and Freeman G. (1959), Plaque production by the Polyoma virus. Virology 8, 396-397.
8. Eastman A., Schulte N., Sheibani N., and Sorensen C. M. (1988), Mechanisms of resistance to platinum drugs. In Platinum and Other Metal Compounds in Cancer Chemotherapy. (M. Nikolini, ed.). Martinus Nijhoff Publ., Boston, pp. 178-196.
9. Ferguson C. A., Marry R. G. E., and Lancy P. (1979), Effects of some platinum (IV) complexes on cell division of Escherichia coli. Can. J. Micr. 25, 545-559.
10. Grancharov K. C., Koch M., Volm M., and Kolar G. F. (1988), Synthesis and cytotoxic effects of hydroxymethyl-3-pyridyl-and 2-chloro-5-pyridyltriazene derivatives. Cancer Lett. 41, 271-279.
11. Kerrison S. J. S., and Sadler P. J. (1977), Solvolysis of cis-[Pt (NH3) 2Cl2] in dimethyl sulphoxide and reactions of glycine with [PtCl3 (Me2SO)]-as probed by 195Pt nuclear magnetic resonance shifts and 195Pt-15N coupling constants. J. Chem. Soc., Chem. Commun. 23, 861-863.
12. Kharitonov Y. U., Machkhoshvili R., Kravchenko A., and Shchelokov R. (1975), Platinum (II) complex compounds with methoxybenzoylhydrazine isomers. Koord. Khim. 1 (3), 323-332.
13. Kushev D., Gorneva G., Enchev V., Naydenova E., Popova J., Taxirov S., Maneva L., Grancharov K., and Spassovska N. (2002), Syntesis, cytotoxicity, antibacterial and antitumor activity of platinum (II) complexes of 3-amino-cyclohexanespiro-5-hydantoin. J. Inorg. Biochem. 89, 203-211.
14. Kushev D., Gorneva G., Taxirov S., Spassovska N., and Grancharov K. (1999), Synthesis, cytotoxicity and antitumor activity of platinum (II) complexes of cyclo-pentanecarboxylic acid hydrazide. Biol. Chem. 380, 1287-1294.
15. Loehrer P., and Einhorn I. (1984), Cisplatin. Ann. Intern. Med. 100, 704-713.
16. Muir M., Cadiz M., and Baez A. (1988), Synthesis and characterization of new platinum (II) complexes containing thiazole and imidazole donors. Inorg. Chim. Acta 151, 209-213.
17. Reiner R. (1982), Antibiotics: An Introduction, Thieme Stratton Publ., Stuttgart, New York, pp. 21-23.
18. Rosenberg B., Van Camp L., Grimley E. B., and Thom-som A. J. (1967), The inhibition of cell growth or cell division in Escherichia coli by different ionic species of platinum (II) complexes. J. Biol. Chem. 242, 1347-1352.
19. Spassovska N. C., Bonchev P. R., Grancharov K. C., and Golovinsky E. V. (1981), Method for synthesis of cis-diamminedichloroplatinum (II). Bulgarian Patent No 54667.
20. Struck R., Kirk H., Rice L. S., and Suling W. J. (1986), Isolation, synthesis and antitumor evaluation of spirohydantoin aziridine, a mutagenic metabolite of spirohydantoin mustard. J. Med. Chem. 29, 1319-1321.