Ileum-targeted steroid therapy in rheumatoid arthritis: Double-blind, placebo-controlled trial of controlled-release budesonide

Rheumatology International

Volumn 23, Issue 4, 2003, Pages 154-158

  Sheldon, P ^a,b  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b LEICESTER ROYAL INFIRMARY   (United Kingdom)

Author keywords

Corticosteroid therapy; Mucosal immune system; Rheumatoid arthritis

Indexed keywords

ANTIRHEUMATIC AGENT; AURANOFIN; BUDESONIDE; C REACTIVE PROTEIN; CORTICOSTEROID; HEMOGLOBIN; HYDROCORTISONE; HYDROXYCHLOROQUINE; METHOTREXATE; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; PLACEBO; SALAZOSULFAPYRIDINE;

ADULT; AGED; ARTICLE; BLOOD PRESSURE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; CORTICOSTEROID THERAPY; DIARRHEA; DISEASE ACTIVITY; DOUBLE BLIND PROCEDURE; DYSURIA; ERYTHROCYTE SEDIMENTATION RATE; FECES COLOR; FEMALE; GRIP STRENGTH; HEADACHE; HUMAN; HYDROCORTISONE BLOOD LEVEL; ILEUM; INFLUENZA; JOINT STIFFNESS; LOW BACK PAIN; MALE; NAUSEA; PAIN ASSESSMENT; PLASMA VISCOSITY; PRIORITY JOURNAL; RASH; RHEUMATOID ARTHRITIS; VISUAL ANALOG SCALE;

ADMINISTRATION, ORAL; ADMINISTRATION, TOPICAL; ADULT; ANTI-INFLAMMATORY AGENTS; ARTHRITIS, RHEUMATOID; BUDESONIDE; DELAYED-ACTION PREPARATIONS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; ILEUM; MALE; MIDDLE AGED; TREATMENT OUTCOME;

EID: 0041658953     PISSN: 01728172     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00296-002-0278-8     Document Type: Article

References (17)

1. Forestier J (1935) Rheumatoid arthritis and its treatment by gold salts. J Lab Clin Med 20: 827
2. Jaffe IA (1963) Comparison of the effect of plasmapheresis and penicillamine on the level of circulating rheumatoid factor. Ann Rheum Dis 22: 71
3. McConkey B, Amos RS, Durham S et al (1980) Sulphasalazine in rheumatoid arthritis. Br Med J 2: 442-444
4. Freedman A, Steinberg VL (1960) Chloroquine in rheumatoid arthritis, a double blindfold trial of treatment for one year. Ann Rheum Dis 19: 243
5. Willkens RF (1983) Reappraisal of the use of methotrexate in rheumatoid arthritis. Am J Med 75 [Suppl 4B]: 19
6. Yocum DE, Klippel JH, Wilder RL et al (1988) Cyclosporin A in severe, treatment refractory, rheumatoid arthritis. Ann Intern Med 109: 863-869
7. Sheldon P, Webb C, Grindulis KA (1988) Effect of sulphasalazine and its metabolites on mitogen induced lymphocyte transformation - clues to its clinical action? Br J Rheumatol 27: 344-349
8. Hench PS, Kendall EC, Slocumb CH, Polley HF (1949) The effect of a hormone of the adrenal cortex (17-hydroxy-11-dehydrocorticosterone: compound E) and of pituitary adrenocorticotropic hormone on rheumatoid arthritis. Proc Staff Meet Mayo Clin 24: 181-197
9. Kirwan JR, ARC Low-Dose Glucocorticosteroid Study Group (1995) The effect of glucocorticoid on joint destruction in rheumatoid arthritis. N Engl J Med 333: 142-146
10. Markham A, Bryson HM (1995) Deflazcort: a review of its pharmacological properties and therapeutic efficiency. Drugs 50: 317-333
11. Speight TM, Holford NHG (1997) Avery's drug treatment. Fourth edn. A guide to the properties, choice, therapeutic use and economic value of drugs in disease management. Adis International, Auckland
12. Sheldon P (1988) Rheumatoid arthritis and gut related lymphocytes: the iteropathy concept. Ann Rheum Dis 47: 697-700
13. Kadioglu A, Sheldon P (1998) Steroid pulse therapy for rheumatoid arthritis: effect on lymphocyte subsets and mononuclear cell adhesion. Br J Rheum 37: 282-286
14. Lofberg R, Danielsson A, Salde L (1993) Oral budesonide in active Crohn's disease. Aliment Pharmacol Ther 7: 611-616
15. Rutgeerts P, Lofberg R, Malchow H et al (1994) A comparison of budesonide with prednisolone for active Crohn's disease. N Engl J Med 331: 842-845
16. Spencer CM, McTavish D (1995) Budesonide: a review of its pharmacological properties and therapeutic efficiency in inflammatory bowel disease. Drugs 50: 854-872
17. Edsbacker S, Larsson P, Nilsson M et al (1995) Budesonide controlled ileal release (CIR) capsules affect plasma cortisol less than prednisolone. Gastroenterology 106: A814