KL-6, a human MUC1 mucin, is expressed early in premature lung

Respiratory Medicine

Volumn 97, Issue 8, 2003, Pages 964-969

  Sun, A P ^a   Ohtsuki, Y ^a   Fujita, J ^b   Ishida, T ^b   Yoshinouchi, T ^c   Kohno, N ^d  

^a KOCHI MEDICAL SCHOOL   (Japan)

^b KAGAWA UNIVERSITY   (Japan)

^c NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

^d HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

Hyaline membrane; Immunohistochemistry; KL 6; MUC1; Premature lung; Surfactant protein A

Indexed keywords

BIOLOGICAL MARKER; GLYCOPROTEIN; MUCIN 1; PROTEIN KL 6; SURFACTANT PROTEIN A; UNCLASSIFIED DRUG;

ARTICLE; AUTOPSY; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; EMBRYO DEVELOPMENT; EPITHELIUM; FEMALE; FETUS; FETUS LUNG MATURITY; GESTATIONAL AGE; HUMAN; HUMAN TISSUE; HYALINE MEMBRANE DISEASE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INFANT; INTERSTITIAL PNEUMONIA; LUNG ALVEOLUS CELL TYPE 2; LUNG DEVELOPMENT; MALE; MOLECULAR WEIGHT; NEWBORN; PERINATAL PERIOD; PREMATURITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SURVIVAL;

EID: 0041630639     PISSN: 09546111     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0954-6111(03)00124-0     Document Type: Article

References (28)

1. Kohno N, Akiyama M, Kyoizumi S, Hakoda M, Kobuke K, Yamakido M. Detection of soluble tumor-associated antigens in sera and effusions using novel monoclonal antibodies, KL-3 and KL-6, against lung adenocarcinoma. Jpn J Clin Oncol 1988;18:203-16.
2. Stahel RA, Giks WR, Lehmann HP, Schenker T. Third international workshop on lung tumor and differentiation antigens: overview of the results of the central data analysis. Int J Cancer 1994;8:6-26.
3. Wesseling J, van der Valk SW, Vos HL, Sonnenberg A, Hilkens J. Episialin (MUC1) overexpression inhibits integrin-mediated cell adhesion to extracellular matrix components. J Cell Biol 1995;129:255-65.
4. Wesseling J, van der Valk SW, Hilkens J. A mechanism for inhibition of E-cadherin-mediated cell-cell adhesion by the membranes-associated mucin episialin/MUC1. Mol Biol Cell 1996;7:565-77.
5. Guddo F, Giatromanolaki A, Patriarca C, et al. Depolarized expression of episialin (EMA, MUC1) in lung adenocarcinoma is associated with tumor progression. Anticancer Res 1998;18:1915-20.
6. Agrawal B, Krantz MJ, Reddish MA, Longenecker BM. Cancer-associated MUC1 mucin inhibits human T-cell proliferation, which is reversible by IL-2. Nat Med 1998;4:43-9.
7. Mannori G, Crottet P, Cecconi O, et al. Differential colon cancer cell adhesion to E-, P-, and L-selectin: role of mucin type glycoproteins. Cancer Res 1995;55:4425-31.
8. Braga VM, Pemberton LF, Duhig T, Gendler SJ. Spatial and temporal expression of an epithelial. mucin, Muc-1, during mouse development. Development 1992;115:427-37.
9. Peat N, Gendler SJ, Lalani N, Duhig T, Taylor-Papadimitriou J. Tissue-specific expression of a human polymorphic epithelial mucin (MUC1) in transgenic mice. Cancer Res 1992;52:1954-60.
10. Chambers JA, Hollingsworth MA, Trezise AE, Harris A. Developmental expression of mucin genes MUC1 and MUC2. J Cell Sci 1994;107:413-24.
11. Parry G, Li J, Stubbs J, Bissell M, Schmidhanser C, Spicer AP, Gendler SJ. Studies of Muc-1 mucin expression and polarity in the mouse mammary gland demonstrate developmental regulation of Muc-1 glycosylation and establish the hormonal basis for mRNA expression. J Cell Sci 1992;101:191-9.
12. Kohno N, Kyoizumi S, Awaya Y, Fukuhata H, Yamakido M, Akiyama M. New serum indicator of interstitial pneumonitits activity. Sialylated carbohydrated antigen KL-6. Chest 1989;96:68-73.
13. Hamada H, Kohno N, Akiyama M, Hiwada K. Monitoring of serum KL-6 antigen in a patient with radiation pneumonia. Chest 1992;101:858-60.
14. Kobayashi J, Kitamura S. KL-6: a serum marker for interstitial pneumonia. Chest 1995;108:311-5.
15. Kobayashi J, Kitamura S. Serum KL-6 for the evaluation of active pneumonitis in pulmonary sarcoidosis. Chest 1996; 109:1276-82.
16. Hudson MJ, Stamp GW, Chaudhary KS, et al. Human MUC1 mucin: a potent glandular morphogen. J Pathol 2001;194:373-83.
17. Spicer AP, Rowse GJ, Lidner TK, Gendler SJ. Delayed mammary tumor progression in Muc-1 null mice. J Biol Chem 1995;270:30093-101.
18. Lambrechts MG, Bauer FF, Marmur J, Pretorius IS. Muc1, a mucin-like protein that is regulated by Mss10, is critical for pseudohyphal differentiation in yeast. Proc Natl Acad Sci USA 1996;93:8419-24.
19. Gancedo JM. Control of pseudohyphae formation in Saccharomyces cerevisiae. FEMS Microbiol Rev 2001;25:107-23.
20. Ho SB, Niehans GA, Lyftogt C, et al. Heterogeneity of mucin gene expression in normal and neoplastic tissues. Cancer Res 1993;53:641-51.
21. Aoki R, Tanaka S, Haruma K, et al. MUC-1 expression as predictor of the curative endoscopic treatment of submucosally invasive colorectal carcinoma. Dis Colon Rectum 1998;41:1262-72.
22. Chu JS, Chang KJ. Mucin expression in mucinous carcinoma and other invasive carcinomas of the breast. Cancer Lett 1999;142:121-7.
23. Hirasawa Y, Kohno N, Yokoyama A, Inoue Y, Abe M, Hiwada K. KL-6, a human MUC1 mucin, is chemotactic for human fibroblasts. Am J Respir Cell Mol Biol 1997;17:501-7.
24. Stiles AD. Moats-Staats. Production and action of insulin-like growth factor I/somatomedin C in primary cultures of fetal lung fibroblasts. Am J Respir Cell Mol Biol 1989;1:21-6.
25. D'Ercole AJ. Somatomedins/insulin-like growth factors and fetal development. J Dev Physiol 1987;9:481-95.
26. Stiles AD, D'Ercole AJ. The insulin-like growth factor and the lung. Am J Respir Cell Mol Biol 1990;3:93-100.
27. Mendelson CR, Boggaram V. Hormonal control of the surfactant system in fetal lung. Annu Rev Physiol 1991;53:415-40.
28. Acarregui MJ, Snyder JM, Mendelson CR. Oxygen modulates the differentiation of human fetal lung in vitro and its responsiveness to cyclic AMP. Am J Physiol 1993;264:L465-74.