Pharmacokinetics of ethylene in man by on-line laser photoacoustic detection

Toxicology and Applied Pharmacology

Volumn 190, Issue 3, 2003, Pages 206-213

  Berkelmans, H W A ^b   Moeskops, B W M ^b   Bominaar, J ^b   Scheepers, P T J ^a   Harren, F J M ^b  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

Author keywords

Breath; Closed chamber technique; Ethene; Ethylene; Free radicals; Human; Lipid peroxidation; Pharmacokinetics; Photoacoustic spectroscopy

Indexed keywords

ETHYLENE;

ADULT; ARTICLE; CONTROLLED STUDY; CURVE FITTING; GAS CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; LASER; LIPID PEROXIDATION; MALE; NORMAL HUMAN; PHOTOACOUSTIC SPECTROSCOPY;

EID: 0041592433     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-008X(03)00164-9     Document Type: Article

References (22)

1. 52nd WMA General Assembly, 2000. World Medical Association Declaration of Helsinki-Ethical Principles for Medical Research Involving Human Subjects. Edinburgh, Scotland.
2. Bijnen F., Reuss J., Harren F. Geometrical optimization of a longitudinal resonant photoacoustic cell for sensitive and fast trace gas detection. Rev. Sci. Instrum. 67:1996;2914-2923.
3. Convention for the Protection of Human Rights and Dignity of the Human Being with regard to the Application of Biology and Medicine: Convention on Human Rights and Biomedicine, 1997.
4. Csanády G., Denk B., Pütz C., Kreuzer P., Kessler W., Baur C., Gargas M., Filser J. A physiological toxicokinetic model for exogenous and endogenous ethylene and ethylene oxide in rat, mouse and human formation of 2-hydroxyethyl adducts with hemoglobin and DNA . Toxicol. Appl. Pharmacol. 165:2000;1-23.
5. Denk, B., 1990. Abschätzung des kanzerogenen risikos von ethylen und ethylenoxid für de menschen durch speziesextrapolation von der ratte unter berücksichtigung der pharmokokinetik. Thesis, University of Munich.
6. Esterbauer H. Estimation of peroxidative damage a critical review . Pathol. Biol. 44:1996;25-28.
7. Filser J. The closed chamber technique uptake, endogenous production, excretion, steady-state kinetics and rates of metabolism of gases and vapors. Arch. Toxicol. 66:1992;1-10.
8. Filser J., Denk B., Törnqvist M., Kessler W., Ehrenberg L. Phar- macokinetics of ethylene in man and body burden with ethylene oxide and hydroxylethylation of hemoglobin due to endogenous and environmental ethylene. Arch. Toxicol. 66:1992;157-163.
9. Gelmont D., Stein R., Mead J. The bacterial origin of breath pentane. Biochem. Biophys. Res. Commun. 102:1981;932-936.
10. Harren F., Berkelmans R., Kuiper K., te Lintel Hekkert S., Scheepers P., Dekhuizen R., Hollander P., Parker D. On-line laser photoacoustic detection of ethene in exhaled air as biomarker of ultraviolet radiation of the human skin. Appl. Phys. Lett. 74:1999;1761-1763.
11. Harren F., Cotti G., Oomens J., te Lintel Hekkert S. Photoacoustic spectroscopy in trace gas monitoring. Encycl. Anal. Chem. 3:2000;2203-2222.
12. Harren F., Reuss J. Photoacoustic spectroscopy. Encycl. Appl. Phys. 19:1997;413-435.
13. Johanson G., Filser J. Experimental data from closed chamber gas uptake studies in rodents suggest lower uptake rate of chemical than calculated from literature values on alveolar ventilation. Arch. Toxicol. 66:1992;291-295.
14. Johanson G., Filser J. PBPK model for butadiene metabolism to expoxides quantitative species differences in metabolism . Toxicology. 113:1996;40-47.
15. Kessler, W., 1987. Untersuchungen zu aminosaure- und proteinoxidation in eisen/ascorbat- und eisen/ascorbat/gsh-systemen hinsintlich der entstehung von kohlwasserstoffen sowie enzyminaktievierungen. Ph.D. thesis.
16. Kessler W., Remmer H. Generation of volatile hydrocarbons from amino acids and proteins by an iron/ascorbate/GSH system. Biochem. Pharmacol. 39:1990;1347-1351.
17. Kneepkens C., Legage G., Roy C. The potential of the hydrocarbon breath test as a measure of lipid peroxidation. Free Radical Biol. Med. 17:1994;127-160.
18. Lieberman M., Kunishi A., Mapson L., Wardale D. Ethylene production from methionine. Biochem. Pharmacol. 97:1964;449-459.
19. Mosteller R. Simplified calculation of body surface area. N. Engl. J. Med. 317:1987;1098.
20. Steward A., Allott P., Cowles A., Mapleson W.W., Setlow R. Solubility coefficients for inhaled anaesthetics for water, oil and biological media. Br. J. Anaesth. 45:1973;282.
21. Törnqvist M., Gustafsson B., Kautiainen A., Harms-Ringdahl M., Granath F., Ehrenberg L. Unsaturated lipids and intestinal bacteria as sources of endogenous production of ethylene and ethylene oxide. Carcinogenesis. 10:1989;39-41.
22. Voesenek L., Harren F., Bögemann Blom, C., Reuss J. Ethylene production and petiole growth in rumex plants induced by soil water logging the application of a continuous flow system and a laser-driven intracavity photoacoustic detection system . Plant Physiol. 94:1990;1071-1077.