Variable tissue expression of transferrin receptors: Relevance to acute respiratory distress syndrome

European Respiratory Journal

Volumn 22, Issue 2, 2003, Pages 335-341

  Upton, R L ^a   Chen, Y ^a   Mumby, S ^a   Gutteridge, J M C ^a   Anning, P B ^a   Nicholson, A G ^a   Evans, T W ^a   Quinlan, G J ^a  

^a ROYAL BROMPTON HOSPITAL   (United Kingdom)

Author keywords

Acute respiratory distress; Iron regulation; Oxidative stress; Syndrome; Transferrin receptor

Indexed keywords

FERRITIN; IRON; LIPOPOLYSACCHARIDE; MESSENGER RNA; REGULATOR PROTEIN; TRANSFERRIN RECEPTOR;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HEART; HUMAN; HUMAN TISSUE; IRON STORAGE; IRON TRANSPORT; LUNG BIOPSY; LUNG PARENCHYMA; MALE; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; REGULATORY MECHANISM; RESPIRATORY DISTRESS SYNDROME; TISSUE DISTRIBUTION;

ADULT; AGED; ANIMALS; CHILD; DISEASE MODELS, ANIMAL; FEEDBACK, BIOCHEMICAL; FEMALE; FERRITINS; HUMANS; LIPOPOLYSACCHARIDES; LUNG; MALE; MIDDLE AGED; MYOCARDIUM; RATS; RATS, WISTAR; RECEPTORS, TRANSFERRIN; RESPIRATORY DISTRESS SYNDROME, ADULT;

EID: 0041525626     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.03.00075302     Document Type: Article

References (31)

1. Hudson LD, Milberg JA, Anardi D, Mauner RJ. Clinical risks for development of the acute respiratory distress syndrome. Am J Respir Crit Care Med 1995; 151: 293-301.
2. Gutteridge JM, Quinlan GJ, Mumby S, Heath A, Evans TW. Primary plasma antioxidants in adult respiratory distress syndrome patients: changes in iron-oxidizing, iron-binding, and free radical-scavenging proteins. J Lab Clin Med 1994; 124: 263-273.
3. Gutteridge JM, Mumby S, Quinlan GJ, Chung KF, Evans TW. Pro-oxidant iron is present in human pulmonary epithelial lining fluid: implications for oxidative stress in the lung. Biochem Biophys Res Commun 1996; 220: 1024-1027.
4. Halliwell B, Gutteridge JMC. Free Radicals in Biology and Medicine. 3rd Edn. Oxford, Oxford University Press, 1999.
5. Payne SM, Finkelstein RA. The critical role of iron in host-bacterial interactions. J Clin Invest 1978; 61: 1428-1440.
6. Hentze MW, Kuhn LC. Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress. Proc Natl Acad Sci USA 1996; 93: 8175-8182.
7. Ponka P, Lok CN. The transferrin receptor: role in health and disease. Int J Biochem Cell Biol 1999; 31: 1111-1137.
8. Cairo G, Pietrangelo A. Iron regulatory proteins in pathobiology. Biochem J 2000; 352: 241-250.
9. Hanson ES, Leibold EA. Regulation of iron regulatory protein-1 during hypoxia and hypoxia/reoxygenation. J Biol Chem 1998; 273: 7588-7593.
10. Recalcati S, Taramelli D, Conte D, Cairo G. Nitric oxide-mediated induction of ferritin synthesis in J774 macrophages by inflammatory cytokines: role of selective iron regulatory protein-2 downregulation. Blood 1998; 91: 1059-1066.
11. Roberts KP, Griswold MD. Characterization of rat transferrin receptor cDNA: the regulation of transferrin receptor mRNA in testes and in Sertoli cells in culture. Mol Endocrinol 1990; 4: 531-542.
12. Wu CG, Groenink M, Bosma A, Reitsma PH, van Deventer SJ, Chamuleau RA. Rat ferritin-H: cDNA cloning, differential expression and localization during hepatocarcinogenesis. Carcinogenesis 1997; 18: 47-52.
13. Leibold EA, Aziz N, Brown AJ, Munro HN. Conservation in rat liver of light and heavy subunit sequences of mammalian ferritin. Presence of unique octopeptide in the light subunit. J Biol Chem 1984; 259: 4327-4334.
14. Yu Y, Radisky E, Leibold EA. The iron-responsive element binding protein. Purification, cloning and regulation in rat liver. J Biol Chem 1992; 267: 19005-19010.
15. Guo B, Brown FM, Philips JD, Yu Y, Leibold EA. Characterisation and expression of iron-regulatory protein 2 (IRP2). Presence of multiple IRP2 transcripts regulated by intracellular iron levels. J Biol Chem 1995; 270: 16529-16535.
16. Gutteridge JM, Hou YY. Iron complexes and their reactivity in the bleomycin assay for radical-promoting loosely-bound iron. Free Radic Res Commun 1986; 2: 143-151.
17. Leibold EA, Munro HN. Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5′ untranslated region of ferritin heavy- and light-subunits mRNAs. PNAS 1988; 85: 2171-2205.
18. Tacchini L, Bianchi L, Bernelli-Zazzera A, Cairo G. Transferrin receptor induction by hypoxia. HIF-1-mediated transcriptional activation and cell-specific post-transcriptional regulation. J Biol Chem 1999; 274: 24142-24146.
19. Weiss G, Bogdan C, Hentze MW. Pathways for the regulation of macrophage iron metabolism by the anti-inflammatory cytokines IL-4 and IL13. J Immunol 1997; 158: 420-425.
20. Smirnov IM, Bailey K, Flowers CH, Garrigues NW, Wesselius LJ. Effects of TNF-α and IL-1β on iron metabolism by A549 cells and influence on cytotoxicity. Am J Physiol 1999; 277: L257-L263.
21. Ryu SY, Kang BN, Park SJ, Yoon WK, Kim SH, Kim TH. Modulation of transferrin synthesis, transferrin receptor expression, iNOS expression and NO production in mouse macrophages by cytokines, either alone or in combination. Anitcancer Res 2000; 20: 3331-3338.
22. Mulero V, Brock JH. Regulation of iron metabolism in murine J774 macrophages: role of nitric oxide-dependent and -independent pathways following activation with gamma interferon and LPS. Blood 1999; 94: 2383-2389.
23. Kim S, Ponka P. Effects of inferferon-gamma and LPS on macrophage iron metabolism are mediated by nitric oxide-induced degradation of iron regulatory protein 2. J Biol Chem 2000; 275: 6220-6226.
24. Yoshikawa T. Oxy radicals in endotoxin shock. Methods Enzymol 1990; 186: 660-665.
25. Carthew P, Dorman BM, Edwards RE, Francis JE, Smith AG. A unique rodent model for both the cardiotoxic and hepatotoxic effects of prolonged iron overload. Lab Invest 1993; 69: 217-222.
26. Artigas A, Bernard GR, Carlet J, et al. The American-European Consensus Conference on ARDS, part 2. Ventilatory, pharmacologic, supportive therapy, study design strategies, and issues related to recovery and remodeling. Acute respiratory distress syndrome. Am J Respir Crit Care Med 1998; 157: 1332-1347.
27. Wardle EN. Shock lungs: the post-traumatic respiratory distress syndrome. Q J Med 1984; 53: 317-329.
28. Krafft P, Fridrich P, Pernerstorfer T, et al. The acute respiratory distress syndrome: definitions, severity and clinical outcome. An analysis of 101 clinical investigations. Intensive Care Med 1996; 22: 519-529.
29. Wyncoll DL, Evans TW. Acute respiratory distress syndrome. Lancet 1999; 354: 497-501.
30. Wesselius LJ, Williams WL, Bailey K, Vamos S, O'Brien-Ladner AR, Wiegmann T. Iron uptake promotes hyperoxic injury to alveolar macrophages. Am J Respir Crit Care Med 1999; 159: 100-106.
31. Mateos F, Brock JH, Perez-Arellano JL. Iron metabolism in the lower respiratory tract. Thorax 1998; 53: 594-600.