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0042029032
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note
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Since the E/Z geometry of amide groups is not taken into account for the stereochemistry of the oxidation products, the enantioselectivities (ee) in this report are with respect to the stereogenic carbon which originally had a carboxyl group.
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14
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0043030783
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note
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Treatment of a mixture of 5a and 5b (with a ratio of 98 to 2) with acidic methanol at room temperature for 12 h afforded a thermodynamic ratio of 37 to 63 (for 4a and 4b, respectively). Also, an acid treatment of a mixture of 7a and 7b (90 to 10 ratio) in methanol resulted in a formation of a mixture of 7a and 7b (63 to 37 ratio) [11].
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15
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0042029028
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note
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Electrolysis of 1j at rt afforded 3j (57% ee). This lower ee of 3j than when the reaction was performed at -30 °C (80% ee) indicated that the facial selectivity was dependent on temperature.
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16
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0043030780
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