Association between elevated serum hepatic enzyme activity and total body fat in obese humans

Annals of Clinical and Laboratory Science

Volumn 33, Issue 3, 2003, Pages 257-264

  Choi, Jong Weon ^a,b  

^a Inha University School of Medicine   (South Korea)

^b Inha University Hospital   (South Korea)

Author keywords

Fatty liver; Obesity; Serum hepatic enzymes; Total body fat

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; GAMMA GLUTAMYLTRANSFERASE; LACTATE DEHYDROGENASE; LIVER ENZYME;

ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY FAT; BODY MASS; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVITY; ENZYME ASSAY; FATTY LIVER; FEMALE; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HUMAN; LACTATE DEHYDROGENASE BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; OBESITY; PRIORITY JOURNAL; SPECTROPHOTOMETRY;

ADULT; AGED; ALANINE TRANSAMINASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASES; BODY COMPOSITION; BODY MASS INDEX; FEMALE; GAMMA-GLUTAMYLTRANSFERASE; HUMANS; L-LACTATE DEHYDROGENASE; LIVER; MALE; MIDDLE AGED; OBESITY; TRANSAMINASES;

EID: 0041440206     PISSN: 00917370     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Pincus MR, Zimmerman HJ, Henry JB. Clinical enzymology. In: Clinical Diagnosis and Management by Laboratory Methods, 19th ed (Henry JB, Nakamura RM, Pincus MR, Woods GL, Bylund DJ, Fox HS, Stass SA, Eds), Saunders Co, Philadelphia, 1996, pp 268-295.
2. Panteghini M, Falsetti F, Chiari E, Malchiodi A. Determination of aspartate aminotransferase isoenzymes in hepatic diseases. Clin Chim Acta 1983;128:133-140.
3. Lean ME. Pathophysiology of obesity. Proc Nutr Soc 2000;59:331-336.
4. Kissebah AH, Freedman DS, Peiris AN. Health risks of obesity. Med Clin North Am 1989;73:111-138.
5. Luyckx FH, Desaive C, Thiry A, Dewe W, Scheen AJ, Gielen JE, Lefebvre PJ. Liver abnormalities in severely obese subjects: effect of drastic weight loss after gastroplasty. Int J Obes Relat Metab Disord 1998;22:222-226.
6. Golik A, Rubio A, Weintraub M, Byrne L. Elevated serum liver enzymes in obesity: a dilemma during clinical trials. Int J Obes 1991;15:797-801.
7. Bruckert E, Giral P, Ratziu V, Poynard T, Chapman MJ, Opolon P, Turpin G. A constellation of cardiovascular risk factors is associated with hepatic enzyme elevation in hyperlipidemic patients. Metabolism 2002;51:1071-1076.
8. Choi JW, Pai SH, Kim SK. Associations between total body fat and serum lipid concentrations in obese human adolescents. Ann Clin Lab Sci 2002;32:271-278.
9. Hurst PL, Langford NJ, Shue J. Reference intervals for plasma alanine aminopeptidase in the Hitachi 737 analyzer, derived from patients with normal biochemical liver profiles. Clin Chem 1988;34:2583-2584.
10. Jimenez A, Arenas J, Santos I, Martinez A. Aspartate aminotransferase and alanine aminotransferase double kinetic assay in a single channel of the Hitachi 705 analyzer. Clin Chem 1986;32:897-898.
11. Tozawa T, Hashimoto M. Influences of uncommon isoenzymes on determination of alkaline phosphatase activity by dry-chemistry analyzers. Rinsho Byori 2001; 49:389-394.
12. Jilg W, Schmidt M, Deinhardt F. Immune response to hepatitis B revaccination. J Med Virol 1988;24:377-384.
13. Donahue JG, Munoz A, Ness PM, Brown DE Jr, Yawn DH, McAllister HA Jr, Reitz BA, Nelson KE. The declining risk of post-transfusion hepatitis C virus infection. N Engl J Med 1992;327:369-373.
14. Jebb SA, Cole TJ, Doman D, Murgatroyd PR, Prentice AM. Evaluation of the novel Tanita body-fat analyzer to measure body composition by comparison with a four-compartment model. Br J Nutr 2000;83:115-122.
15. Choo V. WHO reassesses appropriate body-mass index for Asian populations. Lancet 2002;360:235.
16. Burns CJ, Boswell JM, Olsen GW. Liver enzyme activity and body mass index. J Occup Environ Med 1996;38: 1248-1252.
17. Robinson D, Whitehead TP. Effect of body mass and other factors on serum liver enzyme levels in men attending for well population screening. Ann Clin Biochem 1989;26: 393-400.
18. Mala H, Zadak Z, Sobotka L, Maly J. Changes in selected biochemical parameters during a low-calorie reducing diet. Sb Lek 2000;101:105-108.
19. Fishbein H, Miner DM, Mogren DC, Chalekson Dd D. The spectrum of fatty liver in obese children and the relationship of serum aminotransferases to severity of steatosis. J Pediatr Gastroenterol Nutr 2003;36:54-61.
20. Guzzaloni G, Grugni G, Minocci A, Moro D, Morabito F. Liver steatosis in juvenile obesity: correlations with lipid profile, hepatic biochemical parameters and glycemic and insulinemic responses to an oral glucose tolerance test. Int J Obes Relat Metab Disord 2000;24:772-776.