Effect of leptin on hypothalamic release of gnrh and neurotransmitter amino acids during sexual maturation in female rats

Experimental and Clinical Endocrinology and Diabetes

Volumn 111, Issue 5, 2003, Pages 274-277

  Reynoso, R ^a   Ponzo, O J ^a   Szwarcfarb, B ^a   Rondina, D ^a   Carbone, S ^a   Rimoldi, G ^a   Scacchi, P ^a,b   Moguilevsky, Jaime A ^a,b  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

Author keywords

Excitatory amino acids; GABA; GnRH; Leptin

Indexed keywords

4 AMINOBUTYRIC ACID; ASPARTIC ACID; EXCITATORY AMINO ACID; GLUTAMIC ACID; GONADORELIN; LEPTIN; N METHYL DEXTRO ASPARTIC ACID; NEUROTRANSMITTER;

4 AMINOBUTYRIC ACID RELEASE; ADIPOCYTE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; EVALUATION; FEMALE; GONADORELIN RELEASE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HORMONE ACTION; HYPOTHALAMUS; NEUROTRANSMISSION; NEUROTRANSMITTER RELEASE; NONHUMAN; PREPUBERTY; PRIORITY JOURNAL; PUBERTY; RADIOIMMUNOASSAY; RAT; SEXUAL MATURATION; SINGLE DRUG DOSE;

AMINO ACIDS; ANIMALS; FEMALE; GONADOTROPIN-RELEASING HORMONE; HYPOTHALAMUS; LEPTIN; NEUROTRANSMITTER AGENTS; RATS; RATS, WISTAR; SEXUAL MATURATION;

EID: 0041423519     PISSN: 09477349     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2003-41285     Document Type: Article

References (20)

1. Ahima RS, Dushay J, Flier SN, Prabakaran D, Flier JS. Leptin accelerates the onset of puberty in normal female mice. J Clin Invest 1997; 99: 391-395
2. Blum WF, Englaro P, Hanistsh S, Heinman ML, Birkett M, Hanastasio AM, Kiess W, Rascher W. Plasma leptin levels in children and adolescents: dependence on body mass index, body fat mass, gender, pubertal stage and testosierone. J Clin Endocrinol Metab 1997; 82: 2904-2910
3. Brann DW, Mahesh VB. Excitatory amino acid regulation of gonadotropin secretion: modulation by steroid hormones. J Steroid Biochem Mol Biol 1992; 41: 847-850
4. Carro E, Pinilla L, Seoane L, Considine R, Aguilar E, Casanueva F, Dieguez C. Influence of endogenous leptin tone on the estrous cycle and luteinizing hormone pulsatility in female rats. Neuroendocrinology 1997; 66: 375-377
5. Chehab FF, Mouzih K, Lu R, Lin ME. Early onset of reproductive function in normal female mice treated with leptin. Science 1997; 275: 88-90
6. Cheung CC, Thornton JE, Kuijper JL, Weigle DS, Clifton DK, Steiner RA. Leptin is a metabolic gate for the onset of puberty in the female rat. Endocrinology 1997; 138: 855-888
7. Conway GS, Jacobs HS. Leptin a hormone of reproduction. Human Reprod 1997; 12: 633-635
8. Demling J, Fuchs E, Baumert M, Wuttke W. Preoptic catecholamine, GABA, and glutamate release in ovariectomized and ovariectomized estrogen primed rats utilizing a pushpull cannula technique. Neuroendocrinology 1985; 41: 212-218
9. Feleder C, Ginzburg M, Wuttke W, Moguilevsl(y JA, Arias P. GABAergic activation inhibits the hypothalamic-pitutary ovaric axis and sexual development in the immature female rat. Associated changes in hypothalamic glutamatergic and taurinergic systems. Dev Brain Res 1999; 116: 151-157
10. Fuchs E, Mansky T, Stock K, Vijayan E, Wuttke W. Involvement of catecholamines and glutamate in GABAergic mechanisms regulatory to luteinizing hormone and prolactin secretion. Neuroendocrinology 1984; 38: 484-489
11. Jarry H, Hirsch B, Leonhardt, Wuttke W. Amino acid neurotransmitter release in the preoptic area of rats during the positive feedback actions of estradiol on LH release. Neuroendocrinology 1992; 56: 133-140
12. Kordon C, Drouva SV, Martinez de la Escalera G, Weiner R. Role of classic and peptides neuromediators in the neuroendocrine regulation of luteinizing hormone and prolactin. In: Knobil E, Neill JD (Eds.). The Physiology of Reproduction. Vol I. New York: Raven Press, 1994: 1621-1681
13. Lamberts R, Mansky T, Stock K, Vijayan E, Wuttke W. Involvement of preoptic-anterior hypothalamic GABA neurons in the regulation of pituitary LH and prolactin release. Exp Brain Res 1984; 52: 356-362
14. Moguilevsl(y JA, Wuttke W. Changes in the control of gonadotrophin secretion by neurotransmitters during sexual development in rats. Exp Clin Endocrinol Diabetes 2001; 109: 188-195
15. MoguilevskyjA, Carbone S, Szwarcfarb B, Rondina D, Scacchi P. Hypothalamic excitatory amino acid system during sexual maturation in female rats. J Steroid Biochem Mol Biol 1995; 53: 337-351
16. Moguilevsl(y JA, Carbone S, Szwarcfarb B, Rondina D. Sexual maturation modifies the GABAergic control of gonadotropin secretion in female rats. Brain Res 1991; 563: 12-20
17. Ojeda SR, Urbanski HF. Puberty in the rat. In: Knobill E, Neill JD (Eds.). The Physiology of Reproduction. Vol. II. New York: Raven Press, 1994: 363-409
18. Ponzo O, Szwarcfarb B, Rondina D, Carbone S, Reynoso R, Scacchi P. Changes in the sensitivity of gonadotrophin axis to leptin during sexual maturation in female rats. Neuroendocrinology Letters 2001; 22: 427-431
19. Tukey JW. Comparing individual means in the analysis of variance. Biometrics 1949; 5: 99-114
20. Yu WH, Kumura M, Walczewska A, l(aranth S, McCann SM. Role of leptin in hypothalamic-pituitary function. Proc Natl Acad Sci USA 1997; 94: 123-128