Grading of atypia in nevi: Correlation with melanoma risk

Modern Pathology

Volumn 16, Issue 8, 2003, Pages 764-771

  Arumi Uria, Montserrat ^a   McNutt, N Scott ^a   Finnerty, Bridget ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Atypia; Dysplastic nevus; Malignant melanoma

Indexed keywords

ARTICLE; CANCER GRADING; CANCER RISK; CELL NUCLEUS; CHILD; CHROMATIN CONDENSATION; CONTROLLED STUDY; CYTOARCHITECTURE; CYTOLOGY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MELANOCYTE; MELANOCYTIC NEVUS; MELANOMA; NEVUS; NUCLEOLUS; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SCORING SYSTEM; SEX RATIO; SKIN FIBROSIS; STAINING; STATISTICAL ANALYSIS;

ADOLESCENT; ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; DYSPLASTIC NEVUS SYNDROME; FEMALE; HUMANS; MALE; MELANOMA; MIDDLE AGED; ODDS RATIO; PRECANCEROUS CONDITIONS; RETROSPECTIVE STUDIES; RISK FACTORS; SKIN NEOPLASMS;

EID: 0041387338     PISSN: 08933952     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.MP.0000082394.91761.E5     Document Type: Article

References (42)

1. Arumi Uria M. Nevus displásico: gradación de la atipia y correlación de la atipia con marcadores de proliferación y de migración celular. Barcelona, Spain: Autonomous University of Barcelona; 2001.
2. Clark WH Jr, Reimer RR, Greene M, Ainsworth AM, Mastrangelo MJ. Origin of familial malignant melanomas from heritable melanocytic lesions. "The B-K mole syndrome." Arch Dermatol 1978;114:732-8.
3. Clark WH Jr. The dysplastic nevus syndrome. Arch Dermatol 1988;124:1207-10.
4. Clark WH Jr, Elder DE, Guerry DIV, Epstein MN, Greene MH, Van Horn M. A study of tumor progression: the precursor lesions of superficial spreading and nodular melanoma. Hum Pathol 1984;15:1147-65.
5. Elder DE, Goldman LI, Goldman SC, Greene MH, Clark WH Jr. Dysplastic nevus syndrome: a phenotypic association of sporadic cutaneous melanoma. Cancer 1980;46:1787-94.
6. Reed RJ, Clark WH Jr, Mihm MC. Premalignant melanocytic dysplasias. In: Ackerman AB, editor. Pathology of malignant melanoma. New York: Masson; 1981. p. 159-83.
7. Greene MH, Clark WH Jr, Tucker MA, Elder DE, Kraemer KH, Guerry DIV, et al. Acquired precursors of cutaneous malignant melanoma. The familial dysplastic nevus syndrome. N Engl J Med 1985;312:91-7.
8. Clark WH Jr, Elder DE, Guerry DPIV. Dysplastic nevi and malignant melanoma. In: Farmer ER, Hood AF, editors. Pathology of the skin. 1st ed. East Norwalk, CT: Appleton and Lange; 1990. p. 684-756.
9. Elder DE, Greene MH, Bondi EE, Clark WH Jr. Acquired melanocytic nevi and melanoma. The dysplastic nevus syndrome. In: Ackerman AB, editor. Pathology of malignant melanoma. New York: Masson; 1981. p. 185-215.
10. Halpern AC, Guerry DI, Elder DE, Clark WH Jr, Synnestvedt M, Norman S, et al. Dysplastic nevi as risk markers of sporadic (nonfamilial) melanoma. Arch Dermatol 1991;127:995-9.
11. Elder DE, Murphy GF. Melanocytic tumors of the skin. Atlas of tumor pathology. 3rd series. Fascicle 2. Washington, D.C.: Armed Forces Institute of Pathology; 1991.
12. Mihm MC Jr, Googe PB. Problematic pigmented lesions. A case method approach. 1st ed. Philadelphia: Lea and Febiger; 1990.
13. Kelly JW, Crutcher WA, Sagebiel RW. Clinical diagnosis of dysplastic melanocytic nevi. A clinicopathologic correlation. J Am Acad Dermatol 1986;14:1044-52.
14. Roth ME, Grant-Kels JM, Ackerman AB, Elder DE, Friedman RJ, Heilman ER, et al. The histopathology of dysplastic nevi. Continued controversy. Am J Dermatopathol 1991;13:38-51.
15. Sagebiel RW. The dysplastic melanocytic nevus. J Am Acad Dermatol 1989;20:496-501.
16. Holly EA, Kelly JW, Shpall SN, Chiu S-H. Number of melanocytic nevi as a major risk factor for malignant melanoma. J Am Acad Dermatol 1987;17:459-68.
17. Piepkorn MW, Barnhill RL, Cannon-Albright LA, Elder DE, Goldgar DE, Lewis CM, et al. A multiobserver, population-based analysis of histologic dysplasia in melanocytic nevi. J Am Acad Dermatol 1994;30:707-14.
18. Freinkel RK, Cage GW, Caro WA, Carter DM, Cole P, Elston RC, et al. Consensus Conference. Precursors to malignant melanoma. JAMA 1984;251:1864-6.
19. NIH Consensus Development Panel on Early Melanoma. NIH Consensus Conference: diagnosis and treatment of early melanoma. JAMA 1992;268:1314-9.
20. Carey WP Jr, Thompson CJ, Synnestvedt M, Guerry DIV, Halpern A, Schultz D, et al. Dysplastic nevi as a melanoma risk factor in patients with familial melanoma. Cancer 1994;74:3118-25.
21. Crutcher WA, Sagebiel RW. Prevalence of dysplastic naevi in a community practice [letter]. Lancet 1984;1:729.
22. Tong AKF, Murphy GF, Mihm MC Jr. Dysplastic nevus: a formal histogenetic precursor of malignant melanoma. In: Mihm MC Jr, Murphy GF, Kaufman N, editors. Pathobiology and recognition of malignant melanoma. Baltimore, MD: Williams and Wilkins; 1988. p. 10-8.
23. Rhodes AR, Mihm MC Jr, Weinstock MA. Dysplastic melanocytic nevi: a reproducible histologic definition emphasizing cellular morphology. Mod Pathol 1989;2:306-19.
24. Crowson AN, Magro CM, Mihm MC Jr. The melanocytic proliferations. 1st ed. New York: Wiley; 2001.
25. Kurman RJ, Norris HJ, Wilkinson EJ. Tumors of the cervix, vagina and vulva. Atlas of tumor pathology. 3rd series. Fascicle 4. Washington, D.C.: Armed Forces Institute of Pathology; 1992.
26. McKee PH. Pathology of the skin, with clinical correlations. 2nd ed. London: Times Mirror International; 1996.
27. Clark WH Jr, From L, Bernadino EA, Mihm MC Jr. The histogenesis and biologic behavior of primary human malignant melanomas of the skin. Cancer Res 1969;29:705-15.
28. Breslow A. Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma. Ann Surg 1970;172:902-8.
29. Clark WH Jr, Elder DE, Guerry DPIV, Braitman LE, Trock BJ, Schultz D, et al. Model predicting survival in stage I melanoma based on tumor progression. J Natl Cancer Inst 1989;81:1893-904.
30. Sagebiel RW. Problems in microstaging of melanoma vertical growth. In: Mihm MC Jr, Murphy GF, Kaufman N, editors. Pathobiology and recognition of malignant melanoma. Baltimore, MD: Williams and Wilkins; 1988. p. 94-109.
31. Barnhill RL, Roush GC, Duray PH. Correlation of histologic architectural and cytoplasmic features with nuclear atypia in atypical (dysplastic) nevomelanocytic nevi. Hum Pathol 1990;21:51-8.
32. Duncan LM, Berwick M, Bruijn JA, Byers R, Mihm MC, Barnhill RL. Histopathologic recognition and grading of dysplastic melanocytic nevi: an interobserver agreement study. J Invest Dermatol 1993;100 (3 Suppl):318-21.
33. Shea CR, Vollmer RT, Prieto VG. Correlating architectural disorder and cytologic atypia in Clark (dysplastic) melanocytic nevi. Hum Pathol 1999;30:500-5.
34. Barnhill RL. Melanocytic proliferations with architectural disorder and cytologic atypia (melanocytic dysplasia and dysplastic nevi). In: Barnhill RL, Busam KJ, editors. Pathology of melanocytic nevi and malignant melanoma. 1st ed. Boston: Butterworth-Heinemann; 1995. p. 169-94.
35. Ackerman AB. Critical commentary on statements in "Precursors to Malignant Melanoma." Am J Dermatopathol 1984;6(Suppl 1):181-3.
36. Barnhill RL. Current status of the dysplastic melanocytic nevus. J Cutan Pathol 1991;18:147-59.
37. Bergman W, Ruiter DJ, Scheffer E, van Vloten WA. Melanocytic atypia in dysplastic nevi. Immunohistochemical and cytophotometrical analysis. Cancer 1988;61:1660-6.
38. Black WC, Hunt WC. Histologic correlations with the clinical diagnosis of dysplastic nevus. Am J Surg Pathol 1990;14:44-52.
39. Ahmed I, Piepkorn MW, Rabkin MS, Meyer LJ, Feldkamp M, Goldgar DE, et al. Histopathologic characteristics of dysplastic nevi. J Am Acad Dermatol 1990;22:727-33.
40. Sagebiel RW, Banda PW, Schneider JS, Crutcher WA. Age distribution and histologic patterns of dysplastic nevi. J Am Acad Dermatol 1985;13:975-82.
41. Schmidt B, Weinberg DS, Hollister K, Barnhill RL. Analysis of melanocytic lesions by DNA image cytometry. Cancer 1994;73:2971-7.
42. Kang S, Barnhill RL, Mihm MC Jr, Fitzpatrick TB, Sober AJ. Melanoma risk in individuals with clinically atypical nevi. Arch Dermatol 1994;130:999-1001.