Ca2+ signalling in brain synaptosomes activated by dinucleotides

Journal of Membrane Biology

Volumn 194, Issue 1, 2003, Pages 1-10

  Miras Portugal, M T ^a   Pintor, J ^a   Gualix, J ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Ap4A; Ap5A; Diadenosine polyphosphates; Purinergic receptors; Voltage dependent calcium channels

Indexed keywords

4 AMINOBUTYRIC ACID; ACETYLCHOLINE; CALCIUM; CALCIUM CHANNEL; DIADENOSINE HEXAPHOSPHATE; DIADENOSINE PENTAPHOSPHATE; DIADENOSINE POLYPHOSPHATE; DIADENOSINE TETRAPHOSPHATE; DINUCLEOTIDE; GLUTAMIC ACID; PURINE RECEPTOR; DIADENOSINE 5',5'''' P1,P6 HEXAPHOSPHATE; DIADENOSINE 5',5''''-P1,P6-HEXAPHOSPHATE; DINUCLEOSIDE PHOSPHATE; PURINE P2 RECEPTOR;

ANIMAL TISSUE; BRAIN SYNAPTOSOME; CALCIUM SIGNALING; CATION TRANSPORT; CHANNEL GATING; DEPOLARIZATION; NERVE ENDING; NONHUMAN; RAT; REVIEW; SYNAPSE VESICLE; ANIMAL; BRAIN; DRUG EFFECT; HUMAN; PHYSIOLOGY; SYNAPTOSOME;

ANIMALIA;

ANIMALS; BRAIN; CALCIUM SIGNALING; DINUCLEOSIDE PHOSPHATES; HUMANS; RECEPTORS, PURINERGIC P2; SYNAPTOSOMES;

EID: 0041384118     PISSN: 00222631     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00232-003-2024-x     Document Type: Review

References (54)

1. 4-tetraphosphate binding subunit from a multiprotein of HeLa cell DMA polymerase α. Proc. Natl. Acad. Sci. USA 80:4931-4935
2. 3-triphosphate hydrolase. Biochemistry 35:11529-11535
3. Brenner, C., Bieganowski, P., Pace, H.C., Huebner, K. 1999. The histidine triade superfamily of nucleotide binding proteins. J. Cell Physiol. 181:179-187
4. 4 receptors. Eur. J. Pharmacol. 317:383-389
5. 2-diuridine 5′ pyrophosphates. J. Chem. Soc. 3:2947-2952
6. Díaz-Hernández, M., Pereira, M.F., Pintor, J., Cunha, R.A., Ribeiro, J.A., Miras-Portugal, M.T. 2002a. Modulation of the rat hippocampal dinucleotide receptor by adenosine receptor activation. J. Pharm. Exp. Ther. 301:441-450
7. Díaz-Hernández, M., Pintor, J., Castro, E., Miras-Portugal, M.T. 2001. Independent receptors for diadenosine pentaphosphate and ATP in rat midbrain single synaptic terminals. Eur. J. Neurosci. 14:918-926
8. Díaz-Hernández, M., Pintor, J., Castro, E., Miras-Portugal, M.T. 2002b. Co-localisation of functional nicotinic and ionotropic nucleotide receptors in isolated cholinergic synaptic terminals. Neuropharmacology 42:20-33
9. Díaz-Hernández, M., Pintor, J., Miras-Portugal, M.T. 2000. Modulation of the dinucleotide receptor present in rat midbrain synaptosomes by adenosine and ATP. Br. J. Pharmacol. 130:434-440
10. 4-diadenosine diguanosine 5′ tetraphosphate in brine shrimp eggs. J. Biol. Chem. 238:344-350
11. 4-tetraphosphate are present and releasable, but metabolically inactive in human platelets. Biochem. J. 208:737-742
12. i increase in rat basal ganglia aminergic terminals. J. Neurosci. Res. 64:174-182
13. Gómez-Villafuertes, R., Gualix, J., Miras-Portugal, M.T. 2001. Single GABAergic synaptic terminals from rat midbrain exhibit functional P2X and dinucleotide receptors, able to induce GABA secretion. J. Neurochem. 77:84-93
14. 4-tetraphosphate triggers initiation of in vitro DNA replication in baby hamster kidney cells. Proc. Natl. Acad. Sci. USA 75:371-375
15. Gualix, J., Fideu, M.D., Pintor, J., Rotllán, P., García-Carmona, F., Miras-Portugal, M.T. 1997. Characterization of diadenosine polyphosphate transport into chromaffin granules from adrenal medulla. FASEB J. 11:981-990
16. Gualix, J., Pintor, J., Miras-Portugal. M.T. 1999. Characterization of nucleotide transport into rat brain synaptic vesicles. J. Neurochem. 73:1098-1104
17. Harrison, M.J., Brossmer, R., Goody, R.S. 1975. Inhibition of platelet aggregation and the platelet release reaction by α,ω-diadenosine polyphosphates. FEBS Lett. 54:57-60
18. 4-diadenosine 5′ tetraphosphate induces nitric oxide release from bovine aortic endothelial cells. FEBS Lett. 427:320-324
19. 4-tetraphophate. J. Biol. Chem. 266:6915-6918
20. Huebner, K., Sozzi, G., Brenner, C., Pierotti, M.A., Croce, C.M. 1999. Fhit loss in lung cancer: diagnostic and therapeutic implications. Adv. Oncol. 15:3-10
21. Hugel, S., Schlichter, R. 2000. Presynaptic P2X receptors facilitate inhibitory GABAergic transmission between cultured rat spinal cord dorsal horn neurons. J. Neurosci. 20:2121-2130
22. Inoue K., Koizumi, S., Ueno, S., Kita, A., Tsuda, M. 1999. The functions of ATP receptors in the synaptic transmission in the hippocampus. Prog. Brain Res. 120:193-206
23. Israel, M., Lesbats, B. 1981. Chemiluminescent determination of acetylcholine, and continuous detection of its release from Torpedo electric organ synapses and synaptosomes. Neurochem. Int. 3:81-90
24. Jo, Y.H., Schlichter, R. 1999. Synaptic co-release of ATP and GABA in cultured spinal neurons. Nat. Neurosci. 2:241-245
25. Lazarowski, E.R., Watt, W.C., Stutts, M.J., Boucher, R.C., Harden, T.K. 1995. Pharmacological selectivity of the cloned human P2U-purinoceptor: potent activation by diadenosine tetraphosphate. Br. J. Pharmacol. 116:1619-1627
26. 3A) in human platelets. Biochem. Biophys. Res. Commun. 115:253-260
27. 3A) Mediates human platelet aggregation by liberation of ADP. Biochem. Bioph. Res. Commun. 118:704-709
28. 4A and Other Dinucleoside Polyphosphates. CRC Press, Boca Raton
29. McLennan, A.G., Barnes, L.D., Blackburn, G.M., Brenner, C., Guranowski, A., Miller, A.D., Rovira, J.M., Rotllan, P., Soria, B., Tanner, J.A., Sillero, A. 2001. Recent progress in the study of the intracellular functions of diadenosine polyphosphates. Drug Develop. Res. 52:249-259
30. Meir, A., Ginsburg, S., Butkevich, A., Kachalsky, S.G., Kaiserman, I., Ahdut, R., Demirgoren, S., Rahamimoff, R. 1999. Ion channels in presynaptic nerve terminals and control of transmitter release. Physiol. Rev. 79:1019-1088
31. Pintor, J., Díaz-Hernández, M., Bustamante, C., Gualix, J., Gomez de Terreros, F.J., Miras-Portugal, M.T. 1999. Presence of dinucleotide and ATP receptors in human cerebrocortical synaptic terminals. Eur. J. Pharmacol. 366:159-165
32. Pintor, J., Díaz-Hernández, M., Gualix, J., Gómez-Villafuertes, R., Hernando, F., Miras-Portugal, M.T. 2000. Diadenosine polyphosphate receptors from rat and guinea-pig brain to human nervous system. Pharmacol. Ther. 87:103-115
33. 2+ dependent release evoked by 4-aminopyridine and veratridine. Neurosci. Lett. 136:141-144
34. Pintor, J., Gómez-Villafuertes, R., Miras-Portugal, M.T. 2001. Pharmacological profile of the dinucleotide receptor present in rat brain isolated synaptic terminals. Anal. Pharmacol. 2:85-92
35. Pintor, J., Gualix, J., Miras-portugal, M.T. 1997a. Diinosine polyphosphates, a group of dinucleotides with antagonistic effects on diadenosine polyphosphate receptor. Mol. Pharmacol. 51:277-284
36. Pintor, J., Gualix, J., Miras-Portugal, M.T. 1997b. Dinucleotide receptor modulation by protein kinases (protein kinases A and C) and protein phosphatases in rat brain synaptic terminals. J. Neurochem. 68:2552-2557
37. 1 purinoceptors. Br. J. Pharmacol. 51:277-284
38. Pintor, J., Miras-Portugal, M.T. 1995. A novel receptor for diadenosine polyphosphates coupled to calcium increase in rat brain synaptosomes. Br. J. Pharmacol. 115:895-902
39. 4 and dinucleotide receptors: are there too many? Trends Pharmacol. Sci. 21:135
40. 5A - from caudate putamen of conscious rats. Neurosci. Lett. 150:13-16
41. Pintor, J., Porras, A., Mora, F., Miras-Portugal M.T. 1995. Dopamine receptor blockade inhibits the amphetamine-induced release of diadenosine tetraphosphate and diadenosine pentaphosphate, from neostriatum of the conscious rat. J. Neurochem. 64:670-676
42. 2+ transients in guinea-pig brain via receptors distinct from those for ATP. J. Physiol. 504:327-335
43. Pintor, J., Rotllán, P., Torres, M., Miras-Portugal, M.T. 1992b. Characterization and quantification of diadenosine hexaphosphate in chromaffin cells: granular storage and secretagogue-induced release. Anal. Biochem. 200:296-300
44. 4A) binding sites in cultured chromaffin cells: evidence for a P2Y site. Brit. J. Pharmacol. 103:1980-1984
45. 5A - from perfused bovine adrenal medulla and isolated chromaffin cells. Life Sci. 48:2317-2324
46. 2+ influx distinct from ATP-mediated influx. J. Neurosci, Res. 44:478-489
47. 4A) in mammalian cells in levels varying widely with proliferative activity of the tissue: a possible positive "pleiotypic activator". Proc. Natl. Acad. Sci. USA 73:3984-3988
48. 5A - in bovine adrenal medulla: presence in chromaffin granules. J. Neurochem. 51:1696-1703
49. 1-purinoceptor. Br. J. Pharmacol. 118:167-173
50. Schlüter, H., Offers, E., Brüggemann, G., van der Giet, M., Tepel, M., Nordhoff, E., Karas, M., Spieker, C., Witzel, H., Zidek, W. 1994. Diadenosine phosphates and the physiological control of blood pressure. Nature 367:186-188
51. Walkowiak, B., Baraniak, J., Cierniewski, C.S., Stec, W. 2002. Inhibition of ADP-triggered blood platelet aggregation by diadenosine polyphosphate analogues. Bioorg. Med. Chem. Lett. 12:1959-1962
52. Wildman, S.S., Brown, S.G., King, B.F., Burnstock, G. 1999. Selectivity of diadenosine polyphosphates for rat P2X receptors subunits. Eur. J. Pharmacol. 367:119-123
53. Wonnancott, S. 1997. Presynaptic nicotinic ACh receptors. Trends Neurosci. 20:92-98
54. Zamecnik, P.C., Stephenson, M.L., Janeway, C.M., Randerath, K. 1966. Enzymatic synthesis of diadenosine tetraphosphate and diadenosine triphosphate with a purified lysyl-sRNA synthetase. Biochem. Biophys. Res. Commun. 24:91-97