Effects of the enantiomers of BayK 8644 on the charge movement of L-type Ca channels in guinea-pig ventricular myocytes

Journal of Membrane Biology

Volumn 193, Issue 3, 2003, Pages 215-227

  Artigas, P ^a   Ferreira, G ^b   Reyes, N ^b   Brum, G ^b   Pizarro, G ^a,b  

^a UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^b DEPARTAMENTO DE BIOQUÍMICA   (Uruguay)

Author keywords

Cardiac myocytes; Charge movement; Dihydropyridines; Gating currents; L type Ca channel; Voltage dependent inactivation

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL STIMULATING AGENT;

AGONIST; ANIMAL; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM CONDUCTANCE; CELL CULTURE; CELL MEMBRANE CONDUCTANCE; CELL MEMBRANE POTENTIAL; CHANNEL GATING; CHEMISTRY; COMPARATIVE STUDY; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ELECTRICITY; ENANTIOMER; GUINEA PIG; HEART MUSCLE CELL; HEART VENTRICLE; ISOMERISM; NONHUMAN; PHYSIOLOGY; STEADY STATE; STRUCTURE ACTIVITY RELATION;

3-PYRIDINECARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-(2-(TRIFLUOROMETHYL)PHENYL)-, METHYL ESTER; ANIMALS; CALCIUM CHANNEL AGONISTS; CALCIUM CHANNELS, L-TYPE; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROSTATICS; GUINEA PIGS; HEART VENTRICLES; ION CHANNEL GATING; ISOMERISM; MEMBRANE POTENTIALS; MYOCYTES, CARDIAC; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 0041384018     PISSN: 00222631     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00232-003-2020-1     Document Type: Article

References (29)

1. Bean, B.P. 1984. Nitrendipine block of cardiac calcium channels: high-affinity binding to the inactivated state. Proc. Natl. Acad. Sci. USA 81:6388-6392
2. Bean, B.P., Ríos, E. 1989. Nonlinear charge movement in mammalian cardiac ventricular cells. Components from Na and Ca channel gating. J. Gen. Physiol. 94:65-93
3. 2+ channels. Trends Pharmacol. Sci. 9:257-261
4. Bezanilla, F., Taylor, R.E., Fernandez, J.M. 1982. Distribution and kinetics of membrane dielectric polarization. I. Long-term inactivation of gating currents. J. Gen. Physiol. 79:21-40
5. Brum, G., Ríos, E. 1987. Intramembrane charge movement in skeletal muscle fibers. Properties of charge 2. J. Physiol. 387:489-517
6. Brum, G., Fitts, R., Pizarro, G., Ríos, E. 1988. Voltage sensors of the frog skeletal muscle membrane require calcium to function in excitation-contraction coupling. J. Physiol. 398:475-505
7. 2+ channels in cardiac myocytes. Naunyn Schmiedebergs Arch. Pharmacol. 361:465-476
8. Ferreira, G., Artigas, P., Pizarro, G., Brum, G. 1997. Butanedione monoxime promotes voltage-dependent inactivation of Ca channels in heart: Effects on gating currents. J. Mol. Cell. Cardiol. 29:777-787
9. Grabner, M., Wang, Z., Hering, S., Striessnig, J., Glossman, H. 1996. Transfer of 1,4-dihydropyridine sensitivity from L-type to class A (BI) calcium channels. Neuron. 16:207-218
10. 2+ channel gating current. Am. J. Physiol. 262:H472-H477
11. Hadley, R.W., Hume, J.R. 1987. An intrinsic potential-dependent inactivation mechanism associated with calcium channels in guinea-pig myocytes. J. Physiol. 389:205-222
12. Hamilton, S.L., Yatani, A., Brusch, K., Schwartz, A., Brown, A.M. 1987. A comparison between the binding and electrophysiological effects of dihydropyridines on cardiac membranes. Mol. Pharmacol. 31:221-231
13. Hamill, O.P., Marty, A., Neher, E., Sakmann, B. 1981. Improved patch-clamp techniques for high resolution current recording from cells and cell free membrane patches. Pfluegers. Arch. 391:85-100
14. Hering, S., Hughes, A.D., Timin, E.N., Bolton, T.B. 1993. Modulation of calcium channels in arterial smooth muscle cells by dihydropyridine enantiomers. J. Gen. Physiol. 101:393-410
15. 2+ channel gating behavior favored by dihydropyridine Ca agonist and antagonist. Nature 311:536-544
16. Hille, B. 1977. Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. J. Gen. Physiol. 69:497-515
17. 2+ channel gating charge by the dihydropyridine agonist BayK 8644. Biophys. J. 58:1307-1311
18. Kamp, T., Sanguinetti, M.C., Miller, R.J. 1989. Voltage- and use-dependent modulation of cardiac calcium channels by dihydropyridine (+) 202-791. Circ. Research. 69:338-351
19. Kass, R.S. 1987. Voltage-dependent modulation of cardiac calcium channel current by optical isomers of Bay K 8644: Implications for channel gating. Circ. Research 61:11-15
20. Lacerda, A.E., Brown, A.M. 1989. Non-modal gating of cardiac calcium channels as revealed by dihydropyridines. J. Gen. Physiol. 93:1243-1273
21. Lory, P., Rassendren, F.A., Richard, S., Tiaho, F., Nargeot, J. 1990. Characterization of voltage-dependent calcium channels expressed in Xenopus oocytes injected with mRNA from rat heart. J. Physiol. 429:95-112
22. Markwardt, F., Nilius, B. 1988. Modulation of calcium channel currents in guinea-pig single ventricular heart cells by the dihydropyridine Bay K 8644. J. Physiol. 399:559-575
23. Mc Donald, T.F., Pelzer, S., Trautwein, W., Pelzer, D. 1994. Regulation and modulation of calcium channels in cardiac, skeletal and smooth muscle cells. Physiol. Rev. 74:365-507
24. 2+ channels. J. Gen. Physiol. 111:463-471
25. Reuter, H., Porzig, H., Kokubun, S., Prod'hom, B. 1988. Calcium channels in the heart. Properties and modulation by dihydropyridine enantiomers. Ann. N. Y. Acad. Sci. 522:16-24
26. Sanguinetti, M.C., Kass, R.S. 1984. Voltage-dependent block of calcium channel current in the calf cardiac Purkinje fiber by dihydropyridine calcium channel antagonists. Circ. Res. 55:336-348
27. Sanguinetti, M.C., Krafte, D.S., Kass, R.S. 1986. Bay K8644: Voltage-dependent modulation of Ca channel current in heart cells. J. Gen. Physiol. 88:369-392
28. Shirokov, R., Levis, R., Shirokova, N., Ríos, E. 1992. Two classes of gating charge from L-type calcium channels in guinea pig ventricular cells. J. Gen. Physiol. 99:863-895
29. 2+ channel antagonist and activators in cultured neonatal rat ventricular myocytes. Mol. Pharmacology 35:541-552