The synthesis of 6-trifluoroethyl-L-lysine: A method to introduce functionality at C-6 of L-lysine

Tetrahedron Letters

Volumn 44, Issue 39, 2003, Pages 7345-7347

  Hallinan, E Ann ^a,b   Dorn, Clifford R ^a   Moore, William M ^a   Jerome, Gina M ^a   Manning, Pamela T ^a   Pitzele, Barnett S ^a  

^a PFIZER INC   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 TRIFLUOROETHYLLYSINE; LYSINE DERIVATIVE; NITRIC OXIDE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

EID: 0041379703     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2003.07.001     Document Type: Article

References (13)

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2. Moore W.M., Webber R.K., Jerome G.M., Tjoeng F.S., Misko T.P., Currie M.G. J. Med. Chem. 37:1994;3886-3888.
3. Mayer B., Hemmens B. Trends Biochem. Sci. 22:1997;477-481.
4. Hobbs A.J., Higgs A., Moncada S. Annu. Rev. Pharmacol. Toxicol. 39:1999;191-220.
5. Hallinan et al., submitted for publication.
6. McLaren A.D., Knight C.A. J. Am. Chem. Soc. 73:1951;4478-4479.
7. Advanced ChemTech, Louisville, KY, USA.
8. Funabiki K., Matsunaga K., Nojiri M., Hashimoto W., Yamamoto H., Shibata K., Matsui M. J. Org. Chem. 68:2003;2853-2860. and references cited therein.
9. 3Si (582.72): C, 59.77; H, 7.08; N, 4.60. Found: C, 59.59; H, 7.18; N, 4.60.
10. 2O (330.05): C, 29.11; H, 5.99; N, 8.49. Found: C, 29.49; H, 5.65; N, 8.19.
11. Hallinan E.A., Tsymbalov S., Dorn C.R., Pitzele B.S., Hansen D.W. Jr., Moore W.M., Jerome G.M., Connor J.R., Branson L.F., Widomski D.L., Zhang Y., Currie M.G., Manning P.T. J. Med. Chem. 45:2002;1686-1689.
12. 2O (360.20): C, 33.35; H, 6.16; N, 11.67. Found: C, 33.46; H, 5.99; N, 11.33.
13. Moore W.M., Webber R.K., Fok K.F., Jerome G.M., Connor J.R., Manning P.T., Wyatt P.S., Misko T.P., Tjoeng F.S., Currie M.G. J. Med. Chem. 39:1996;669-672.