Neuronal nuclear antigen (NeuN): A new tool in the diagnosis of central neurocytoma

Pathology Research and Practice

Volumn 199, Issue 7, 2003, Pages 463-468

  Soylemezoglu, Figen ^a   Onder, Sevgen ^a   Tezel, Gaye Guler ^a   Berker, Mustafa ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

Author keywords

Central neurocytoma; Immunohistochemistry; MAP2; NeuN; Oligodendroglioma

Indexed keywords

CELL NUCLEUS ANTIGEN; GLIAL FIBRILLARY ACIDIC PROTEIN; MICROTUBULE ASSOCIATED PROTEIN 2; MONOCLONAL ANTIBODY; NEURON SPECIFIC ENOLASE; NEURONAL NUCLEAR ANTIGEN; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ANTIBODY LABELING; ARTICLE; CELL NUCLEUS; CELL ULTRASTRUCTURE; CENTRAL NERVOUS SYSTEM TUMOR; CLEAR CELL CARCINOMA; CLINICAL ARTICLE; CONTROLLED STUDY; DIFFERENTIAL DIAGNOSIS; EPENDYMOMA; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; NERVE CELL; NERVE CELL DIFFERENTIATION; NEUROEPITHELIOMA; OLIGODENDROGLIOMA; RELIABILITY; SENSITIVITY AND SPECIFICITY; TISSUE SECTION; TUMOR BIOPSY;

EID: 0041379678     PISSN: 03440338     EISSN: None     Source Type: Journal    
DOI: 10.1078/0344-0338-00446     Document Type: Article

References (26)

1. Blümcke I, Becker AJ, Normann S, et al. (2001) Distinct expression pattern of microtubule-associated protein-2 in human oligodendrogliomas and glial precursor lesions. J Neuropath Exp Neurol 60 (10): 984-993
2. Figarella-Branger D, Pellisier JF, Daumas-Duport C, et al. (1992) Central neurocytomas. Critical evaluation of a small-cell neuronal tumour. Am J Surg Pathol 16 (2): 97-109
3. Figarella-Branger D, Soylemezoglu F, Kleihues P, et al. (2000) Central neurocytoma. In: Kleihues P and Cavenee W (Eds) Pathology and genetics of tumours of the nervous system, pp 107-109. Oxford University Press, Lyon.
4. Goto S, Nagahiro S, Ushio S, Kitaoka M, Nishio S, Fukui M (1993) Immunocytochemical detection of calcineurin and microtubule-associated protein 2 in central neurocytoma. J Neurooncol 16: 19-24
5. Gultekin HS, Dalmau J, Graus Y, Posner JB, Rosenblum MK (1998) Anti-Hu immunolabeling as an index of neuronal differentiation in human brain tumours: a study of 112 central neuroepithelial neoplasms. Am J Surg Pathol 22: 195-200
6. Hassoun J, Gambarelli D, Grisoli F, et al. (1982) Central neurocytoma: an electron microscopic study of two cases. Acta Neuropathol 56: 151-156
7. Hassoun J, Soylemezoglu F, Gambarelli D, Figarella-Branger D, von Ammon K, Kleihues P (1993) Central neurocytoma: A Synopsis of clinical and histological features. Brain Pathol 3 (3): 297-306
8. Hessler RB, Lopes MB, Frankfurter A, Reidy J, VandenBerg SR (1992) Cytoskeletal immunohystochemistry of central neurocytomas. Am J Surg Pathol 16: 1031-1038
9. Leung SY, Ng HK (1996) The recently recognized tumours that may mimic oligodendroglioma: Central neurocytoma, dysembryoplastic neurepithelial tumour, and clear cell ependymoma. Adv Anat Pathol 3: 30-138
10. Miller DC, Koslow M, Budzilovich GN, Burstein DE (1990) Synaptophysin. a sensitive and specific marker for ganglion cells in central nervous system neoplasms. Hum Pathol 21: 271-276
11. Mullen RJ, Buck CR, Smith AM (1992) NeuN, a neuronal specific nuclear protein in vertebrates. Development 116: 201-211
12. Pahlman S, Esscher T, Nilsson K (1986) Expression of gamma-subunit of enolase, neuron-specific enolase, in human non-neuroendocrine tumours and derived cell lines. Lab Invest 54 (5): 554-560
13. Parker JR, Armstrong DL, Strother D, et al. (2001) Antineuronal nuclei immunohistochemical staining patterns in childhood ependymomas. J Child Neurol 16: 548-552
14. Quinn B (1998) Synaptophysin staining in normal brain. Importance for diagnosis of ganglioglioma. Am J Surg Pathol 22: 550-556
15. Riederer BM, Draberova E, Viklicky V, Draber P (1995) Changes of MAP2 phosphorylation during brain development. J Histochem Cytochem 43: 1269-1284
16. Sarnat HB, Nochlin D, Born DE (1998) Neuronal nuclear antigen (NeuN): a marker of neuronal maturation in the early human fetal nervous system. Brain Dev 20 (2): 88-94
17. Shafit-Zagardo B, Davies P, Rockwood J, Kress Y, Lee SC (2000) Novel microtubule-associated protein-2 isoform is expressed early in human oligodendrocyte maturation. Glia 29: 233-245
18. Schild SE, Scheithauer BW, Haddock MG, et al. (1997) Central neurocytomas. Cancer 79: 790-795
19. Smith TW, Nikulasson S, De Girolami U, De Gennaro LJ (1993) Immunohistochemistry of synapsin I and synaptophysin in human nervous system and neuroendocrine tumours. Clin Neuropathol 12: 335-342
20. Soylemezoglu F, Scheithauer BW, Esteve J, Kleihues P (1997) Atypical central neurocytoma. J Neuropath Exp Neurol 56: 551-556
21. Tsuchida T, Matsumoto M, Shirayama Y, Imahori T, Kasai H, Kawamoto K (1996) Neuronal and glial characteristics of central neurocytoma: electron microscopical analysis of two cases. Acta Neuropathol 91: 573-577
22. von Deimling A, Janzer R, Kleihues P, Wiestler OD (1990) Patterns of differentiation in central neurocytoma - an immunohistochemical study of eleven biopsies. Acta Neuropathol (Berl) 79: 473-479
23. von Deimling A, Kleihues P, Saremaslani P, et al. (1991) Histogenesis and differentiation potential of central neurocytomas. Lab Invest 64: 585-591
24. Wharton SB, Chan KK, Hamilton FA, Anderson JR (1998) Expression of neuronal markers in oligodendrogliomas: an immunohistochemical study. Neuropathol Appl Neurobiol 24: 302-308
25. Wolf HK, Buslei R, Blümcke I, Wiestler OD, Pietsch T (1997) Neural antigens in oligodendrogliomas and dysembryoplastic neuroepithelial tumours. Acta Neuropathol 94: 436-443
26. Wolf HK, Buslei R, Schmidt-Kastner R, et al. (1996) NeuN: a useful neuronal marker for dignostic histopathology. J Histochem Cytochem 44: 1167-1171