Interactions between transhydrogenase and thio-nicotinamide analogues of NAD(H) and NADP(H) underline the importance of nucleotide conformational changes in coupling to proton translocation

Journal of Biological Chemistry

Volumn 278, Issue 35, 2003, Pages 33208-33216

  Singh, Avtar ^a   Venning, Jamie D ^a   Quirk, Philip G ^a   Van Boxel, Gijs I ^a   Rodrigues, Daniel J ^a   White, Scott A ^a   Jackson, J Baz ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; BIOLOGICAL MEMBRANES; CONFORMATIONS; CRYSTAL STRUCTURE; ENZYMES; GROUND STATE; PROTONS;

NUCLEOTIDES;

CHEMICAL REACTIONS;

3 CARBOTHIAMIDE DERIVATIVE; AMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) TRANSHYDROGENASE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; NICOTINAMIDE DERIVATIVE; NUCLEOTIDE BINDING PROTEIN; NUCLEOTIDE DERIVATIVE; PYRIDINE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SULFUR; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL MEMBRANE; BINDING KINETICS; BINDING SITE; CHEMICAL BOND; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE; MEMBRANE TRANSPORT; MITOCHONDRIAL MEMBRANE; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTON TRANSPORT; REDUCTION; ROTATION; STRUCTURE ANALYSIS; TECHNIQUE;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; KINETICS; MODELS, BIOLOGICAL; MODELS, CHEMICAL; NAD; NADP; NADP TRANSHYDROGENASE; NIACINAMIDE; PROTEIN BINDING; PROTEIN CONFORMATION; TEMPERATURE;

BACTERIA (MICROORGANISMS);

EID: 0041355343     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M303061200     Document Type: Article

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