Optimization of an effervescent tablet formulation using a central composite design optimization of an effervescent tablet formulation containing spray dried L-leucine and polyethylene glycol 6000 as lubricants using a central composite design

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 46, Issue 1, 1998, Pages 85-94

  Rotthäuser, Bärbel ^a   Kraus, Gerolf ^b   Schmidt, Peter C ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Effervescent tablets; L Leucine; Lubrication; Optimization; Polyethylene glycol 6000; Rotatable central composite design; Spray drying

Indexed keywords

BICARBONATE; DIAMANT INSTANT SUGAR; LEUCINE; LUBRICATING AGENT; MACROGOL 6000; STEARIC ACID; SUCROSE; UNCLASSIFIED DRUG;

ARTICLE; COMPRESSION; CRUSHING STRENGTH; DRUG FORMULATION; EFFERVESCENT TABLET; HUMIDITY; STORAGE; TABLET COMPRESSION; TABLET DISINTEGRATION TIME; TABLET FORMULATION; TENSILE STRENGTH;

CHEMISTRY, PHARMACEUTICAL; LEUCINE; LUBRICATION; PHARMACEUTIC AIDS; POLYETHYLENE GLYCOLS; TABLETS;

EID: 0041348725     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0939-6411(97)00154-9     Document Type: Article

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