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52
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0141968354
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note
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Nomenclature of the dipeptide building blocks: the first m/p denotes the meta or para position of the protected aldehyde group, the last character indicates the size of the macrocycle (m for monomer) and the middle two characters are the one letter codes for the amino acids, i.e. P for proline, F for phenylalamine, and C for cyclohexylalanine.
-
-
-
-
53
-
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0141899259
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note
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HPLC grade chloroform (Aldrich), stablished by 0.1% (by weight) amylenes was used throughout.
-
-
-
-
54
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0034699478
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note
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Linear oligomers are also present at concentrations which are generally too low to be detected easily, but they can be amplified by binding the terminal protonated hydrazinium ion to 18-crown-6. See: R. L. R. Furlan, G. R. L. Cousins and J. K. M. Sanders, Chem. Commun., 2000, 1761.
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55
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0141899258
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note
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In the presence of NaI libraries generated from pPFm pass through an intermediate stage with relatively large amounts of cyclic dimer, which is only sparingly soluble. The precipitates formed upon starting equilibration from the monomer are slow to redissolve, acting as a kinetic trap, preventing thermodynamic equilibrium from being reached.
-
-
-
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56
-
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0141933638
-
-
note
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The role of the trifluoroacetate anion cannot be assessed, as TFA is always present in large excess.
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58
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