Megestrol acetate-induced weight gain does not negatively affect blood lipids in elderly men: Effects of resistance training and testosterone replacement

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 58, Issue 7, 2003, Pages 644-647

  Lambert, Charles P ^a   Sullivan, Dennis H ^b   Evans, William J ^b  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

HIGH DENSITY LIPOPROTEIN; LIPID; MEGESTROL ACETATE; PLACEBO; TESTOSTERONE ENANTATE; TRIACYLGLYCEROL;

ADIPOSE TISSUE; AGED; ARTICLE; CALORIC INTAKE; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; EXERCISE; HORMONE SUBSTITUTION; HUMAN; MALE; MEDICAL DECISION MAKING; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TIME; TREATMENT INDICATION; WEIGHT GAIN;

EID: 0041343245     PISSN: 10795006     EISSN: None     Source Type: Journal    
DOI: 10.1093/gerona/58.7.m644     Document Type: Article

References (24)

1. Oster MH, Enders SR, Samuels SJ, et al. Megestrol acetate in patients with AIDS and cachexia. Ann Intern Med. 1994;121:400-408.
2. Loprinzi CL, Schaid DJ, Dose AM, Burnham NL, Jensen MD. Body-composition changes in patients who gain weight while receiving megestrol acetate. J Clin Oncol. 1993;11:152-154.
3. Von Roenn JH, Armstrong D, Kotler DP, et al. Megestrol acetate in patients with AIDS-related cachexia. Ann Intern Med. 1994;121:393-399.
4. Tchekmedyian NS, Tait N, Moody M, Aisner J. High-dose megestrol acetate: a possible treatment for cachexia. JAMA. 1987;257:1195-1198.
5. Tchekmedyian NS, Hickman M, Heber D. Treatment of anorexia and weight loss with megestrol acetate in patients with cancer or acquired immunodeficiency syndrome. Sem Oncol. 1991;18:35-42.
6. Tchekmedyian NS, Hickman M, Siau J, et al. Megestrol acetate in cancer anorexia and weight loss. Cancer. 1992;69:1268-1274.
7. Yeh S-S, Wu S-Y, Lee T-P, et al. Improvement in quality-of-life measures and stimulation of weight gain after treatment with megestrol acetate oral suspension in geriatric cachexia: results of a double-blind, placebo-controlled study. J Am Geriatr Soc. 2000;48:485-492.
8. Ciciero LA, Rosenberg JM, Miyashiro A, Maby JI. Megestrol acetate suspension for the treatment of involuntary weight loss in elderly nursing home residents: a retrospective chart review. Consult Pharm. 2000;15:811-814.
9. Lambert CP, Sullivan DH, Freeling SA, Lindquist DM, Evans WJ. Effects of testosterone replacement and/or resistance exercise on the composition of megestrol acetate stimulated weight gain in elderly men: a randomized controlled trial. J Clin Endocrinol Metab. 2002;87:2100-2106.
10. Stadtman TC. Methods in Enzymology. Vol. 3. New York: Academy Press; 1957.
11. Flegg HM. An investigation of the determination of serum cholesterol by an enzymatic method. Ann Clin Biochem. 1973;10:79-84.
12. Roschlau P, Bernt E, Gruber W. Enzymatic determination of total cholesterol in serum [author's translation]. Z Klin Chem Klin Biochem. 1974;12:403-407.
13. Rautela GS, Liedtke RJ. Automated enzymic measurement of total cholesterol in serum. Clin Chem. 1978;24:108-114.
14. Hagen JH, Hagen PB. An enzymatic method for the estimation of glycerol in blood and its use to determine the effect of noradrenaline on the concentration of glycerol in blood. Can J Biochem Physiol. 1962;40:1129.
15. Rautela GS, Hall RG, Bekiesz CL, Wermus GR. A kinetic method for the rapid and automatic measurement of triglycerides in biological fluids. Clin Chem. 1974;20:857.
16. Kinosian B, Glick H, Preiss L, Puder KL. Cholesterol and coronary heart disease: predicting risks in men by changes in levels and ratios. J Investig Med. 1995;43:443-450.
17. Guven M, Dikmen Y, Terek MC, Ozsaran AA, Itil IM, Erhan Y. Metabolic effects associated with high-dose continuous megestrol acetate administration in the treatment of endometrial pathology. Arch Gynecol Obstet. 2001;265:183-186.
18. Farish E, Barnes JF, O'Donoghue F, Fletcher CD, Ekevall K, Hart DM. The role of megestrol acetate as an alternative to conventional hormone replacement therapy. Climacteric. 2000;3:125-134.
19. Kenny AM, Prestwood KM, Gruman CA, Fabregas G, Biskup B, Mansoor G. Effects of transdermal testosterone on lipids and vascular reactivity in older men with low bioavailable testosterone levels. J Gerontol Med Sci. 2002;57A:M460-M465.
20. Singh AB, Hsia S, Alaupovic P, et al. The effects of varying doses of T on insulin sensitivity, plasma lipids, apolipoproteins, and C-reactive protein in healthy young men. J Clin Endocrinol Metab. 2002;87:136-143.
21. Joseph LJ, Davey SL, Evans WJ, Campbell WW. Differential effect of resistance training on the body composition and lipoprotein-lipid profile in older men and women. Metabolism. 1999;48:1474-1480.
22. Fahlman MM, Boardley D, Lambert CP, Flynn MG. Effects of endurance training and resistance training on plasma lipoprotein profiles in elderly women. J Gerontol Biol Sci. 2002;57A:B54-B60.
23. Heath KV, Hogg RS, Singer J, Chan KJ, O'Shaughnessy MV, Montaner JS. Antiretroviral treatment patterns and incident HIV-associated morphologic and lipid abnormalities in a population-based cohort. J AIDS. 2002;30:440-447.
24. Melroe NH, Kopaczewski J, Henry K, Huebsch J. Intervention for hyperlipidemia associated with protease inhibitors. J Assoc Nurses AIDS Care. 1999;10:55-69.