Composite film-coated tablets intended for colon-specific delivery of 5-aminosalicylic acid: Using deesterified pectin

Pharmaceutical Development and Technology

Volumn 8, Issue 3, 2003, Pages 311-318

  Sriamornsak, P ^a   Nunthanid, J ^a   Wanchana, S ^a   Luangtana Anan, M ^a  

^a SILPAKORN UNIVERSITY   (Thailand)

Author keywords

5 aminosalicylic acid; Colon specific delivery; Drug targeting; Eudragit RS; Film coated tablets; Pectin; Polygalacturonic acid

Indexed keywords

EUDRAGIT RS; MESALAZINE; PECTIN; POLYGALACTURONIC ACID; POTASSIUM DERIVATIVE; SODIUM DERIVATIVE;

ARTICLE; CHEMICAL COMPOSITION; COLON; DISPERSION; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG SOLUBILITY; DRUG TARGETING; DRUG TRANSPORT; ESTERIFICATION; FILM COATING; OSMOSIS; PH; PRIORITY JOURNAL; TABLET;

ACRYLIC RESINS; COLON; DRUG DELIVERY SYSTEMS; MESALAMINE; PECTINS; TABLETS, ENTERIC-COATED;

EID: 0041343204     PISSN: 10837450     EISSN: None     Source Type: Journal    
DOI: 10.1081/PDT-120022159     Document Type: Article

References (17)

1. Friend, D.R. Colon-specific drug delivery. Adv. Drug Del. Rev. 1991, 7, 149-199.
2. Bondesen, S.; Rasmussen, S.N.; Rask-Madsen, J.; Nielsen, O.H.; Lauritsen, K.; Binder, V.; Hansen, S.H.; Hvidberg, E.F. 5-Aminosalicylic acid in the treatment of inflammatory bowel disease. Acta Med. Scand 1987, 221, 227-242.
3. Novis, B.H.; Korsets, Z.; Chen, P. Nephrotic syndrome after treatment with 5-amino salicylic acid. Br. Med. J. 1988, 296, 1442.
4. Ashford, M.; Fell, J.T.; Attwood, D.; Woodhead, P.J. An in-vitro investigation into the suitability of pH dependent polymers for colonic targeting. Int. J. Pharm. 1992, 91, 241-245.
5. Rubinstein, A.; Radai, R. In-vitro and in-vivo analysis of colon specificity of calcium pectinate formulations. Eur. J. Pharm. Biopharm. 1995, 41, 291-295.
6. Leopold, C.S. Coated dosage forms for colon-specific drug delivery. Pharm. Sci. Technol. Today 1999, 2, 197-204.
7. Siew, L.F.; Basit, A.W.; Newton, J.M. The potential of organic-based amylose-ethylcellulose film coating as oral colon-specific drug delivery systems. AAPS Pharm. Sci. Tech. 2000, 1, article 22.
8. Warkerly, Z.; Fell, J.T.; Attwood, D.; Parkins, D. Studies on drug release from pectin/ethylcellulose film-coated tablets: a potential colonic delivery system. Int. J. Pharm. 1997, 153, 219-224.
9. Semde, R.; Amighi, K.; Devleeschouwer, M.J.; Moes, A.J. Effect of pectinolytic enzymes on the theophylline release from pellets coated with water insoluble polymers containing pectin HM or calcium pectinate. Int. J. Pharm. 2000, 197, 169-179.
10. Semde, R.; Amighi, K.; Devleeschouwer, M.J.; Moes, A.J. Studies of pectin HM/Eudragit RL/Eudragit NE film-coating formulations intended for colonic drug delivery. Int. J. Pharm. 2000, 197, 181-192.
11. Sriamornsak, P. Investigation of pectin as a carrier for oral delivery of proteins using calcium pectinate gel beads. Int. J. Pharm. 1998, 169, 213-220.
12. Sriamornsak, P. Effect of calcium concentration, hardening agent and drying condition on release characteristics of oral proteins from calcium pectinate gel beads. Eur. J. Pharm. Sci. 1999, 8, 221-227.
13. Semde, R.; Amighi, K.; Pierre, D.; Devleeschouwer, M.J.; Moes, A.J. Leaching of pectin from mixed pectin insoluble polymer films intended for colonic drug delivery. Int. J. Pharm. 1998, 174, 233-241.
14. Jensen, J.; Cornett, C.; Olsen, C.E.; Tjornelund, J.; Hansen, S.H. Identification of major degradation products of 5-aminosalicylic acid formed in aqueous solutions and in pharmaceuticals. Int. J. Pharm. 1992, 88, 177-187.
15. Warkerly, Z.; Fell, J.T.; Attwood, D.; Parkins, D. In vitro evaluation of pectin-based colonic drug delivery systems. Int. J. Pharm. 1996, 129, 73-77.
16. Davis, S.S.; Hardy, J.G.; Fara, J.W. Transit of pharmaceutical dosage forms through the small intestine. Gut 1986, 27, 886-892.
17. Rekhi, G.S.; Porter, S.C.; Jambhekar, S.S. Mechanism and some factors affecting the release of propanolol hydrochloride from beads coated with aqueous polymeric dispersions. Proc. Int. Symp. Control Rel. Bioact. Mater. 1989, 15, 372-373.