Identification of S-sulfonation and S-thiolation of a novel transthyretin Phe33Cys variant from a patient diagnosed with familial transthyretin amyloidosis

Protein Science

Volumn 12, Issue 8, 2003, Pages 1775-1785

  Lim, Amareth ^a   Prokaeva, Tatiana ^a   McComb, Mark E ^a   Connors, Lawreen H ^a   Skinner, Martha ^a   Costello, Catherine E ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Amyloidosis; Enzymatic digest; Mass spectrometry; Peptide mapping; Posttranslational modification; S sulfonation; S thiolation; Transthyretin

Indexed keywords

AMYLOID; CYSTEINE; PHENYLALANINE; PREALBUMIN; SULFONIC ACID DERIVATIVE; THIOL DERIVATIVE;

ADULT; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; AUTOSOMAL DISORDER; BLOOD; BONE MARROW BIOPSY; CASE REPORT; CHEMISTRY; CLINICAL FEATURE; CONJUGATION; DISEASE ASSOCIATION; DISEASE COURSE; DNA SEQUENCE; ELECTROSPRAY MASS SPECTROMETRY; FAMILIAL AMYLOIDOSIS; FAMILIAL TRANSTHYRETIN AMYLOIDOSIS; FEMALE; GENETICS; HUMAN; HUMAN TISSUE; IMMUNOPRECIPITATION; LIVER TRANSPLANTATION; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; METABOLISM; MISSENSE MUTATION; MOLECULAR GENETICS; OXIDATIVE STRESS; PATHOGENESIS; PEPTIDE MAPPING; PLASMA; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN ISOLATION; PROTEIN PROCESSING; PROTEIN VARIANT; SEQUENCE ANALYSIS; SYMPTOM; TREATMENT OUTCOME; WILD TYPE;

AMINO ACID SEQUENCE; AMYLOIDOSIS, FAMILIAL; CYSTEINE; FEMALE; HUMANS; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; OXIDATIVE STRESS; PEPTIDE MAPPING; PHENYLALANINE; PREALBUMIN; PROTEIN CONFORMATION; SEQUENCE ANALYSIS, DNA; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 0041341882     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.0349703     Document Type: Article

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