Novel synthesis of nucleoside 5'-polyphosphates

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 21, 1996, Pages 2571-2574

  Hoffmann, C ^a   Genieser, H G ^b   Veron, M ^c   Jastorff, B ^a  

^a UNIVERSITY OF BREMEN   (Germany)

^b BIOLOG Life Science Institute   (Germany)

^c INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEOSIDE DERIVATIVE; NUCLEOSIDE DIPHOSPHATE; NUCLEOSIDE DIPHOSPHATE KINASE; NUCLEOSIDE TRIPHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; DICTYOSTELIUM DISCOIDEUM; DRUG SYNTHESIS; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; REACTION ANALYSIS; TECHNIQUE; ULTRAVIOLET SPECTROPHOTOMETRY;

DICTYOSTELIUM DISCOIDEUM;

EID: 0040934911     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(96)00461-1     Document Type: Article

References (15)

1. 1. Ludwig, J. Acta Biochim. Biophys. Acad. Sci. Hung., 1981, 16, 131-133.
2. 2. Kovacs, T.; Otvos, L. Tetrahedron Lett., 1988, 29, 4225-4228.
3. 3. Moffat, J. G. Can. J. Chem., 1964, 42, 599-604.
4. 4. Hoard, D. E.; Ott, D. G. J. Am. Chem. Soc., 1965, 87, 1785-1788.
5. 5. Simon, E.S.; Grabowski S.; Whitesides G.M. J. Org. Chem., 1990, 55, 1834-1841.
6. 6. Schobert, B. Anal. Biochem., 1995, 226, 288-292.
7. 7. Davisson, V. J.; Davis, D. R.; Dixit, V. M.; Poulter, C. D. J. Org. Chem., 1987, 52, 1794-1801.
8. 8. Mishra, N. C.; Broom, A.D. J. Chem. Soc., Chem. Commun., 1991, 1276-1277.
9. 9. Yoshikawa, M.; Kato, T.; Takenishi, T. Bull. Chem. Soc. Jpn., 1969, 42, 3505-3508.
10. 10. 5,6-DClBIR = 5,6-dichlorobenzimidazole-β-D-ribofuranoside.
11. 11. Scheit, K. H. Nucleotide analogs, synthesis and biological functions; John Wiley & Sons, New York 1980 and references cited therein.
12. 12. Bourdais, J.; Biondi R.; Safrati, S.; Guerreiro, C.; Lascu, I.; Veron, M. J. Biol. Chem. 1996, 277, 7887-7890.
13. 13. adenosine-5′-triphosphate (ATP); 6-chloropurine-β-D-ribofuranosyl-5'-triphosphate (6-Cl-PuTP); tubercidine-β-D-ribofuranosyl-5'-triphosphate (TuTP); 8-chloro-adenosine-5'-triphosphate (8-Cl-ATP); 5,6-dichloro-benzimidazole-β-D-ribofuranosyl-5'-triphosphate (5,6-DCl-BITP), and nebularine-5'-triphosphate (NeTP) = purine-β-D-ribofuranosyl-5'-triphosphate, respectively.
14. maxs = 262 nm.
15. max = 253, 286, 294 nm.