PTH and PTHrP: Similar structures but different functions

News in Physiological Sciences

Volumn 14, Issue 6, 1999, Pages 243-248

  Schluter K D ^a  

^a Physiologisches Institut   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0040714211     PISSN: 08861714     EISSN: None     Source Type: Journal    
DOI: 10.1152/physiologyonline.1999.14.6.243     Document Type: Article

References (13)

1. Clark, J. A., T. I. Bonner, A. S. Kim, and T. B. Usdin. Multiple regions of ligand discrimination revealed by analysis of chimeric parathyroid hormone 2 (PTH2) and PTH/PTH-related peptide (PTHrP) receptors. Mol. Endocrinol. 12: 193-206, 1998.
2. Fenton, A. J., B. E. Kemp, R. G. Hammonds, Jr., K. Mitchelhill, J. M. Moseley, T. J. Martin, and G. C. Nicholson. A potent inhibitor of osteoclastic bone resorption within a highly conserved pentapeptide region of parathyroid hormone-related protein; PTHrP[107-111]. Endocrinology 129: 3424-3426, 1991.
3. Gagnon, L., H. Jouishomme, J. F. Whitfield, J. P. Durkin, S. MacLean, W. Neugebauer, G. Willick, R. H. Rixon, and B. Chakravarthy. Protein kinase C-activating domains of parathyroid hormone-related protein. J. Bone Miner. Res. 8: 497-503, 1993.
4. Hara, M., Y. M. Liu, L. Zhen, I. S. Cohen, H. Yu, P. Danilo, Jr., K. Ogino, J. P. Bileikian, and M. R. Rosen. Positive chronotropic actions of parathyroid hormone and parathyroid hormone-related peptide are associated with increases in the current, l(f), and the slope of the pacemaker potential. Circulation 96: 3704-3709, 1997.
5. Juppner, H., A. B. Abou-Samra, M. Freeman, X. F. Kong, E. Schipani, J. Richards, L. F. Kolakowski, Jr., J. Hock, J. T. Potts, Jr, H. M. Kronenberg, and G. V. Segre. A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide. Science 254: 1024-1026, 1991.
6. May, L. G., and C. V. Gay. Parathyroid hormone uses both adenylate cyclase and protein kinase C to regulate acid production in osteoclasts. J. Cell. Biochem. 65: 565-573, 1997.
7. McGowan, J. A., T. C. Chen, J. Fragola, J. B. Puschett, and M. Rosenblatt. Parathyroid hormone: effects of the 3-34 fragment in vivo and vitro. Science 219: 67-69, 1983.
8. Potts, J. T., Jr., H. M. Kronenberg, and M. Rosenblatt. Parathyroid hormone: chemistry, biosynthesis, and mode of action. Adv. Protein Chem. 35: 323-396, 1982.
9. Rihani-Bisharat, S., G. Maor, and D. Lewinson. In vivo anabolic effects of parathyroid hormone (PTH) 28-48 and N-terminal fragments of PTH and PTH-related protein on neonatal mouse bones. Endocrinology 139: 974-981, 1998.
10. Sato, S., M. Ohta, Y. Kawaguchi, H. Okada, M. Ono, H. Saito, M. Utsunomiya, T. Tamura, K. Sugimoto, S. Takamizawa, H. Tanaka, T. Shigematsu, K. Tojo, and O. Sakai. Effects of parathyroidectomy on left ventricular mass in patients with hyperparathyroiclism. Miner. Electrolyte Metab. 21: 67-71, 1995.
11. Schlüter, K.-D., H. Hellstern, E. Wingender, and H. Mayer. The central part of parathyroid hormone stimulates thymidine incorporation of chondrocytes. J. Biol. Chem. 264: 11087-11092, 1989.
12. Schlüter, K.-D., and H. M. Piper. Cardiovascular actions of parathyroid hormone and parathyroid hormone-related pepticle. Cardiovasc. Res. 37: 34-41, 1998.
13. Schlüter, K.-D., E. Wingender, W. Tegge, and H. M. Piper. Parathyroid hormone-related peptide antagonizes the action of parathyroid hormone on adult cardiomyocytes. J. Biol. Chem. 271: 3074-3078, 1996.