Mutations in the sixth transmembrane domain of P-glycoprotein that alter the pattern of cross-resistance also alter sensitivity to cyclosporin A reversal

Molecular Pharmacology

Volumn 51, Issue 6, 1997, Pages 922-930

  Ma, Jian Feng ^a   Grant, Geraldine ^a   Melera, Peter W ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN A; GLYCOPROTEIN P; MEMBRANE PROTEIN; VERAPAMIL; VINCRISTINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CANCER; CANCER CHEMOTHERAPY; CROSS RESISTANCE; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

EID: 0040700700     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.51.6.922     Document Type: Article

References (29)

1. Higgins, C. F. ATP transporters: from microorganisms to man. Annu. Rev. Cell Biol. 8:67-113 (1992).
2. Riordan, J. R., J. M. Rommens, B.-S. Kerem, N. Alon, R. Rozmahel, Z. Grze Iczack, J. Zieleinsky, S. Lok, J. L. Chou, M. L. Drumm, F. S. Collins, and L. C. Tsui. Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. Science (Washington D. C.) 245:1066-1073 (1989).
3. Anderson, M. P., R. J. Gregory, S. Thompson, D. W. Souza, S. Paul, R. C. Mulligan, A. E. Smith, and M. J. Welch. Demonstration that CFTR is a chloride channel by alteration of its anion selectivity. Science (Washington D. C.) 253:202-205 (1991).
4. Felmlee, J., S. Pellett, and R. A. Welch. Nucleotide sequence of an Escherichia coli chromosomal haemolysin. J. Bacteriol. 163:94-105 (1985).
5. Hess, J., W. Wels, M. Vogel, and W. Goebel. Nucleotide sequence of a plasmid-encoded haemolysin determinant and its comparison with a corresponding chromosomal haemolysin sequence. FEMS Microbiol. Lett. 34: 1-11 (1986).
6. Gottesman, M. M., and I. Pastan. Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu. Rev. Biochem. 62:385-427 (1993).
7. 1 transcripts in multidrug resistant Chinese hamster lung cells. J. Biol. Chem. 266:4545-4555 (1991).
8. Devine, S. E., V. Ling, and P. W. Melera. Amino acid substitutions in the sixth transmembrane of P-glycoprotein alter multidrug resistance. Proc. Natl. Acad. Sci. USA 89:4564-4568 (1992).
9. Choi, K., C.-J. Chen, M. Kriegler, and I. B. Roninson. An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene. Cell 53:519-529 (1988).
10. Gros, P., R. Dhir, J. Croop, and F. Talbot. A single amino acid substitution strongly modulates the activity and substrate specificity of the mouse mdrl and mdr2 drug efflux pumps. Proc. Natl. Acad. Sci. USA 88:7289-7293 (1981).
11. Currier, S. J., S. E. Kane, M. C. Willingham, C. O. Cardarelli, I. Pastan, and M. M. Gottesman. Identification of residues in the first cytoplasmic loop of P-glycoprotein involved in the function of chimeric human MDR1-MDR2 transporters. J. Biol. Chem. 267:25153-25159 (1992).
12. Loo, T. W., and D. M. Clark. Functional consequences of glycine mutations in the predicted cytoplasmic loops of P-glycoprotein. J. Biol. Chem. 269: 7243-7248 (1994).
13. 939/941. Biochemistry 33:5041-5048 (1994).
14. Yusa, K., and T. Tsuruo. Reversal mechanism of multidrug resistance by verapamil: direct binding of verapamil to P-glycoprotein on specific sites and transport of verapamil outward across the plasma membrane of K562/ADM cells. Cancer Res. 49:5002-2006 (1989).
15. Tamai, I., and A. R. Safa. Competitive interaction of cyclosporins with the vinca alkaloid-binding site of P-glycoprotein in multidrug-resistant cells. J. Biol. Chem. 265:16509-16513 (1990).
16. Twentyman, P. R. Cyclosporins as drug resistance modifiers. Biochem. Pharmacol. 43:109-117 (1992).
17. Safa, A. R. Photoaffinity labeling of P-glycoprotein in multidrug-resistant cells. Cancer Invest. 11:46-56 (1993).
18. Morris, D. I., L. M. Greenberger, E. P. Bruggemann, C. Cardarelli, M. M. Gottesman, I. Pastan, and K. B. Seaman. Localization of the forskolin labeling sites to both halves of P-glycoprotein: similarity of the sites labeled by forskolin and prazosin. Mol. Pharmacol. 46:329-337 (1994).
19. Bruggemann, E. P., S. J. Currier, M. M. Gottesman, and I. Pastan. Characterization of the azidopine and vinblastine binding site of P-glycoprotein. J. Biol. Chem. 267:21020-21026 (1992).
20. Greenberger, L. M. Major photo affinity drug labeling sites for iodoaryl azidoprazosin in P-glycoprotein are within or immediately C-terminal to transmembrane domains 6 and 12. J. Biol. Chem. 268:11417-11425 (1993).
21. Tabcharani, J. A., S. M. Rommens, Y.-X. Hou, X.-B. Chang, L.-C. Tsul, J. R. Riordan, and J. W. Hanrahan. Multi-ion pore behavior in the CFTR chloride channel. Nature (Land.) 336:79-82 (1993).
22. Devine, S. E., and P. W. Melera. Diversity of multidrug resistance in mammalian cells. J. Biol. Chem. 269:6133-6139 (1994).
23. Loo, T. W., and D. M. Clarke. Mutations to amino acids located in predicted transmembrane segment 6 (TM6) modulate the activity and substrate specificity of human P-glycoprotein. Biochemistry 33:14049-14057 (1994).
24. Gunning, P., J. Leavitt, G. Muscat, S.-Y. Nq, and L., Kedes. A human β-actin expression vector directs high-level accumulation of antisense transcripts. Proc. Natl. Acad. Sci. USA 84:4831-4835 (1987).
25. 1 gene. Cancer Chemother. Pharmacol. 33:465-471 (1994).
26. Branden, C., and J. Tooze. Introduction to Protein Structure. Garland Publishing, New York, 1-10 (1991).
27. Kyte, J., and R. F. Doolittle. A simple method for displaying the hydropathic character of a protein. J. Mol. Biol. 157:105-132 (1982).
28. Biedler, J. L., and B. A. Spengler. Collateral sensitivity in multidrug resistance, in Reversal of Multidrug Resistance in Cancers (J. A. Kellen, ed.). CRC Press, Boca Raton, 21-46 (1994).
29. Cardarelli, C. O., I. Aksentijevich, I. Pastan, and M. Gottesman. Differential effects of P-glycoprotein inhibitors on NIH3T3 cells transfected with wild-type (G185) or mutant (V185) multidrug transporters. Cancer Res. 55:1086-1091 (1995).