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Volumn 37, Issue 17, 1998, Pages 2381-2384

Crystal structures of actinomycin D and actinomycin Z3

Author keywords

Actinomycins; Antibiotics; Dimerizations; Structure elucidation

Indexed keywords


EID: 0040594857     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-3773(19980918)37:17<2381::AID-ANIE2381>3.0.CO;2-L     Document Type: Article
Times cited : (28)

References (33)
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  • 4
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    • Ed.: P. G. Sammes, Ellis Horwood, Chichester
    • c) A. B. Mauger in Topics in Antibiotic Chemistry, Vol. 5 (Ed.: P. G. Sammes), Ellis Horwood, Chichester, 1980, pp. 224-306.
    • (1980) Topics in Antibiotic Chemistry , vol.5 , pp. 224-306
    • Mauger, A.B.1
  • 10
    • 0026637211 scopus 로고
    • a) S. Kamitori, F. Takusagawa, J. Mol. Biol. 1992, 225, 445-456; M. Shinomiya, W. Chu, R. G. Carlson, R. F. Weaver, F. Takusagawa, Biochemistry 1995, 34, 8481-8491.
    • (1992) J. Mol. Biol. , vol.225 , pp. 445-456
    • Kamitori, S.1    Takusagawa, F.2
  • 13
    • 0344278494 scopus 로고    scopus 로고
    • note
    • Three different conformations of DNA/actinomycin D complexes are described in reference [6]; the depsipeptide rings adapt themselves to the appropriate "size" of the minor groove of the DNA.
  • 14
    • 0014716785 scopus 로고
    • a) H. Lackner, Chem. Ber. 1970, 103, 2476-2500;
    • (1970) Chem. Ber. , vol.103 , pp. 2476-2500
    • Lackner, H.1
  • 17
    • 0344278492 scopus 로고
    • b) M. F. Perutz, Nature 1964, 201, 814.
    • (1964) Nature , vol.201 , pp. 814
    • Perutz, M.F.1
  • 18
    • 0344710459 scopus 로고    scopus 로고
    • note
    • 3 both D-valine subunits of actinomycin D are replaced by D-allo-isoleucine.
  • 22
    • 0344710458 scopus 로고    scopus 로고
    • note
    • [23] All non-hydrogen atoms could be refined anisotropically. The hydrogen atoms were placed in geometrically ideal positions and refined with a riding model, in which the methyl groups (except those of solvent molecules) could rotate about their local threefold axes. All disorders could be resolved and refined anisotropically with the help of distance and ADP restraints. The crystallographic data of the structures described in this publication have been deposited with the Protein Data Bank (PDB), Brookhaven National Laboratory, under the codes 1A7Y und 1A7Z.
  • 23
    • 0345140906 scopus 로고    scopus 로고
    • note
    • [17]
  • 25
    • 0016713585 scopus 로고
    • H. Lackner, Angew. Chem. 1975, 87, 400-411; Angew. Chem. Int. Ed. Engl. 1975, 14, 375-386.
    • (1975) Angew. Chem. , vol.87 , pp. 400-411
    • Lackner, H.1
  • 26
    • 0016418839 scopus 로고
    • H. Lackner, Angew. Chem. 1975, 87, 400-411; Angew. Chem. Int. Ed. Engl. 1975, 14, 375-386.
    • (1975) Angew. Chem. Int. Ed. Engl. , vol.14 , pp. 375-386
  • 27
    • 0345140905 scopus 로고    scopus 로고
    • note
    • [24]
  • 28
    • 0345572455 scopus 로고    scopus 로고
    • note
    • The distances between the threonine nitrogen atoms and N10 (2.88 Å in A, 2.94 Å in B) are in the range for hydrogen bonds, but this is not true of the N(Thr)-H(Thr) ⋯ N10 angles.
  • 29
    • 0344710457 scopus 로고    scopus 로고
    • note
    • The corresponding torsion angles H-N(Thr)-C(Thr)-H lie in the range of 146.6 ° to 155.2 ° in all five molecules.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.