Analysis of tetrahedral carbon in QSAR studies. A case study using 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors

Journal of Chemical Information and Computer Sciences

Volumn 39, Issue 4, 1999, Pages 650-653

  Prabhakar, Yenamandra S ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0040292069     PISSN: 00952338     EISSN: None     Source Type: Journal    
DOI: 10.1021/ci980047s     Document Type: Article

References (5)

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2. Hansch, C.; Leo, A. Substituent Constants for Correlation Analysis in Chemistry and Biology. John Wiley: New York, 1979.
3. Moriguchi, I.; Kanada, Y.; Komatsu, K. Van der Waals volume and related parameters for hydrophobicity in structure-activity studies. Chem. Pharm. Bull. 1976, 24, 1799-1806.
4. Prabhakar, Y. S.; Saxena, A. K.; Doss, M. J. QSAR study of the role of hydrophobicity in the activity of HMGR inhibitors. Drug Des. Delivery 1989, 4, 97-108.
5. Prabhakar, Y. S. QSAR study of HMGR inhibitors: 7-(heteroaryl)-3,5-dihydroxy-6-heptenoic (-heptanoic) acids. Drug Des. Discovery 1992, 9, 145-154.