Synthesis of 1-(2-naphthoyl) benzotriazoles as photoactivated DNA cleaving agents

Archives of Pharmacal Research

Volumn 20, Issue 2, 1997, Pages 197-199

  Yang, Jae Wook ^a   Wender, Paul A ^b  

^a Sahmyook University   (South Korea)

^b STANFORD UNIVERSITY   (United States)

Author keywords

Benzotriazole; Benzotriazole 5 carboxylic acid; Photoactivated DNA cleaving agents

Indexed keywords

EID: 0040278289     PISSN: 02536269     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02974011     Document Type: Article

References (11)

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3. Goldberg, I. H., Chin, D-H, Identification of the active species responsible for Holo-Neocarzinostatin-lnduced DNA Cleavage, J. Am. Chem. Soc., 115, 9341-9342 (1993).
4. Kadaba, P. K., Esterification of heterocyclic Carboxylic acids using boron trifluoride etherate-alcohol reagent., SYNTHESIS, No.11, 628-630 (1972).
5. McCullagh, L., Burgess, E. M., Carithers, R., Photochemical decomposition of 1H-1,2,3-triazole derivatives, J. Am. Chem. Soc., 90, 1923-1924 (1968).
6. Saito, I., Takayama, M., Skurai, T., Photogeneration of Carbocation via Intramolecular Electron Transfer: Photoinduced DNA Alkylation, J. Am. Chem. Soc., 116, 2653-2654 (1994).
7. Watson, J. D., Tooze, J., Kurtz, D. T. Recombinant DNA: a Short Course. W.H. Freeman and Co., NY, 1983.
8. Wender, P. A., Kelly, R. C., Beckham, S., Miller, B. L., Studies on DNA-cleaving agents: computer modeling analysis of the mechanism of activation and cleavage of dynemicin-oligonucleotide complexes, Proc. Natl. Acad Sci. USA, 88, 8835-8839 (1991).
9. 3): 8.88 (s, 1H), 8. 46 (d, J=8.4, 1H), 8.24 (dd, J=8.4, 1.8, 1H), 8.21 (d, J=8.4, 1H), 8.05 (d, 6 Hz, 1H), 8.03 (d, J=8.1, 1H), 7.96 (d, J=8.4, 1 H), 7.78-7.56 (m, 4H)
10. 6): 8.57 (s, 1H), 8.04 (d, J=8.7, 1H), 7.99 (d, J=8.7, 1H), 4.34 (t, J=6. 3, 2H), 3.48 (t, J=6.3, 2H), 1.80 (m, 2H), 1.59 (m, 2H)
11. 2-), 1.95-1.91 (m, 4H, 2″, 3″)