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Volumn 8, Issue 1, 1999, Pages 85-96

Cloning and expression of a novel juvenile hormone-metabolizing epoxide hydrolase during larval-pupal metamorphosis of the cabbage looper, Trichoplusia ni

Author keywords

Cabbage looper; Epoxide hydrolase; Juvenile hormone; Trichoplusia ni

Indexed keywords

AMINO ACID SEQUENCE; BACULOVIRUS; BASE PAIRING; CDNA LIBRARY; CLONING; COMPLEMENTARY DNA; ENZYME ACTIVITY; EPOXIDE HYDROLASE; JUVENILE HORMONE; LEPIDOPTERA; OPEN READING FRAME; SDS POLYACRYLAMIDE GEL ELECTROPHORESIS; SOUTHERN BLOTTING; VIRUS EXPRESSION; VIRUS INFECTION;

EID: 0039915284     PISSN: 09621075     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2583.1999.810085.x     Document Type: Article
Times cited : (36)

References (55)
  • 1
    • 0029664614 scopus 로고    scopus 로고
    • 523 form the catalytic triad of rat soluble epoxide hydrolase
    • 523 form the catalytic triad of rat soluble epoxide hydrolase. J Biol Chem 271: 4223-4229.
    • (1996) J Biol Chem , vol.271 , pp. 4223-4229
    • Arand, M.1    Wagner, H.2    Oesch, F.3
  • 3
    • 0027219730 scopus 로고
    • cDNA cloning and expression of a soluble epoxide hydrolase from human liver
    • Beetham, J.K., Tian, T. and Hammock, B.D. (1993) cDNA cloning and expression of a soluble epoxide hydrolase from human liver. Arch Biochem Biophys 305: 197-201.
    • (1993) Arch Biochem Biophys , vol.305 , pp. 197-201
    • Beetham, J.K.1    Tian, T.2    Hammock, B.D.3
  • 4
    • 0024449558 scopus 로고
    • Degradation of apolipoprotein II mRNA occurs via endonucleolytic cleavage at 5′-AAU-3′/5′-UAA-3′ elements in single-stranded loop domains of the 3′-noncoding region
    • Binder, R., Hwang, S-P.L., Ratnasabapathy, R. and Williams, D.L. (1989) Degradation of apolipoprotein II mRNA occurs via endonucleolytic cleavage at 5′-AAU-3′/5′-UAA-3′ elements in single-stranded loop domains of the 3′-noncoding region. J Biol Chem 264: 16910-16918.
    • (1989) J Biol Chem , vol.264 , pp. 16910-16918
    • Binder, R.1    Hwang, S.-P.L.2    Ratnasabapathy, R.3    Williams, D.L.4
  • 5
    • 0026574135 scopus 로고
    • Occurrence of fatty acid epoxide hydrolases in soybean (Glycine max): Purification and characterization of the soluble form
    • Blee, E. and Schuber, F. (1992) Occurrence of fatty acid epoxide hydrolases in soybean (Glycine max): purification and characterization of the soluble form. Biochem J 282: 711-714.
    • (1992) Biochem J , vol.282 , pp. 711-714
    • Blee, E.1    Schuber, F.2
  • 6
    • 0028856676 scopus 로고
    • Mechanism of soluble epoxide hydrolase: Formation of an α-hydroxy ester-enzyme intermediate through Asp-333
    • Borhan, B., Jones, A.D., Pinot, F., Grant, D.F., Kurth, M.J. and Hammock, B.D. (1995) Mechanism of soluble epoxide hydrolase: formation of an α-hydroxy ester-enzyme intermediate through Asp-333. J Biol Chem 270: 26923-26930.
    • (1995) J Biol Chem , vol.270 , pp. 26923-26930
    • Borhan, B.1    Jones, A.D.2    Pinot, F.3    Grant, D.F.4    Kurth, M.J.5    Hammock, B.D.6
  • 7
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford, M.M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analyt Biochem 72: 248-254.
    • (1976) Analyt Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 8
    • 4344639234 scopus 로고
    • Epoxide hydrolase activity on juvenile hormone in Manduca sexta
    • Casas, J., Harshman, L.G. and Hammock, B.D. (1991) Epoxide hydrolase activity on juvenile hormone in Manduca sexta. Insect Biochem 21: 17-26.
    • (1991) Insect Biochem , vol.21 , pp. 17-26
    • Casas, J.1    Harshman, L.G.2    Hammock, B.D.3
  • 9
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski, P. and Sacchi, N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Analyt Biochem 162: 156-159.
    • (1987) Analyt Biochem , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 10
    • 0344541569 scopus 로고
    • Partial nucleotide sequence of a cloned cDNA for human liver microsomal epoxide hydrolase
    • Craft, J.A., Jackson, M.R. and Burchell, B. (1986) Partial nucleotide sequence of a cloned cDNA for human liver microsomal epoxide hydrolase. Biochem Soc Trans 15: 708-709.
    • (1986) Biochem Soc Trans , vol.15 , pp. 708-709
    • Craft, J.A.1    Jackson, M.R.2    Burchell, B.3
  • 11
    • 0002652592 scopus 로고    scopus 로고
    • Regulation of JH titers: The relevance of degradative enzymes and binding proteins
    • de Kort, C.A.D. and Granger, N.A. (1996) Regulation of JH titers: the relevance of degradative enzymes and binding proteins. Arch Insect Biochem Physiol 33: 1-26.
    • (1996) Arch Insect Biochem Physiol , vol.33 , pp. 1-26
    • De Kort, C.A.D.1    Granger, N.A.2
  • 12
    • 0023664359 scopus 로고
    • Structure and organization of the microsomal xenobiotic epoxide hydrolase gene
    • Falany, C.N., McQuiddy, P. and Kasper, C.B. (1987) Structure and organization of the microsomal xenobiotic epoxide hydrolase gene. J Biol Chem 262: 5924-5930.
    • (1987) J Biol Chem , vol.262 , pp. 5924-5930
    • Falany, C.N.1    McQuiddy, P.2    Kasper, C.B.3
  • 13
    • 0000145803 scopus 로고
    • Isolation and characterization of an insecticide-resistance-associated esterase in the tobacco budworm Heliothis virescens (F.)
    • Goh, D.K.S., Anspaugh, D.D., Motoyama, N., Rock, G.G. and Roe, R.M. (1995) Isolation and characterization of an insecticide-resistance-associated esterase in the tobacco budworm Heliothis virescens (F.). Pestic Biochem Physiol 51: 192-204.
    • (1995) Pestic Biochem Physiol , vol.51 , pp. 192-204
    • Goh, D.K.S.1    Anspaugh, D.D.2    Motoyama, N.3    Rock, G.G.4    Roe, R.M.5
  • 14
    • 0027171486 scopus 로고
    • Molecular cloning and expression of murine liver soluble epoxide hydrolase
    • Grant, D.F., Storms, D.H. and Hammock, B.D. (1993) Molecular cloning and expression of murine liver soluble epoxide hydrolase. J Biol Chem 268: 17628-17633.
    • (1993) J Biol Chem , vol.268 , pp. 17628-17633
    • Grant, D.F.1    Storms, D.H.2    Hammock, B.D.3
  • 15
    • 0027145512 scopus 로고
    • Juvenile hormone catabolism in Manduca sexta: Homologue selectivity of catabolism and identification of a diolphosphate conjugate as a major end product
    • Halarnkar, P.P., Jackson, G.P., Straub, K.M. and Schooley, D.A. (1993) Juvenile hormone catabolism in Manduca sexta: homologue selectivity of catabolism and identification of a diolphosphate conjugate as a major end product. Experientia 49: 988-994.
    • (1993) Experientia , vol.49 , pp. 988-994
    • Halarnkar, P.P.1    Jackson, G.P.2    Straub, K.M.3    Schooley, D.A.4
  • 16
    • 0021213712 scopus 로고
    • Substituted thiotrifluoropropanones as potent selective inhibitors of juvenile hormone esterase
    • Hammock, B.D., Abdel-Aal, Y.A.I., Mullin, C.A., Hanzlik, T.N. and Roe, R.M. (1984) Substituted thiotrifluoropropanones as potent selective inhibitors of juvenile hormone esterase. Pestic Biochem Physiol 22: 209-223.
    • (1984) Pestic Biochem Physiol , vol.22 , pp. 209-223
    • Hammock, B.D.1    Abdel-Aal, Y.A.I.2    Mullin, C.A.3    Hanzlik, T.N.4    Roe, R.M.5
  • 18
    • 0024311510 scopus 로고
    • Rabbit microsomal epoxide hydrolase: Isolation and characterization of the xenobiotic metabolizing enzyme cDNA
    • Hassett, C., Turnblom, S.M., DeAngeles, A. and Omiecinski, C.J. (1989) Rabbit microsomal epoxide hydrolase: isolation and characterization of the xenobiotic metabolizing enzyme cDNA. Arch Biochem Biophys 271: 380-389.
    • (1989) Arch Biochem Biophys , vol.271 , pp. 380-389
    • Hassett, C.1    Turnblom, S.M.2    DeAngeles, A.3    Omiecinski, C.J.4
  • 19
    • 0027303971 scopus 로고
    • A PCR-based method for high stringency screening of cDNA libraries
    • Israel, D.I. (1993) A PCR-based method for high stringency screening of cDNA libraries. Nucleic Acids Res 21: 2627-2631.
    • (1993) Nucleic Acids Res , vol.21 , pp. 2627-2631
    • Israel, D.I.1
  • 20
    • 84990437071 scopus 로고
    • Juvenile hormone metabolism in the plasma, integument, midgut, fat body, and brain during the last instar of the tobacco hornworm, Manduca sexta (L.)
    • Jesudason, P., Anspaugh, D.D. and Roe, R.M. (1992) Juvenile hormone metabolism in the plasma, integument, midgut, fat body, and brain during the last instar of the tobacco hornworm, Manduca sexta (L.). Arch Insect Biochem Physiol 20: 87-105.
    • (1992) Arch Insect Biochem Physiol , vol.20 , pp. 87-105
    • Jesudason, P.1    Anspaugh, D.D.2    Roe, R.M.3
  • 21
    • 0010173502 scopus 로고    scopus 로고
    • In vivo and in wYro-tissue specific metabolism of juvenile hormone during the last stadium of the cabbage looper, Trichoplusia ni
    • Kallapur, V.L., Majumder, C. and Roe, R.M. (1996) In vivo and in wYro-tissue specific metabolism of juvenile hormone during the last stadium of the cabbage looper, Trichoplusia ni. J Insect Physiol 42: 181-190.
    • (1996) J Insect Physiol , vol.42 , pp. 181-190
    • Kallapur, V.L.1    Majumder, C.2    Roe, R.M.3
  • 22
    • 0028485440 scopus 로고
    • Characterization of an Arabidopsis cDNA for a soluble epoxide hydrolase gene that is inducible by auxin and water stress
    • Kiyosue, T., Beetham, J.K., Pinot, F., Hammock, B.D., Yamaguchi-Shinozaki, K. and Shinozaki, K. (1994) Characterization of an Arabidopsis cDNA for a soluble epoxide hydrolase gene that is inducible by auxin and water stress. Plant J 6: 259-269.
    • (1994) Plant J , vol.6 , pp. 259-269
    • Kiyosue, T.1    Beetham, J.K.2    Pinot, F.3    Hammock, B.D.4    Yamaguchi-Shinozaki, K.5    Shinozaki, K.6
  • 23
    • 0027182044 scopus 로고
    • Isolation and characterization of a cDNA encoding rat liver cytosolic epoxide hydrolase and its functional expression in Escherichia coli
    • Knehr, M., Thomas, H., Arand, M., Gebel, T., Zeller, H. and Oesch, F. (1993) Isolation and characterization of a cDNA encoding rat liver cytosolic epoxide hydrolase and its functional expression in Escherichia coli. J Biol Chem 268: 17623-17627.
    • (1993) J Biol Chem , vol.268 , pp. 17623-17627
    • Knehr, M.1    Thomas, H.2    Arand, M.3    Gebel, T.4    Zeller, H.5    Oesch, F.6
  • 24
    • 0030806487 scopus 로고    scopus 로고
    • Repositioning the catalytic triad aspartic acid of haloalkane dehalogenase: Effects on stability, kinetics, and structure
    • Krooshof, G.H., Kwant, E.M., Damborsky, J., Koca, J. and Janssen, D.B. (1997) Repositioning the catalytic triad aspartic acid of haloalkane dehalogenase: effects on stability, kinetics, and structure. Biochemistry 36: 9571-9580.
    • (1997) Biochemistry , vol.36 , pp. 9571-9580
    • Krooshof, G.H.1    Kwant, E.M.2    Damborsky, J.3    Koca, J.4    Janssen, D.B.5
  • 25
    • 0000353408 scopus 로고
    • The catalytic mechanism of microsomal epoxide hydrolase involves an ester intermediate
    • Lacourciere, G.M. and Armstrong, R.N. (1993) The catalytic mechanism of microsomal epoxide hydrolase involves an ester intermediate. J Am Chem Soc 115: 10466-10467.
    • (1993) J Am Chem Soc , vol.115 , pp. 10466-10467
    • Lacourciere, G.M.1    Armstrong, R.N.2
  • 26
    • 0028354487 scopus 로고
    • Microsomal and soluble epoxide hydrolases are members of the same family of C-X bond hydrolase enzymes
    • Lacourciere, G.M. and Armstrong, R.N. (1994) Microsomal and soluble epoxide hydrolases are members of the same family of C-X bond hydrolase enzymes. Chem Res Toxicol 7: 121-124.
    • (1994) Chem Res Toxicol , vol.7 , pp. 121-124
    • Lacourciere, G.M.1    Armstrong, R.N.2
  • 27
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli, U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 28
    • 0029876665 scopus 로고    scopus 로고
    • Juvenile hormone metabolism in the ovary, gut, head, and carcass after blood feeding in the southern house mosquito, Culex quinquefasciatus
    • Lassiter, M.T., Apperson, C.S. and Roe, R.M. (1996) Juvenile hormone metabolism in the ovary, gut, head, and carcass after blood feeding in the southern house mosquito, Culex quinquefasciatus. Comp Biochem Physiol 113B: 229-237.
    • (1996) Comp Biochem Physiol , vol.113 B , pp. 229-237
    • Lassiter, M.T.1    Apperson, C.S.2    Roe, R.M.3
  • 30
    • 0022340498 scopus 로고
    • 4: Purification and characterization of a novel epoxide hydrolase from human erythrocytes
    • 4: purification and characterization of a novel epoxide hydrolase from human erythrocytes. J Biol Chem 260: 12832-12837.
    • (1985) J Biol Chem , vol.260 , pp. 12832-12837
    • McGee, J.1    Fitzpatrick, F.2
  • 31
  • 32
    • 0019293791 scopus 로고
    • Insect epoxide hydrolase: Properties of a purified enzyme from the southern armyworm (Spodoptera eridania)
    • Mullin, C.A. and Wilkinson, C.F. (1980) Insect epoxide hydrolase: properties of a purified enzyme from the southern armyworm (Spodoptera eridania). Pestic Biochem Physiol 14: 192-207.
    • (1980) Pestic Biochem Physiol , vol.14 , pp. 192-207
    • Mullin, C.A.1    Wilkinson, C.F.2
  • 33
    • 0003820974 scopus 로고
    • Princeton University Press, New York
    • Nijhout, H.F. (1994) Insect Hormones. Princeton University Press, New York.
    • (1994) Insect Hormones
    • Nijhout, H.F.1
  • 36
    • 0024411066 scopus 로고
    • Purification of hepoxilin epoxide hydrolase from rat liver
    • Pace-Asciak, C. and Lee, W. (1989) Purification of hepoxilin epoxide hydrolase from rat liver. J Biol Chem 264: 9310-9313.
    • (1989) J Biol Chem , vol.264 , pp. 9310-9313
    • Pace-Asciak, C.1    Lee, W.2
  • 37
    • 0028944334 scopus 로고
    • Molecular and biochemical evidence for the involvement of the Asp-333-His-523 pair in the catalytic mechanism of soluble epoxide hydrolase
    • Pinot, F., Grant, D.F., Beetham, J.K., Parker, A.G., Borhan, B., Landt, S., Jones, A.D. and Hammock, B.D. (1995) Molecular and biochemical evidence for the involvement of the Asp-333-His-523 pair in the catalytic mechanism of soluble epoxide hydrolase. J Biol Chem 270: 7968-7974.
    • (1995) J Biol Chem , vol.270 , pp. 7968-7974
    • Pinot, F.1    Grant, D.F.2    Beetham, J.K.3    Parker, A.G.4    Borhan, B.5    Landt, S.6    Jones, A.D.7    Hammock, B.D.8
  • 38
    • 0013429536 scopus 로고
    • Growth of larval Diatraea saccharalis (Lepidoptera: Pyralidae) on artificial diet and synchronization of the last larval stadium
    • Roe, R.M., Hammond, A.M., Jr and Sparks, T.C. (1982) Growth of larval Diatraea saccharalis (Lepidoptera: Pyralidae) on artificial diet and synchronization of the last larval stadium. Ann Entomol Soc Am 75, 421-429
    • (1982) Ann Entomol Soc Am , vol.75 , pp. 421-429
    • Roe, R.M.1    Hammond A.M., Jr.2    Sparks, T.C.3
  • 40
    • 0000507568 scopus 로고
    • Metabolism of juvenile hormones: Degradation and titer regulation
    • Rutgers University Press, New Brunswick
    • Roe, R.M. and Venkatesh, K. (1990) Metabolism of juvenile hormones: degradation and titer regulation. Morphogenetic Hormones of Arthropods, Volume I, pp. 126-179. Rutgers University Press, New Brunswick.
    • (1990) Morphogenetic Hormones of Arthropods , vol.1 , pp. 126-179
    • Roe, R.M.1    Venkatesh, K.2
  • 42
    • 0029800609 scopus 로고    scopus 로고
    • Kinetic characterization and X-ray structure of a mutant haloalkane dehalogenase with higher catalytic activity and modified substrate range
    • Schanstra, J.P., Ridder, I.S., Heimeriks, G.J., Rink, R., Poelarends, G.J., Kalk, K.H., Dijkstra, B.W. and Janssen, D.B. (1996) Kinetic characterization and X-ray structure of a mutant haloalkane dehalogenase with higher catalytic activity and modified substrate range. Biochemistry 35: 13186-13195.
    • (1996) Biochemistry , vol.35 , pp. 13186-13195
    • Schanstra, J.P.1    Ridder, I.S.2    Heimeriks, G.J.3    Rink, R.4    Poelarends, G.J.5    Kalk, K.H.6    Dijkstra, B.W.7    Janssen, D.B.8
  • 43
    • 0024286871 scopus 로고
    • A partition assay for the simultaneous determination of insect juvenile hormone esterase and epoxide hydrolase activity
    • Share, M.D. and Roe, R.M. (1988) A partition assay for the simultaneous determination of insect juvenile hormone esterase and epoxide hydrolase activity. Analyt Biochem 169: 81-88.
    • (1988) Analyt Biochem , vol.169 , pp. 81-88
    • Share, M.D.1    Roe, R.M.2
  • 44
    • 0023058975 scopus 로고
    • A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation
    • Shaw, G. and Kamen, R. (1986) A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell 46: 659-667.
    • (1986) Cell , vol.46 , pp. 659-667
    • Shaw, G.1    Kamen, R.2
  • 45
    • 0023835220 scopus 로고
    • Human microsomal xenobiotic epoxide hydrolase: Complementary DNA sequence, complementary DNA-directed expression in COS-1 cells, and chromosomal localization
    • Skoda, R.C., Demierre, A., McBride, O.W., Gonzalez, F.J. and Meyers, U.A. (1988) Human microsomal xenobiotic epoxide hydrolase: complementary DNA sequence, complementary DNA-directed expression in COS-1 cells, and chromosomal localization. J Biol Chem 263: 1549-1554.
    • (1988) J Biol Chem , vol.263 , pp. 1549-1554
    • Skoda, R.C.1    Demierre, A.2    McBride, O.W.3    Gonzalez, F.J.4    Meyers, U.A.5
  • 48
    • 0029911205 scopus 로고    scopus 로고
    • The catalytic mechanism of microsomal epoxide hydrolase involves reversible formation and rate-limiting hydrolysis of the alkylenzyme intermediate
    • Tzeng, H.-F., Laughlin, L.T., Lin, S. and Armstrong, R.N. (1996) The catalytic mechanism of microsomal epoxide hydrolase involves reversible formation and rate-limiting hydrolysis of the alkylenzyme intermediate. J Am Chem Soc 118: 9436-9437.
    • (1996) J Am Chem Soc , vol.118 , pp. 9436-9437
    • Tzeng, H.-F.1    Laughlin, L.T.2    Lin, S.3    Armstrong, R.N.4
  • 49
    • 0027337615 scopus 로고
    • Crystallographic analysis of the catalytic mechanism of haloalkane dehalogenase
    • Verschueren, K.H.G., Seljee, F., Rozeboom, H.J., Kalk, K.H. and Dijkstra, B.W. (1993) Crystallographic analysis of the catalytic mechanism of haloalkane dehalogenase. Nature 363: 693-698.
    • (1993) Nature , vol.363 , pp. 693-698
    • Verschueren, K.H.G.1    Seljee, F.2    Rozeboom, H.J.3    Kalk, K.H.4    Dijkstra, B.W.5
  • 50
    • 0025796711 scopus 로고
    • Codon usage tabulated from the GenBank genetic sequence data
    • Wada, K., Wada, Y., Doi, H., Ishibashi, F., Gojobori, T. and Ikemura, T. (1991) Codon usage tabulated from the GenBank genetic sequence data. Nucleic Acids Res 19, Supplement, 1981-1986.
    • (1991) Nucleic Acids Res , vol.19 , Issue.SUPPL. , pp. 1981-1986
    • Wada, K.1    Wada, Y.2    Doi, H.3    Ishibashi, F.4    Gojobori, T.5    Ikemura, T.6
  • 52
    • 0010482636 scopus 로고
    • Tissue specific juvenile hormone degradation in Galleria mellonella
    • Wisniewski, J.R., Rudnicka, M. and Kochman, M. (1986) Tissue specific juvenile hormone degradation in Galleria mellonella. Insect Biochem 16: 843-849.
    • (1986) Insect Biochem , vol.16 , pp. 843-849
    • Wisniewski, J.R.1    Rudnicka, M.2    Kochman, M.3
  • 54
    • 0029892255 scopus 로고    scopus 로고
    • An insect juvenile-hormone-specific epoxide hydrolase is related to vertebrate microsomal epoxide hydrolases
    • Wojtasek, H. and Prestwich, G.D. (1996) An insect juvenile-hormone-specific epoxide hydrolase is related to vertebrate microsomal epoxide hydrolases. Biochem Biophys Res Commun 220: 323-329.
    • (1996) Biochem Biophys Res Commun , vol.220 , pp. 323-329
    • Wojtasek, H.1    Prestwich, G.D.2
  • 55
    • 0018163020 scopus 로고
    • Metabolism of juvenile hormone I by microsomal oxidase, esterase, and epoxide hydrolase of Musca domestica and some comparisons with Phormia regina and Sarcophaga bullata
    • Yu, S.J. and Terriere, L.C. (1978) Metabolism of juvenile hormone I by microsomal oxidase, esterase, and epoxide hydrolase of Musca domestica and some comparisons with Phormia regina and Sarcophaga bullata. Pestic Biochem Physiol 9: 237-246.
    • (1978) Pestic Biochem Physiol , vol.9 , pp. 237-246
    • Yu, S.J.1    Terriere, L.C.2


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