Towards validation of glutathione S-transferase (GST) as a filarial nematode drug target

Chemico-Biological Interactions

Volumn 133, Issue 1-3, 2001, Pages 240-243

  Campbell, Alison M ^a   Van Eldik, Ria ^b   Liebau, Eva ^c   Barrett, John ^a   Brophy, Peter M ^a   Teesdale Spittle, Paul ^b   Wang, Meng F ^b  

^a ABERYSTWYTH UNIVERSITY   (United Kingdom)

^b DE MONTFORT UNIVERSITY   (United Kingdom)

^c BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE   (Germany)

Author keywords

Glutathione transferase; Inhibitor; Lipid peroxidation; Nematode

Indexed keywords

EID: 0039892577     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (4)

1. P.M. Brophy, D.I. Pritchard, Parasitic helminth glutathione S-transferases: an update on their potential as targets for immuno and chemotherapy, Exp. Parasitol. 79 (1994) 89-96.
2. E. Liebau, G. Wildenburg, P.M. Brophy, R.D. Walter, K. Henkle-Duhrsen, The 24 kDa gluthatione S-transferase from Onchocerca volvulus: biochemical analysis, localisation and gene structure, Mol. Biochem. Parasitol. 80 (1996) 27-39.
3. P.M. Brophy, A.M. Campbell, A.J. van Eldick, P.H. Teesdale-Spittle, E. Liebau, and M.F. Wang, β-carbonyl substituted glutathione conjugates as inhibitors of O. volvulus GST2, Bioorg. Med. Chem. Lett. (2000) in the press
4. R.M. Katuz, R.F. Colman, s-(4-bromo-2,3-dioxobutyl) glutathione - a new affinity label for the 4-4-isoenzyme of rat-liver glutathione-S-transferase, Biochemistry 30 (1991) 11230-11238.